Dramatic reduction of PrPC level and glycosylation in peripheral nerves following PrP knock-out from Schwann cells does not prevent transmissible spongiform encephalopathy neuroinvasion

Journal of Neuroscience

Volumn 29, Issue 49, 2009, Pages 15445-15454

  Bradford, Barry M ^a   Tuzi, Nadia L ^b   Feltri, M Laura ^c   McCorquodale, Caroline ^a   Cancellotti, Enrico ^a   Manson, Jean C ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

PRION PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DOWN REGULATION; GLIA CELL; IN VIVO STUDY; INFECTION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PERIPHERAL NERVE; PERIPHERAL NERVOUS SYSTEM; PRION DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; SCHWANN CELL; SCRAPIE AGENT; SPECIES;

ANIMALS; BRAIN; GLYCOSYLATION; INFECTIOUS DISEASE INCUBATION PERIOD; KAPLAN-MEIERS ESTIMATE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PERIPHERAL NERVES; PRION DISEASES; PRPC PROTEINS; PRPSC PROTEINS; SCHWANN CELLS; SCIATIC NERVE; SCRAPIE; TIME FACTORS; VACUOLES;

EID: 71849106507     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4195-09.2009     Document Type: Article

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