Can intratympanic dexamethasone added to systemic steroids improve hearing outcome in patients with sudden deafness?

Laryngoscope

Volumn 118, Issue 2, 2008, Pages 279-282

  Ahn, Joong Ho ^a   Yoo, Myung Hoon ^a   Yoon, Tae Hyun ^a   Chung, Jong Woo ^a  

^a University of Ulsan College of Medicine   (South Korea)

Author keywords

Dexamethasone; Injection; Sudden sensorineural hearing loss; Tympanum

Indexed keywords

DEXAMETHASONE; METHYLPREDNISOLONE; STEROID; ANTIINFLAMMATORY AGENT;

ADD ON THERAPY; ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; HEARING ACUITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; PERCEPTION DEAFNESS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SUDDEN DEAFNESS; TREATMENT OUTCOME; CONVALESCENCE; DRUG ADMINISTRATION; EARDRUM; INJECTION; MIDDLE AGED; PREVALENCE; PROSPECTIVE STUDY; PURE TONE AUDIOMETRY;

ANTI-INFLAMMATORY AGENTS; AUDIOMETRY, PURE-TONE; DEXAMETHASONE; DRUG ADMINISTRATION SCHEDULE; FEMALE; HEARING LOSS, SENSORINEURAL; HEARING LOSS, SUDDEN; HUMANS; INJECTIONS; MALE; MIDDLE AGED; PREVALENCE; PROSPECTIVE STUDIES; RECOVERY OF FUNCTION; TYMPANIC MEMBRANE;

EID: 40949110638     PISSN: 0023852X     EISSN: None     Source Type: Journal    
DOI: 10.1097/MLG.0b013e3181585428     Document Type: Article

References (19)

1. Whitaker S. Idiopathic sudden hearing loss. Am J Otol 1980;1:180-183.
2. Wilson WR, Byl FM, Laird N. The efficacy of steroids in the treatment of idiopathic sudden hearing loss. A double-blind clinical study. Arch Otolaryngol 1980;106:772-776.
3. Parnes LS, Sun AH, Freeman DJ. Corticosteroid pharmacokinetics in the inner ear fluids: an animal study followed by clinical application. Laryngoscope 1999;109:1-17.
4. Chandrasekhar SS. Intratympanic dexamethasone for sudden sensorineural hearing loss: clinical and laboratory evaluation. Otol Neurotol 2001;22:18-23.
5. Herr BD, Marzo SJ. Intratympanic steroid perfusion for refractory sudden sensorineural hearing loss. Otolaryngol Head Neck Surg 2005;132:527-531.
6. Choung YH, Park K, Shin YR, Cho MJ. Intratympanic dexamethasone injection for refractory sudden sensorineural hearing loss. Laryngoscope 2006;116:747-752.
7. Kilic R, Safak MA, Oguz H, et al. Intratympanic methylprednisolone for sudden sensorineural hearing loss. Otol Neurotol 2007;28:312-316.
8. Fitzgerald DC, McGuire JF. Intratympanic steroids for idiopathic sudden sensorineural hearing loss. Ann Otol Rhinol Laryngol 2007;116:253-256.
9. Siegel LG. The treatment of idiopathic sudden sensorineural hearing loss. Otolaryngol Clin North Am 1975;8:467-473.
10. Rarey KE, Curtis LM. Receptors for glucocorticoids in the human inner ear. Otolaryngol Head Neck Surg 1996;115:38-41.
11. Erichsen S, Stierna P, Bagger-Sjoback D, et al. Distribution of Na,K-ATPase is normal in the inner ear of a mouse with a null mutation of the glucocorticoid receptor. Hear Res 1998;124:146-154.
12. Himeno C, Komeda M, Izumikawa M, et al. Intra-cochlear administration of dexamethasone attenuates aminoglycoside ototoxicity in the guinea pig. Hear Res 2002;167:61-70.
13. Kopke RD, Hoffer ME, Wester D, O'Leary MJ, Jackson RL. Targeted topical steroid therapy in sudden sensorineural hearing loss. Otol Neurotol 2001;22:475-479.
14. Balyan FR, Taibah A, De DG, et al. Titration streptomycin therapy in Menière's disease: long-term results. Otolaryngol Head Neck Surg 1998;118:261-266.
15. Shirwany NA, Seidman MD, Tang W. Effect of transtympanic injection of steroids on cochlear blood flow, auditory sensitivity, and histology in the guinea pig. Am J Otol 1998;19:230-235.
16. Rauch SD. Intratympanic steroids for sensorineural hearing loss. Otolaryngol Clin North Am 2004;37:1061-1074.
17. Ryan AF, Pak K, Low W, et al. Immunological damage to the inner ear: current and future therapeutic strategies. Adv Otorhinolaryngol 2002;59:66-74.
18. Kakehata S, Sasaki A, Oji K, et al. Comparison of intratympanic and intravenous dexamethasone treatment on sudden sensorineural hearing loss with diabetes. Otol Neurotol 2006;27:604-608.
19. Heydt JL, Cunningham LL, Rubel EW, Coltrera MD. Round window gentamicin application: an inner ear hair cell damage protocol for the mouse. Hear Res 2004;192:65-74.