Structural identification of three metabolites and a degradation product of the macrolide immunosuppressant sirolimus (rapamycin) by electrospray-MS/MS after incubation with human liver microsomes

Drug Metabolism and Disposition

Volumn 24, Issue 11, 1996, Pages 1272-1278

  Streit, Frank ^b   Christians, Uwe ^a   Schiebel, Hans Martin ^c   Meyer, Anke ^d   Sewing, Karl Friedrich ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^d HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; MACROLIDE; RAPAMYCIN;

ARTICLE; CONTROLLED STUDY; DISSOCIATION; DRUG DEGRADATION; DRUG HYDROXYLATION; DRUG STRUCTURE; HUMAN; HUMAN CELL; LIVER MICROSOME METABOLISM; MASS SPECTROMETRY; PRIORITY JOURNAL;

HUMANS; HYDROLYSIS; IMMUNOSUPPRESSIVE AGENTS; MASS SPECTROMETRY; MICROSOMES, LIVER; MOLECULAR STRUCTURE; POLYENES; SIROLIMUS;

STAPHYLOCOCCUS PHAGE 3A;

EID: 0030476603     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

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