Development and validation of a liquid chromatographic method for the simultaneous determination of four anthracyclines and their respective 13-S-dihydro metabolites in plasma and saliva

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 30, 2009, Pages 3907-3915

  Maudens, Kristof E ^a   Stove, Christophe P ^a   Cocquyt, Veronique F J ^b   Denys, Hannelore ^b   Lambert, Willy E ^a  

^a GHENT UNIVERSITY   (Belgium)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Anthracyclines; Daunorubicin; Daunorubicinol; Doxorubicin; Doxorubicinol; Epirubicin; Epirubicinol; Fluorescence detection; Idarubicin; Idarubicinol; Liquid chromatography; Liquid liquid extraction (LLE); Method validation; Plasma; Saliva

Indexed keywords

ANTHRACYCLINES; DAUNORUBICIN; DOXORUBICIN; DOXORUBICINOL; EPIRUBICIN; FLUORESCENCE DETECTION; IDARUBICIN; LIQUID-LIQUID EXTRACTION; METHOD VALIDATIONS;

ACETONITRILE; BIOASSAY; BIOMOLECULES; BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; DICHLOROMETHANE; ETHANOL; FLUORESCENCE; FORMIC ACID; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; METABOLISM; METABOLITES; ORGANIC ACIDS; PLASMAS; POLYMORPHISM; SOLVENT EXTRACTION; STABILITY CRITERIA;

LIQUIDS;

ALCOHOL; DAUNORUBICIN; DAUNORUBICIN DERIVATIVE; DAUNORUBICINOL; DOXORUBICIN; DOXORUBICINOL; EPIDAUNORUBICIN; EPIRUBICIN; EPIRUBICINOL; FORMIC ACID; IDARUBICIN; IDARUBICINOL; UNCLASSIFIED DRUG; WATER;

ACCURACY; ARTICLE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG SALIVA LEVEL; ELUTION; HUMAN; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; NEUTROPENIA; NORMAL HUMAN; PRECIPITATION; PRIORITY JOURNAL; QUANTITATIVE ASSAY; VALIDATION PROCESS;

ANTHRACYCLINES; CHROMATOGRAPHY, LIQUID; HUMANS; SALIVA;

EID: 72049089584     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.09.044     Document Type: Article

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