Traces of phosgene in chloroform: Consequences for extraction of anthracyclines

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 848, Issue 2, 2007, Pages 384-390

  Maudens, Kristof E ^a   Wille, Sarah M R ^a   Lambert, Willy E ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

2 Methyl 2 butene; Amylene; Anthracyclines; Chloroform; Ethanol; Liquid liquid extraction; Phosgene; Stability

Indexed keywords

2-METHYL-2-BUTENE; AMYLENE; ANTHRACYCLINES; LIQUID LIQUID EXTRACTION; PHOSGENE;

BIOLOGICAL MATERIALS; CHROMATOGRAPHIC ANALYSIS; DRUG PRODUCTS; ETHANOL; METABOLITES; VOLATILE ORGANIC COMPOUNDS;

CHLORINE COMPOUNDS;

13 S DIHYDRODOXORUBICIN; 13 S DIHYDROEPIRUBICIN; 2 METHYL 2 BUTENE; ALCOHOL; ALKENE; AMYLENE; ANTHRACYCLINE; CHLOROFORM; DAUNORUBICIN; DOXORUBICIN; DRUG METABOLITE; EPIRUBICIN; HYDROCARBON; IDARUBICIN; PHOSGENE; SOLVENT; STABILIZING AGENT; UNCLASSIFIED DRUG;

ARTICLE; ARTIFACT; CALIBRATION; CENTRIFUGATION; DRUG DETERMINATION; DRUG ISOLATION; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; REACTION ANALYSIS;

AMINES; ANTHRACYCLINES; CHLOROFORM; CHROMATOGRAPHY, LIQUID; DAUNORUBICIN; DOXORUBICIN; EPIRUBICIN; ETHANOL; IDARUBICIN; MOLECULAR STRUCTURE; PHOSGENE; REPRODUCIBILITY OF RESULTS; SOLVENTS; SPECTROMETRY, FLUORESCENCE;

EID: 33947427031     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2006.10.073     Document Type: Article

References (28)

1. Martindale. The Extra Pharmacopeia. 30th ed. (1993), The Pharmaceutical Press, London, United Kingdom p. 1401
2. Turk E. Chem. Eng. News 76 (1998) 6
3. Cone E.J., Buchwald W.F., and Darwin W.D. Drug Metab. Dispos. 10 (1982) 561
4. Middleditch B.S., and Zlatkis A. J. Chromatogr. Sci. 25 (1987) 547
5. Dolan J.W. LC-GC 4 (1986) 894
6. Dolan J.W. LC-GC 5 (1987) 874
7. Dolan J.W. LC-GC 6 (1988) 20
8. J.T. Baker, Technical Library Document 3035, Phillipsburg, NJ, 2000.
9. Middleditch B.S. Analytical Artifacts (1989), Elsevier, Amsterdam p. 591
10. Siek T.J., Eichmeier L.S., and Caplis M.E. J. Anal. Toxicol. 1 (1977) 211
11. Hansen S.H., and Nordholm L. J. Chromatogr. 204 (1981) 97
12. Wester R., Noonan P., Markos C., Bible R., Aksamit W., and Hribar J. J. Chromatogr. 209 (1981) 463
13. Grech-Bélanger O. J. Chromatogr. 309 (1984) 165
14. Holder C.L., Korfmacher W.A., Rushing L.G., Thompson H.C., Slikker W., and Gosnell A.B. J. Chromatogr. 419 (1987) 113
15. Moody J.D., Heinze T.M., and Cerniglia C.E. Biocatal. Biotransform. 19 (2001) 155
16. Menelaou A., Hutchinson M.R., Quinn I., Christensen A., and Somogyi A.A. J. Chromatogr. B 785 (2003) 81
17. Hortobagyi G.N. Drugs 54 Suppl. 4 (1997) 1
18. Mou C.M., Ganju N., Sridhar K.S., and Krishan A. J. Chromatogr. B 773 (1997) 217
19. Lachâtre F., Marquet P., Ragot S., Gaulier J.M., Cardot P., and Dupuy J.L. J. Chromatogr. B 738 (2000) 281
20. Mazuel C., Grove J., Gerin G., and Keenan K.P. J. Pharm. Biomed. Anal. 33 (2003) 1093
21. Beijnen J.H., Meenhorst P.L., Van Gijn R., Fromme M., Rosing H., and Underberg W.J.M. J. Pharm. Biomed. Anal. 9 (1991) 995
22. Marchiset-Leca D., and Leca F.R. Chromatographia 35 (1993) 435
23. Embree L., Gelmon K.A., Lohr A., Mayer L.D., Coldman A.J., Cullis P.R., Palaitis W., Pilkiewicz F., Hudon N.J., Heggie J.R., and Goldie J.H. J. Pharm. Sci. 82 (1993) 627
24. Fraier D., Frigerio E., Pianezzola E., Benedetti M.S., Cassidy J., and Vasey P. J. Pharm. Biomed. Anal. 13 (1995) 625
25. van Asperen J., van Tellingen O., and Beijnen J.H. J. Chromatogr. B 712 (1998) 129
26. Fogli S., Danesi R., Innocenti F., Di Paolo A., Bocci G., Barbara C., and Del Tacca M. Ther. Drug Monit. 21 (1999) 367
27. Dodde W.I.W., Maring J.G., Hendriks G., Wachters F.M., Groen H.J.M., de Vries E.G.E., and Uges D.R.A. Ther. Drug Monit. 25 (2003) 433
28. Qureshi M., Qureshi S.Z., Rathore H.S., and Mohammad A. J. Phys. Chem. 79 (1975) 116