메뉴 건너뛰기




Volumn 1309, Issue , 2010, Pages 136-145

Efficacy and safety profile of the carotenoid trans sodium crocetinate administered to rabbits following multiple infarct ischemic strokes: A combination therapy study with tissue plasminogen activator

Author keywords

Acute ischemic stroke; Behavior; Clinical; Embolism; Intracerebral hemorrhage; Neuroprotection; Toxicity; Translational science

Indexed keywords

CAROTENOID; SODIUM CHLORIDE; TISSUE PLASMINOGEN ACTIVATOR; TRANS SODIUM CROCETINATE; UNCLASSIFIED DRUG;

EID: 72049086023     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2009.10.067     Document Type: Article
Times cited : (23)

References (64)
  • 1
    • 0034087334 scopus 로고    scopus 로고
    • Effects of saffron extract and its constituent crocin on learning behaviour and long-term potentiation
    • Abe K., and Saito H. Effects of saffron extract and its constituent crocin on learning behaviour and long-term potentiation. Phytother. Res. 14 (2000) 149-152
    • (2000) Phytother. Res. , vol.14 , pp. 149-152
    • Abe, K.1    Saito, H.2
  • 2
    • 0034161354 scopus 로고    scopus 로고
    • Intravenous tissue-type plasminogen activator for treatment of acute stroke: the Standard Treatment with Alteplase to Reverse Stroke (STARS) study
    • Albers G.W., Bates V.E., Clark W.M., Bell R., Verro P., and Hamilton S.A. Intravenous tissue-type plasminogen activator for treatment of acute stroke: the Standard Treatment with Alteplase to Reverse Stroke (STARS) study. JAMA 283 (2000) 1145-1150
    • (2000) JAMA , vol.283 , pp. 1145-1150
    • Albers, G.W.1    Bates, V.E.2    Clark, W.M.3    Bell, R.4    Verro, P.5    Hamilton, S.A.6
  • 3
    • 0036259894 scopus 로고    scopus 로고
    • Stilbazulenyl nitrone, a novel azulenyl nitrone antioxidant: improved neurological deficit and reduced contusion size after traumatic brain injury in rats
    • Belayev L., Becker D.A., Alonso O.F., Liu Y., Busto R., Ley J.J., and Ginsberg M.D. Stilbazulenyl nitrone, a novel azulenyl nitrone antioxidant: improved neurological deficit and reduced contusion size after traumatic brain injury in rats. J. Neurosurg. 96 (2002) 1077-1083
    • (2002) J. Neurosurg. , vol.96 , pp. 1077-1083
    • Belayev, L.1    Becker, D.A.2    Alonso, O.F.3    Liu, Y.4    Busto, R.5    Ley, J.J.6    Ginsberg, M.D.7
  • 5
    • 0034120507 scopus 로고    scopus 로고
    • The rtPA (alteplase) 0- to 6-hour acute stroke trial, part A (A0276g): results of a double-blind, placebo-controlled, multicenter study. Thromblytic therapy in acute ischemic stroke study investigators
    • Clark W.M., Albers G.W., Madden K.P., and Hamilton S. The rtPA (alteplase) 0- to 6-hour acute stroke trial, part A (A0276g): results of a double-blind, placebo-controlled, multicenter study. Thromblytic therapy in acute ischemic stroke study investigators. Stroke 31 (2000) 811-816
    • (2000) Stroke , vol.31 , pp. 811-816
    • Clark, W.M.1    Albers, G.W.2    Madden, K.P.3    Hamilton, S.4
  • 6
    • 68749100878 scopus 로고    scopus 로고
    • Expansion of the time window for treatment of acute ischemic stroke with intravenous tissue plasminogen activator. A science advisory from the American Heart Association/American Stroke Association
    • Del Zoppo G.J., Saver J.L., Jauch E.C., and Adams Jr. H.P. Expansion of the time window for treatment of acute ischemic stroke with intravenous tissue plasminogen activator. A science advisory from the American Heart Association/American Stroke Association. Stroke 40 8 (2009) 2945-2948
    • (2009) Stroke , vol.40 , Issue.8 , pp. 2945-2948
    • Del Zoppo, G.J.1    Saver, J.L.2    Jauch, E.C.3    Adams Jr., H.P.4
  • 7
    • 0033199996 scopus 로고    scopus 로고
    • Pathobiology of ischaemic stroke: an integrated view
    • Dirnagl U., Iadecola C., and Moskowitz M.A. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci. 22 (1999) 391-397
    • (1999) Trends Neurosci. , vol.22 , pp. 391-397
    • Dirnagl, U.1    Iadecola, C.2    Moskowitz, M.A.3
  • 8
    • 33750632133 scopus 로고    scopus 로고
    • Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid
    • dos Santos M.D., Almeida M.C., Lopes N.P., and de Souza G.E. Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid. Biol. Pharm. Bull. 29 (2006) 2236-2240
    • (2006) Biol. Pharm. Bull. , vol.29 , pp. 2236-2240
    • dos Santos, M.D.1    Almeida, M.C.2    Lopes, N.P.3    de Souza, G.E.4
  • 9
    • 0037229213 scopus 로고    scopus 로고
    • Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters
    • EAISG
    • EAISG. Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters. Cerebrovasc. Dis. 15 (2003) 222-229
    • (2003) Cerebrovasc. Dis. , vol.15 , pp. 222-229
  • 10
    • 0032704101 scopus 로고    scopus 로고
    • Antioxidants, oxidative stress, and degenerative neurological disorders
    • Floyd R.A. Antioxidants, oxidative stress, and degenerative neurological disorders. Proc. Soc. Exp. Biol. Med. 222 (1999) 236-245
    • (1999) Proc. Soc. Exp. Biol. Med. , vol.222 , pp. 236-245
    • Floyd, R.A.1
  • 11
    • 45749128609 scopus 로고    scopus 로고
    • Trans-sodium crocetinate for treating hypoxia/ischemia
    • Gainer J.L. Trans-sodium crocetinate for treating hypoxia/ischemia. Expert Opin. Investig. Drugs 17 (2008) 917-924
    • (2008) Expert Opin. Investig. Drugs , vol.17 , pp. 917-924
    • Gainer, J.L.1
  • 12
    • 2942615338 scopus 로고    scopus 로고
    • Crocetin from saffron: an active component of an ancient spice
    • Giaccio M. Crocetin from saffron: an active component of an ancient spice. Crit. Rev. Food Sci. Nutr. 44 (2004) 155-172
    • (2004) Crit. Rev. Food Sci. Nutr. , vol.44 , pp. 155-172
    • Giaccio, M.1
  • 13
    • 0035212814 scopus 로고    scopus 로고
    • Trans-sodium crocetinate restores blood pressure, heart rate, and plasma lactate after hemorrhagic shock
    • Giassi L.J., Gilchrist M.J., Graham M.C., and Gainer J.L. Trans-sodium crocetinate restores blood pressure, heart rate, and plasma lactate after hemorrhagic shock. J. Trauma 51 (2001) 932-938
    • (2001) J. Trauma , vol.51 , pp. 932-938
    • Giassi, L.J.1    Gilchrist, M.J.2    Graham, M.C.3    Gainer, J.L.4
  • 14
    • 0040669773 scopus 로고    scopus 로고
    • Trans sodium crocetinate for hemorrhagic shock: effect of time delay in initiating therapy
    • Giassi L.J., Poynter A.K., and Gainer J.L. Trans sodium crocetinate for hemorrhagic shock: effect of time delay in initiating therapy. Shock 18 (2002) 585-588
    • (2002) Shock , vol.18 , pp. 585-588
    • Giassi, L.J.1    Poynter, A.K.2    Gainer, J.L.3
  • 15
    • 0028783948 scopus 로고
    • Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
    • NINDS rt-PA Trial
    • NINDS rt-PA Trial. Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N. Engl. J. Med. 333 (1995) 1581-1587
    • (1995) N. Engl. J. Med. , vol.333 , pp. 1581-1587
  • 16
    • 34250760916 scopus 로고    scopus 로고
    • Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger, for treatment of cardiovascular diseases
    • Higashi Y., Jitsuiki D., Chayama K., and Yoshizumi M. Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger, for treatment of cardiovascular diseases. Recent Patents Cardiovasc. Drug. Discov. 1 (2006) 85-93
    • (2006) Recent Patents Cardiovasc. Drug. Discov. , vol.1 , pp. 85-93
    • Higashi, Y.1    Jitsuiki, D.2    Chayama, K.3    Yoshizumi, M.4
  • 17
    • 4544368193 scopus 로고    scopus 로고
    • Stroke-incidence, mortality, morbidity and risk
    • Ingall T. Stroke-incidence, mortality, morbidity and risk. J. Insur. Med. 36 (2004) 143-152
    • (2004) J. Insur. Med. , vol.36 , pp. 143-152
    • Ingall, T.1
  • 18
    • 33645684629 scopus 로고    scopus 로고
    • Edaravone in acute ischemic stroke
    • Kitagawa Y. Edaravone in acute ischemic stroke. Intern. Med. 45 (2006) 225-226
    • (2006) Intern. Med. , vol.45 , pp. 225-226
    • Kitagawa, Y.1
  • 20
    • 66849089771 scopus 로고    scopus 로고
    • Treatment time-specific number needed to treat estimates for tissue plasminogen activator therapy in acute stroke based on shifts over the entire range of the modified Rankin Scale
    • Lansberg M.G., Schrooten M., Bluhmki E., Thijs V.N., and Saver J.L. Treatment time-specific number needed to treat estimates for tissue plasminogen activator therapy in acute stroke based on shifts over the entire range of the modified Rankin Scale. Stroke 40 (2009) 2079-2084
    • (2009) Stroke , vol.40 , pp. 2079-2084
    • Lansberg, M.G.1    Schrooten, M.2    Bluhmki, E.3    Thijs, V.N.4    Saver, J.L.5
  • 21
    • 0036850280 scopus 로고    scopus 로고
    • Development of thrombolytic therapy for stroke: a perspective. Expert Opin
    • Lapchak P.A. Development of thrombolytic therapy for stroke: a perspective. Expert Opin. Investig. Drugs 11 (2002) 1623-1632
    • (2002) Investig. Drugs , vol.11 , pp. 1623-1632
    • Lapchak, P.A.1
  • 22
    • 0036370325 scopus 로고    scopus 로고
    • Hemorrhagic transformation following ischemic stroke: significance, causes, and relationship to therapy and treatment
    • Lapchak P.A. Hemorrhagic transformation following ischemic stroke: significance, causes, and relationship to therapy and treatment. Curr. Neurol. Neurosci. Rep. 2 (2002) 38-43
    • (2002) Curr. Neurol. Neurosci. Rep. , vol.2 , pp. 38-43
    • Lapchak, P.A.1
  • 23
    • 30444457573 scopus 로고    scopus 로고
    • 3alpha-OL-5-beta-pregnan-20-one hemisuccinate, a steroidal low-affinity NMDA receptor antagonist improves clinical rating scores in a rabbit multiple infarct ischemia model: synergism with tissue plasminogen activator
    • Lapchak P.A. 3alpha-OL-5-beta-pregnan-20-one hemisuccinate, a steroidal low-affinity NMDA receptor antagonist improves clinical rating scores in a rabbit multiple infarct ischemia model: synergism with tissue plasminogen activator. Exp. Neurol. 197 (2006) 531-537
    • (2006) Exp. Neurol. , vol.197 , pp. 531-537
    • Lapchak, P.A.1
  • 24
    • 34248664073 scopus 로고    scopus 로고
    • The phenylpropanoid micronutrient chlorogenic acid improves clinical rating scores in rabbits following multiple infarct ischemic strokes: synergism with tissue plasminogen activator
    • Lapchak P.A. The phenylpropanoid micronutrient chlorogenic acid improves clinical rating scores in rabbits following multiple infarct ischemic strokes: synergism with tissue plasminogen activator. Exp. Neurol. 205 (2007) 407-413
    • (2007) Exp. Neurol. , vol.205 , pp. 407-413
    • Lapchak, P.A.1
  • 25
    • 70249144995 scopus 로고    scopus 로고
    • Effect of internal carotid artery reperfusion in combination with Tenecteplase on clinical scores and hemorrhage in a rabbit embolic stroke model
    • Lapchak P.A. Effect of internal carotid artery reperfusion in combination with Tenecteplase on clinical scores and hemorrhage in a rabbit embolic stroke model. Brain Res. 1294 (2009) 211-217
    • (2009) Brain Res. , vol.1294 , pp. 211-217
    • Lapchak, P.A.1
  • 26
    • 0042122368 scopus 로고    scopus 로고
    • Ebselen, a seleno-organic antioxidant, is neuroprotective after emoblic strokes in rabbits-synergism with low dose tissue plasminogen activator
    • Lapchak P.A., and Zivin J.A. Ebselen, a seleno-organic antioxidant, is neuroprotective after emoblic strokes in rabbits-synergism with low dose tissue plasminogen activator. Stroke 34 (2003) 2013-2018
    • (2003) Stroke , vol.34 , pp. 2013-2018
    • Lapchak, P.A.1    Zivin, J.A.2
  • 27
    • 33947652677 scopus 로고    scopus 로고
    • Advances in ischemic stroke treatment: neuroprotective and combination therapies
    • Lapchak P.A., and Araujo D.M. Advances in ischemic stroke treatment: neuroprotective and combination therapies. Expert Opin. Emerg. Drugs 12 (2007) 97-112
    • (2007) Expert Opin. Emerg. Drugs , vol.12 , pp. 97-112
    • Lapchak, P.A.1    Araujo, D.M.2
  • 28
    • 34548115488 scopus 로고    scopus 로고
    • Advances in hemorrhagic stroke therapy: conventional and novel approaches
    • Lapchak P.A., and Araujo D.M. Advances in hemorrhagic stroke therapy: conventional and novel approaches. Expert Opin. Emerg. Drugs 12 (2007) 389-406
    • (2007) Expert Opin. Emerg. Drugs , vol.12 , pp. 389-406
    • Lapchak, P.A.1    Araujo, D.M.2
  • 29
    • 72049117774 scopus 로고    scopus 로고
    • The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor simvastatin reduces thrombolytic-induced intracerebral hemorrhage in embolized rabbits
    • Lapchak P.A., and Han M.K. The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor simvastatin reduces thrombolytic-induced intracerebral hemorrhage in embolized rabbits. Brain Res. 1303 (2009) 144-150
    • (2009) Brain Res. , vol.1303 , pp. 144-150
    • Lapchak, P.A.1    Han, M.K.2
  • 30
    • 57449103131 scopus 로고    scopus 로고
    • The lipophilic multifunctional antioxidant edaravone (radicut) improves behavior following embolic strokes in rabbits: a combination therapy study with tissue plasminogen activator
    • Lapchak P.A., and Zivin J.A. The lipophilic multifunctional antioxidant edaravone (radicut) improves behavior following embolic strokes in rabbits: a combination therapy study with tissue plasminogen activator. Exp. Neurol. 215 (2009) 95-100
    • (2009) Exp. Neurol. , vol.215 , pp. 95-100
    • Lapchak, P.A.1    Zivin, J.A.2
  • 31
    • 0036098259 scopus 로고    scopus 로고
    • Neuroprotective effects of the spin trap agent disodium-[(tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (generic NXY-059) in a rabbit small clot embolic stroke model: combination studies with the thrombolytic tissue plasminogen activator
    • Lapchak P.A., Araujo D.M., Song D., Wei J., and Zivin J.A. Neuroprotective effects of the spin trap agent disodium-[(tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (generic NXY-059) in a rabbit small clot embolic stroke model: combination studies with the thrombolytic tissue plasminogen activator. Stroke 33 (2002) 1411-1415
    • (2002) Stroke , vol.33 , pp. 1411-1415
    • Lapchak, P.A.1    Araujo, D.M.2    Song, D.3    Wei, J.4    Zivin, J.A.5
  • 32
    • 0347624526 scopus 로고    scopus 로고
    • Comparison of Tenecteplase with Alteplase on clinical rating scores following small clot embolic strokes in rabbits
    • Lapchak P.A., Araujo D.M., and Zivin J.A. Comparison of Tenecteplase with Alteplase on clinical rating scores following small clot embolic strokes in rabbits. Exp. Neurol. 185 (2004) 154-159
    • (2004) Exp. Neurol. , vol.185 , pp. 154-159
    • Lapchak, P.A.1    Araujo, D.M.2    Zivin, J.A.3
  • 33
    • 3042706259 scopus 로고    scopus 로고
    • Coadministration of NXY-059 and tenecteplase six hours following embolic strokes in rabbits improves clinical rating scores
    • Lapchak P.A., Song D., Wei J., and Zivin J.A. Coadministration of NXY-059 and tenecteplase six hours following embolic strokes in rabbits improves clinical rating scores. Exp. Neurol. 188 (2004) 279-285
    • (2004) Exp. Neurol. , vol.188 , pp. 279-285
    • Lapchak, P.A.1    Song, D.2    Wei, J.3    Zivin, J.A.4
  • 34
    • 3042828639 scopus 로고    scopus 로고
    • Pharmacology of caffeinol in embolized rabbits: clinical rating scores and intracerebral hemorrhage incidence
    • Lapchak P.A., Song D., Wei J., and Zivin J.A. Pharmacology of caffeinol in embolized rabbits: clinical rating scores and intracerebral hemorrhage incidence. Exp. Neurol. 188 (2004) 286-291
    • (2004) Exp. Neurol. , vol.188 , pp. 286-291
    • Lapchak, P.A.1    Song, D.2    Wei, J.3    Zivin, J.A.4
  • 35
    • 3242764671 scopus 로고    scopus 로고
    • Transcranial infrared laser therapy improves clinical rating scores after embolic strokes in rabbits
    • Lapchak P.A., Wei J., and Zivin J.A. Transcranial infrared laser therapy improves clinical rating scores after embolic strokes in rabbits. Stroke 35 (2004) 1985-1988
    • (2004) Stroke , vol.35 , pp. 1985-1988
    • Lapchak, P.A.1    Wei, J.2    Zivin, J.A.3
  • 36
    • 36749068009 scopus 로고    scopus 로고
    • Baicalein, an antioxidant 12/15-lipoxygenase inhibitor improves clinical rating scores following multiple infarct embolic strokes
    • Lapchak P.A., Maher P., Schubert D., and Zivin J.A. Baicalein, an antioxidant 12/15-lipoxygenase inhibitor improves clinical rating scores following multiple infarct embolic strokes. Neuroscience 150 (2007) 585-591
    • (2007) Neuroscience , vol.150 , pp. 585-591
    • Lapchak, P.A.1    Maher, P.2    Schubert, D.3    Zivin, J.A.4
  • 37
    • 34548808028 scopus 로고    scopus 로고
    • Transcranial near-infrared light therapy improves motor function following embolic strokes in rabbits: an extended therapeutic window study using continuous and pulse frequency delivery modes
    • Lapchak P.A., Salgado K.F., Chao C.H., and Zivin J.A. Transcranial near-infrared light therapy improves motor function following embolic strokes in rabbits: an extended therapeutic window study using continuous and pulse frequency delivery modes. Neuroscience 148 (2007) 907-914
    • (2007) Neuroscience , vol.148 , pp. 907-914
    • Lapchak, P.A.1    Salgado, K.F.2    Chao, C.H.3    Zivin, J.A.4
  • 38
    • 55749094157 scopus 로고    scopus 로고
    • Safety profile of transcranial near-infrared laser therapy administered in combination with thrombolytic therapy to embolized rabbits
    • Lapchak P.A., Han M.K., Salgado K.F., Streeter J., and Zivin J.A. Safety profile of transcranial near-infrared laser therapy administered in combination with thrombolytic therapy to embolized rabbits. Stroke 39 (2008) 3073-3078
    • (2008) Stroke , vol.39 , pp. 3073-3078
    • Lapchak, P.A.1    Han, M.K.2    Salgado, K.F.3    Streeter, J.4    Zivin, J.A.5
  • 39
    • 0027562635 scopus 로고
    • Hemorrhagic transformation after cerebral ischemia: mechanisms and incidence
    • Lyden P.D., and Zivin J.A. Hemorrhagic transformation after cerebral ischemia: mechanisms and incidence. Cerebrovasc. Brain Metab. Rev. 5 (1993) 1-16
    • (1993) Cerebrovasc. Brain Metab. Rev. , vol.5 , pp. 1-16
    • Lyden, P.D.1    Zivin, J.A.2
  • 40
    • 0023395552 scopus 로고
    • Intracerebral hemorrhage after experimental embolic infarction. Anticoagulation
    • Lyden P.D., Zivin J.A., Soll M., Sitzer M., Rothrock J.F., and Alksne J. Intracerebral hemorrhage after experimental embolic infarction. Anticoagulation. Arch. Neurol. 44 (1987) 848-850
    • (1987) Arch. Neurol. , vol.44 , pp. 848-850
    • Lyden, P.D.1    Zivin, J.A.2    Soll, M.3    Sitzer, M.4    Rothrock, J.F.5    Alksne, J.6
  • 41
    • 0025609948 scopus 로고
    • Incidence of cerebral hemorrhage after treatment with tissue plasminogen activator or streptokinase following embolic stroke in rabbits [corrected]
    • Lyden P.D., Madden K.P., Clark W.M., Sasse K.C., and Zivin J.A. Incidence of cerebral hemorrhage after treatment with tissue plasminogen activator or streptokinase following embolic stroke in rabbits [corrected]. Stroke 21 (1990) 1589-1593
    • (1990) Stroke , vol.21 , pp. 1589-1593
    • Lyden, P.D.1    Madden, K.P.2    Clark, W.M.3    Sasse, K.C.4    Zivin, J.A.5
  • 42
    • 0034130765 scopus 로고    scopus 로고
    • Synergistic combinatorial stroke therapy: a quantal bioassay of a GABA agonist and a glutamate antagonist
    • Lyden P.D., Jackson-Friedman C., Shin C., and Hassid S. Synergistic combinatorial stroke therapy: a quantal bioassay of a GABA agonist and a glutamate antagonist. Exp. Neurol. 163 (2000) 477-489
    • (2000) Exp. Neurol. , vol.163 , pp. 477-489
    • Lyden, P.D.1    Jackson-Friedman, C.2    Shin, C.3    Hassid, S.4
  • 43
    • 34548855340 scopus 로고    scopus 로고
    • A novel approach to screening for new neuroprotective compounds for the treatment of stroke
    • Maher P., Salgado K.F., Zivin J.A., and Lapchak P.A. A novel approach to screening for new neuroprotective compounds for the treatment of stroke. Brain Res. 1173 (2007) 117-125
    • (2007) Brain Res. , vol.1173 , pp. 117-125
    • Maher, P.1    Salgado, K.F.2    Zivin, J.A.3    Lapchak, P.A.4
  • 44
    • 72049115923 scopus 로고    scopus 로고
    • Trans-sodium crocetinate (TSC) limits ischemic brain injury
    • Manabe H., Y. R., and Okonkwo D.O. Trans-sodium crocetinate (TSC) limits ischemic brain injury. Soc. Neurosci. (2007)
    • (2007) Soc. Neurosci.
    • Manabe, H.1    Y., R.2    Okonkwo, D.O.3
  • 45
    • 25144482448 scopus 로고    scopus 로고
    • Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes
    • Masella R., Di Benedetto R., Vari R., Filesi C., and Giovannini C. Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes. J. Nutr. Biochem. 16 (2005) 577-586
    • (2005) J. Nutr. Biochem. , vol.16 , pp. 577-586
    • Masella, R.1    Di Benedetto, R.2    Vari, R.3    Filesi, C.4    Giovannini, C.5
  • 47
    • 0242475057 scopus 로고    scopus 로고
    • Trans-sodium crocetinate increases oxygen delivery to brain parenchyma in rats on oxygen supplementation
    • Okonkwo D.O., Wagner J., Melon D.E., Alden T., Stone J.R., Helm G.A., and Jane Sr. J.A. Trans-sodium crocetinate increases oxygen delivery to brain parenchyma in rats on oxygen supplementation. Neurosci. Lett. 352 (2003) 97-100
    • (2003) Neurosci. Lett. , vol.352 , pp. 97-100
    • Okonkwo, D.O.1    Wagner, J.2    Melon, D.E.3    Alden, T.4    Stone, J.R.5    Helm, G.A.6    Jane Sr., J.A.7
  • 48
    • 0032164061 scopus 로고    scopus 로고
    • A novel fluid resuscitation therapy for hemorrhagic shock
    • Roy J.W., Graham M.C., Griffin A.M., and Gainer J.L. A novel fluid resuscitation therapy for hemorrhagic shock. Shock 10 (1998) 213-217
    • (1998) Shock , vol.10 , pp. 213-217
    • Roy, J.W.1    Graham, M.C.2    Griffin, A.M.3    Gainer, J.L.4
  • 49
    • 67650084702 scopus 로고    scopus 로고
    • Number needed to treat to benefit and to harm for intravenous tissue plasminogen activator therapy in the 3- to 4.5-hour window. Joint Outcome Table Analysis of the ECASS 3 Trial
    • Saver J.L., Gornbein J., Grotta J., Liebeskind D., Lutsep H., Schwamm L., Scott P., and Starkman S. Number needed to treat to benefit and to harm for intravenous tissue plasminogen activator therapy in the 3- to 4.5-hour window. Joint Outcome Table Analysis of the ECASS 3 Trial. Stroke 40 7 (2009) 2433-2437
    • (2009) Stroke , vol.40 , Issue.7 , pp. 2433-2437
    • Saver, J.L.1    Gornbein, J.2    Grotta, J.3    Liebeskind, D.4    Lutsep, H.5    Schwamm, L.6    Scott, P.7    Starkman, S.8
  • 52
    • 9644266851 scopus 로고    scopus 로고
    • TSC for hemorrhagic shock: effects on cytokines and blood pressure
    • Stennett A.K., and Gainer J.L. TSC for hemorrhagic shock: effects on cytokines and blood pressure. Shock 22 (2004) 569-574
    • (2004) Shock , vol.22 , pp. 569-574
    • Stennett, A.K.1    Gainer, J.L.2
  • 53
    • 33749607010 scopus 로고    scopus 로고
    • trans-Sodium crocetinate and diffusion enhancement
    • Stennett A.K., Dempsey G.L., and Gainer J.L. trans-Sodium crocetinate and diffusion enhancement. J. Phys. Chem., B 110 (2006) 18078-18080
    • (2006) J. Phys. Chem., B , vol.110 , pp. 18078-18080
    • Stennett, A.K.1    Dempsey, G.L.2    Gainer, J.L.3
  • 54
    • 34548035459 scopus 로고    scopus 로고
    • Trans-sodium crocetinate and hemorrhagic shock
    • Stennett A.K., Murray R.J., Roy J.W., and Gainer J.L. Trans-sodium crocetinate and hemorrhagic shock. Shock 28 (2007) 339-344
    • (2007) Shock , vol.28 , pp. 339-344
    • Stennett, A.K.1    Murray, R.J.2    Roy, J.W.3    Gainer, J.L.4
  • 55
    • 45749148374 scopus 로고    scopus 로고
    • The effects of resuscitation with trans-sodium crocetinate in a model of hemorrhagic shock and traumatic brain injury
    • Stern S.A., Z. B., and Want X. The effects of resuscitation with trans-sodium crocetinate in a model of hemorrhagic shock and traumatic brain injury. Acad. Emerg. Med. 9 (2002) 415-416
    • (2002) Acad. Emerg. Med. , vol.9 , pp. 415-416
    • Stern, S.A.1    Z., B.2    Want, X.3
  • 56
    • 34249746809 scopus 로고    scopus 로고
    • Effect of edaravone, a free radical scavenger, on ischemic cerebral edema assessed by magnetic resonance imaging
    • discussion 201-2
    • Suda S., Igarashi H., Arai Y., Andou J., Chishiki T., and Katayama Y. Effect of edaravone, a free radical scavenger, on ischemic cerebral edema assessed by magnetic resonance imaging. Neurol. Med. Chir. (Tokyo) 47 (2007) 197-201 discussion 201-2
    • (2007) Neurol. Med. Chir. (Tokyo) , vol.47 , pp. 197-201
    • Suda, S.1    Igarashi, H.2    Arai, Y.3    Andou, J.4    Chishiki, T.5    Katayama, Y.6
  • 57
    • 0036019074 scopus 로고    scopus 로고
    • Treatment of acute ischemic stroke: recent progress
    • Tanahashi N., and Fukuuchi Y. Treatment of acute ischemic stroke: recent progress. Intern. Med. 41 (2002) 337-344
    • (2002) Intern. Med. , vol.41 , pp. 337-344
    • Tanahashi, N.1    Fukuuchi, Y.2
  • 58
    • 46849106962 scopus 로고    scopus 로고
    • The novel antioxidant edaravone: from bench to bedside
    • Watanabe T., Tahara M., and Todo S. The novel antioxidant edaravone: from bench to bedside. Cardiovasc. Ther. 26 (2008) 101-114
    • (2008) Cardiovasc. Ther. , vol.26 , pp. 101-114
    • Watanabe, T.1    Tahara, M.2    Todo, S.3
  • 59
    • 0015462036 scopus 로고
    • On biological assays involving quantal responses
    • Waud D.R. On biological assays involving quantal responses. J. Pharmacol. Exp. Theory 183 (1972) 577-607
    • (1972) J. Pharmacol. Exp. Theory , vol.183 , pp. 577-607
    • Waud, D.R.1
  • 60
    • 9344249608 scopus 로고    scopus 로고
    • Vascular and anti-oxidant actions of flavonols and flavones
    • Woodman O.L., and Chan E. Vascular and anti-oxidant actions of flavonols and flavones. Clin. Exp. Pharmacol. Physiol. 31 (2004) 786-790
    • (2004) Clin. Exp. Pharmacol. Physiol. , vol.31 , pp. 786-790
    • Woodman, O.L.1    Chan, E.2
  • 61
    • 0031963836 scopus 로고    scopus 로고
    • Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Ebselen Study Group
    • Yamaguchi T., Sano K., Takakura K., Saito I., Shinohara Y., Asano T., and Yasuhara H. Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Ebselen Study Group. Stroke 29 (1998) 12-17
    • (1998) Stroke , vol.29 , pp. 12-17
    • Yamaguchi, T.1    Sano, K.2    Takakura, K.3    Saito, I.4    Shinohara, Y.5    Asano, T.6    Yasuhara, H.7
  • 62
  • 63
    • 0026696401 scopus 로고
    • Quantal bioassay and stroke
    • Zivin J.A., and Waud D.R. Quantal bioassay and stroke. Stroke 23 (1992) 767-773
    • (1992) Stroke , vol.23 , pp. 767-773
    • Zivin, J.A.1    Waud, D.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.