Edaravone, a free radical scavenger, in the treatment of idiopathic sudden sensorineural hearing loss with profound hearing loss

Auris Nasus Larynx

Volumn 37, Issue 1, 2010, Pages 42-46

  Sano, Hajime ^a   Kamijo, Takahiro ^a   Ino, Takeshi ^a   Okamoto, Makito ^a  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Free radical scavenger; HBO; ISSHL; Profound hearing loss

Indexed keywords

ADENOSINE TRIPHOSPHATE; BETAMETHASONE; NORPHENAZONE; PROSTAVASIN; UBIDECARENONE; VITAMIN B GROUP;

ACUTE KIDNEY FAILURE; ADULT; AGED; ARTICLE; AUDITORY THRESHOLD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG DOSE COMPARISON; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG ERUPTION; HEARING ACUITY; HEARING LOSS; HUMAN; HYPERBARIC OXYGEN; LIVER DYSFUNCTION; OUTCOME ASSESSMENT; PERCEPTION DEAFNESS; PROGNOSIS; PURE TONE AUDIOMETRY; THROMBOCYTOPENIA;

ADULT; AGED; ANTIPYRINE; AUDIOMETRY, PURE-TONE; FEMALE; FREE RADICAL SCAVENGERS; HEARING LOSS, SENSORINEURAL; HUMANS; HYPERBARIC OXYGENATION; MALE; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 71849117435     PISSN: 03858146     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.anl.2009.04.012     Document Type: Article

References (17)

1. Wilson W.R., and Byl F.M. The efficacy of steroid in the treatment of idiopathic sudden hearing loss. Arch Otolaryngol 106 (1980) 772-776
2. Kronenberg J., Almagor M., Bendet E., and Kushnir D. Vasoactive therapy versus placebo in the treatment of sudden hearing loss: a double blind clinical study. Laryngoscope 102 (1992) 65-68
3. Uri N., Doweck I., Cohen-Kerem R., and Greenberg E. Acyclovir in the treatment of idiopathic sudden sensorineural hearing loss. Otolaryngol Head Neck Surg 128 (2003) 544-549
4. Westerlaken B.O., Stokroos R.J., Dhooge I.J.M., Wit H.P., and Albers F.W. Treatment of idiopathic sudden sensorineural hearing loss with antiviral therapy: a prospective, randomized, double-blind clinical trial. Ann Otol Laryngol 112 (2003) 993-1000
5. Ahn J.H., Yoo M.H., Yoon T.H., and Chung J.W. Can intratympanic dexamethasone added to systemic steroids improve gearing outcome in patients with sudden deafness?. Laryngoscope. 118 (2008) 279-282
6. Westerlaken B.O., Kleine E., van der Laan B., and Albers F. The treatment of idiopathic sudden sensorineural hearing loss using pulse therapy: a prospective, randomized, double-blind clinical trial. Laryngoscope 117 (2007) 684-690
7. Klemm E., Bepperling F., Burschka M.A., Mosges R., and Study Group. Hemodilution therapy with hydrosyethyl starch solution in unilateral idiopathic sudden sensorineural hearing loss: a dose finding, placebo-controlled, international multicenter trial with 210 patients. Otol Neurotol 28 (2007) 157-170
8. Mattox D.E., and Simmons F.B. Natural history of sudden sensorineural hearing loss. Ann Otol Rhinol Larngol 86 (1977) 463-480
9. Byl F.M. Sudden hearing loss eight years' experience and suggested prognostic table. Laryngoscope 94 (1984) 647-661
10. Nakashima T., and Yanagita N. Outcome of sudden deafness with and without vertigo. Laryngoscope 103 (1993) 1145-1149
11. Sano H., Okamoto M., Shitara T., and Hirayama M. What kind of patients are suitable for evaluating the therapeutic effect of sudden deafness?. Am J Otol 19 (1998) 579-583
12. Nitta M., Okamoto M., Sano H., and Ono Y. Classification of idiopathic sudden sensorineural hearing loss base on prognosis. Otol Jpn 12 (2002) 15-20
13. The Edaravone Acute Infarction Study Group. Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters. Cerebrovasc Dis 15 (2003) 222-229
14. Abe S., Kirima K., Tsuchiya K., Okamoto M., and Hasegawa T. The reaction rate of edaravone with hydroxyl radical. Chem Pharm Bull (Tokyo) 52 (2004) 186-191
15. Maetani T., Hakuba N., Taniguchi M., Hyodo J., Shimizu Y., and Gyo K. Free radical scavenger protects against inner hair cell loss after cochlea ischemia. NeuroReport 14 (2003) 1881-1884
16. Takamatsu Y., and Watanabe T. Studies on the concentration of 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186) in dog plasma and cerebral spiral fluid. Jpn Pharmacol Ther (1997) 1793-1797 25 Supplement's
17. Hahimoto D., Sano H., Kamijo T., and Okamoto M. A clinical study of hyperbaric oxygenation therapy for idiopathic sudden sensorineural deafness. Audiol Jpn 49 (2006) 74-81