메뉴 건너뛰기




Volumn 22, Issue 3, 2009, Pages 395-407

Advances in the biology and therapy of patients with chronic myeloid leukaemia

Author keywords

Chronic myeloid leukemia; Kinase inhibitors; Management; T315I mutation

Indexed keywords

4 (3 DIMETHYLAMINO 1 PYRROLIDINYLMETHYL) 3 TRIFLUOROMETHYL N [4 METHYL 3 [[4 (5 PYRIMIDINYL) 2 PYRIMIDINYL]AMINO]PHENYL]BENZAMIDE; 5 AZA 2' DEOXYCYTIDINE; ALPHA INTERFERON; BCR ABL PROTEIN; BOSUTINIB; CYTARABINE; DANUSERTIB; DASATINIB; HOMOHARRINGTONINE; IDARUBICIN; IMATINIB; NILOTINIB; OMACETAXINE; PANOBINOSTAT; PEGINTERFERON ALPHA; PEPTIDE VACCINE; PHA 739538; PROTEIN KINASE INHIBITOR; SORAFENIB; UNCLASSIFIED DRUG; VORINOSTAT; XL 228;

EID: 71849103177     PISSN: 15216926     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.beha.2009.09.002     Document Type: Review
Times cited : (28)

References (74)
  • 1
    • 32844461437 scopus 로고    scopus 로고
    • Chronic myeloid leukemia: why does it evolve from chronic phase to blast transformation?
    • Mughal T.I., and Goldman J.M. Chronic myeloid leukemia: why does it evolve from chronic phase to blast transformation?. Front Biosci 11 (2006) 198-208
    • (2006) Front Biosci , vol.11 , pp. 198-208
    • Mughal, T.I.1    Goldman, J.M.2
  • 2
    • 0032887283 scopus 로고    scopus 로고
    • Chronic myelogenous leukemia. Curable with early diagnosis and treatment
    • 157-159
    • Hill J.M., and Meehan K.R. Chronic myelogenous leukemia. Curable with early diagnosis and treatment. Postgrad Med 106 (1999) 149-152 157-159
    • (1999) Postgrad Med , vol.106 , pp. 149-152
    • Hill, J.M.1    Meehan, K.R.2
  • 3
    • 0033520092 scopus 로고    scopus 로고
    • Chronic myelogenous leukemia: biology and therapy
    • Faderl S., Talpaz M., Estrov Z., et al. Chronic myelogenous leukemia: biology and therapy. Ann Intern Med 131 (1999) 207-219
    • (1999) Ann Intern Med , vol.131 , pp. 207-219
    • Faderl, S.1    Talpaz, M.2    Estrov, Z.3
  • 4
    • 0032410635 scopus 로고    scopus 로고
    • Chronic myelogenous leukemia: molecular and cellular aspects
    • Pasternak G., Hochhaus A., Schultheis B., et al. Chronic myelogenous leukemia: molecular and cellular aspects. J Cancer Res Clin Oncol 124 (1998) 643-660
    • (1998) J Cancer Res Clin Oncol , vol.124 , pp. 643-660
    • Pasternak, G.1    Hochhaus, A.2    Schultheis, B.3
  • 5
    • 0015694748 scopus 로고
    • Letter: a new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining
    • Rowley J.D. Letter: a new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature 243 (1973) 290-293
    • (1973) Nature , vol.243 , pp. 290-293
    • Rowley, J.D.1
  • 6
    • 0034670036 scopus 로고    scopus 로고
    • The molecular biology of chronic myeloid leukemia
    • Deininger M.W., Goldman J.M., and Melo J.V. The molecular biology of chronic myeloid leukemia. Blood 96 (2000) 3343-3356
    • (2000) Blood , vol.96 , pp. 3343-3356
    • Deininger, M.W.1    Goldman, J.M.2    Melo, J.V.3
  • 7
    • 0029850508 scopus 로고    scopus 로고
    • Blastic transformation of p53-deficient bone marrow cells by p2lObcr/abl tyrosine kinase
    • Skorski T., Nieborowska-Skorska M., Wlodarski P., et al. Blastic transformation of p53-deficient bone marrow cells by p2lObcr/abl tyrosine kinase. Proc Natl Acad Sci USA 93 (1996) 13137-13142
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13137-13142
    • Skorski, T.1    Nieborowska-Skorska, M.2    Wlodarski, P.3
  • 8
    • 0029993450 scopus 로고    scopus 로고
    • Role of the INK4a locus in tumor suppression and cell mortality
    • Serrano M., Lee H., Chin L., et al. Role of the INK4a locus in tumor suppression and cell mortality. Cell 85 (1996) 2737
    • (1996) Cell , vol.85 , pp. 2737
    • Serrano, M.1    Lee, H.2    Chin, L.3
  • 9
    • 0033853391 scopus 로고    scopus 로고
    • Alterations ofP53 and RB genes and the evolution of the accelerated phase of chronic myeloid leukemia
    • Beck Z., Kiss A., Tóth F.D., et al. Alterations ofP53 and RB genes and the evolution of the accelerated phase of chronic myeloid leukemia. Leuk Lymphoma 38 (2000) 587-597
    • (2000) Leuk Lymphoma , vol.38 , pp. 587-597
    • Beck, Z.1    Kiss, A.2    Tóth, F.D.3
  • 10
    • 0001510491 scopus 로고    scopus 로고
    • The RB and p53 pathways in cancer
    • Sherr C., and McCormick F. The RB and p53 pathways in cancer. Cancer Cell 2 (2002) 103-112
    • (2002) Cancer Cell , vol.2 , pp. 103-112
    • Sherr, C.1    McCormick, F.2
  • 11
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
    • Druker B.J., Tamura S., Buchdunger E., et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 2 (1996) 561-566
    • (1996) Nat Med , vol.2 , pp. 561-566
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3
  • 12
    • 0033614446 scopus 로고    scopus 로고
    • Chronic myeloid leukemia
    • Sawyers C.L. Chronic myeloid leukemia. N Engl J Med 340 (1999) 1330-1340
    • (1999) N Engl J Med , vol.340 , pp. 1330-1340
    • Sawyers, C.L.1
  • 13
    • 36248942654 scopus 로고    scopus 로고
    • Chronic myeloid leukemia in 2007
    • Sessions J. Chronic myeloid leukemia in 2007. J Manag Care Pharm 13 (2007) 4-7
    • (2007) J Manag Care Pharm , vol.13 , pp. 4-7
    • Sessions, J.1
  • 14
    • 10744233716 scopus 로고    scopus 로고
    • Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
    • O'Brien S.G., Guilhot F., Larson R.A., et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 348 (2003) 994-1004
    • (2003) N Engl J Med , vol.348 , pp. 994-1004
    • O'Brien, S.G.1    Guilhot, F.2    Larson, R.A.3
  • 15
    • 33745102555 scopus 로고    scopus 로고
    • Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
    • Talpaz M., Shah N.P., Kantarjian H., et al. Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med 354 (2006) 2531-2541
    • (2006) N Engl J Med , vol.354 , pp. 2531-2541
    • Talpaz, M.1    Shah, N.P.2    Kantarjian, H.3
  • 16
    • 33745086350 scopus 로고    scopus 로고
    • Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL
    • Kantarjian H., Giles F., Wunderle L., et al. Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med 354 (2006) 2542-2551
    • (2006) N Engl J Med , vol.354 , pp. 2542-2551
    • Kantarjian, H.1    Giles, F.2    Wunderle, L.3
  • 17
    • 84907479333 scopus 로고    scopus 로고
    • NCCN: clinical practice guidelines in oncology
    • Version 1 www.nccn.org/index.asp
    • National Comprehensive Cancer Network. NCCN: clinical practice guidelines in oncology. Chronic Myelogenous Leuk (2009). http://www.nccn.org/index.asp Version 1 www.nccn.org/index.asp
    • (2009) Chronic Myelogenous Leuk
    • National Comprehensive Cancer Network1
  • 18
    • 33747154547 scopus 로고    scopus 로고
    • Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet
    • Baccarani M., Saglio G., Goldman J., et al. Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet. Blood 108 (2006) 1809-1820
    • (2006) Blood , vol.108 , pp. 1809-1820
    • Baccarani, M.1    Saglio, G.2    Goldman, J.3
  • 19
    • 68549097002 scopus 로고    scopus 로고
    • International randomized study of Interferon versus STI571 (IRIS) 7-year follow-up: sustained survival, low rate of transformation and increased rate of major molecular response (MMR) in patients (pts) with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib (IM)
    • O'Brien S.G., Guilhot F., Goldman J.M., et al. International randomized study of Interferon versus STI571 (IRIS) 7-year follow-up: sustained survival, low rate of transformation and increased rate of major molecular response (MMR) in patients (pts) with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib (IM). Blood 112 (2008) 76
    • (2008) Blood , vol.112 , pp. 76
    • O'Brien, S.G.1    Guilhot, F.2    Goldman, J.M.3
  • 20
    • 35448967331 scopus 로고    scopus 로고
    • Part I: mechanisms of resistance to imatinib in chronic myeloid leukaemia
    • Apperley J.F. Part I: mechanisms of resistance to imatinib in chronic myeloid leukaemia. Lancet Oncol 8 (2007) 1018-1029
    • (2007) Lancet Oncol , vol.8 , pp. 1018-1029
    • Apperley, J.F.1
  • 21
    • 33750077276 scopus 로고    scopus 로고
    • Frequency and clinical significance of BCR-ABL mutations in patients with chronic myeloid leukemia treated with imatinib mesylate
    • Jabbour E., Kantarjian H., Jones D., et al. Frequency and clinical significance of BCR-ABL mutations in patients with chronic myeloid leukemia treated with imatinib mesylate. Leukemia 20 (2006) 1767-1773
    • (2006) Leukemia , vol.20 , pp. 1767-1773
    • Jabbour, E.1    Kantarjian, H.2    Jones, D.3
  • 22
    • 65249185560 scopus 로고    scopus 로고
    • Mechanisms of primary and secondary resistance to imatinib in chronic myeloid leukemia
    • Quintás-Cardama A., Kantarjian H.M., and Cortes J.E. Mechanisms of primary and secondary resistance to imatinib in chronic myeloid leukemia. Cancer Control 16 (2009) 122-1231
    • (2009) Cancer Control , vol.16 , pp. 122-1231
    • Quintás-Cardama, A.1    Kantarjian, H.M.2    Cortes, J.E.3
  • 23
    • 43549116201 scopus 로고    scopus 로고
    • Discontinuation and dose modification of imatinib in clinical practice
    • Hamdan M.Y., Sanders L., Oliveria S., et al. Discontinuation and dose modification of imatinib in clinical practice. J Clin Oncol 25 (2007) 7045
    • (2007) J Clin Oncol , vol.25 , pp. 7045
    • Hamdan, M.Y.1    Sanders, L.2    Oliveria, S.3
  • 24
    • 43049104149 scopus 로고    scopus 로고
    • Molecular monitoring in chronic myeloid leukemia: response to tyrosine kinase inhibitors and prognostic implications
    • Jabbour E., Cortes J.E., and Kantarjian H.M. Molecular monitoring in chronic myeloid leukemia: response to tyrosine kinase inhibitors and prognostic implications. Cancer 112 (2008) 2112-2118
    • (2008) Cancer , vol.112 , pp. 2112-2118
    • Jabbour, E.1    Cortes, J.E.2    Kantarjian, H.M.3
  • 25
    • 33745603988 scopus 로고    scopus 로고
    • Monitoring CML patients responding to treatment with tyrosine kinase inhibitors - review and recommendations for 'harmonizing' current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results
    • Hughes T., Deininger M., Hochhaus A., et al. Monitoring CML patients responding to treatment with tyrosine kinase inhibitors - review and recommendations for 'harmonizing' current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results. Blood 108 (2006) 28-37
    • (2006) Blood , vol.108 , pp. 28-37
    • Hughes, T.1    Deininger, M.2    Hochhaus, A.3
  • 26
    • 34247869894 scopus 로고    scopus 로고
    • Management of patients with newly diagnosed chronic myeloid leukemia: opportunities and challenges
    • Jabbour E., Cortes J., O'Brien S., et al. Management of patients with newly diagnosed chronic myeloid leukemia: opportunities and challenges. Clin Lymphoma Myeloma 7 (2007) S51-S57
    • (2007) Clin Lymphoma Myeloma , vol.7
    • Jabbour, E.1    Cortes, J.2    O'Brien, S.3
  • 27
    • 60049092698 scopus 로고    scopus 로고
    • Efficacy of imatinib dose escalation in patients with chronic myeloid leukemia in chronic phase
    • Kantarjian H.M., Larson R.A., Guilhot F., et al. Efficacy of imatinib dose escalation in patients with chronic myeloid leukemia in chronic phase. Cancer 115 (2009) 551-560
    • (2009) Cancer , vol.115 , pp. 551-560
    • Kantarjian, H.M.1    Larson, R.A.2    Guilhot, F.3
  • 28
    • 64049099666 scopus 로고    scopus 로고
    • Imatinib mesylate dose escalation is associated with durable responses in patients with chronic myeloid leukemia post cytogenetic failure on standard-dose imatinib therapy
    • Jabbour E., Kantarjian H., O'Brien S., et al. Imatinib mesylate dose escalation is associated with durable responses in patients with chronic myeloid leukemia post cytogenetic failure on standard-dose imatinib therapy. Blood 113 (2008) 2154-2160
    • (2008) Blood , vol.113 , pp. 2154-2160
    • Jabbour, E.1    Kantarjian, H.2    O'Brien, S.3
  • 29
    • 71849092738 scopus 로고    scopus 로고
    • Sprycel dasatinib, package insert, 2007
    • Sprycel (dasatinib) [package insert]. 2007.
  • 30
    • 71849085181 scopus 로고    scopus 로고
    • Dasatinib prescribing information, May 2008.
    • Dasatinib prescribing information, May 2008.
  • 31
    • 33947280081 scopus 로고    scopus 로고
    • Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy
    • Hochhaus A., Kantarjian H.M., Baccarani M., et al. Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy. Blood 109 (2007) 2303-2309
    • (2007) Blood , vol.109 , pp. 2303-2309
    • Hochhaus, A.1    Kantarjian, H.M.2    Baccarani, M.3
  • 32
    • 60049093162 scopus 로고    scopus 로고
    • Dasatinib long-term efficacy in patients with chronic myeloid leukemia in chronic phase (CML-CP) with resistance or intolerance to imatinib: A two-year update of the START-C study
    • Cervantes F., Baccarani M., Lipton J., et al. Dasatinib long-term efficacy in patients with chronic myeloid leukemia in chronic phase (CML-CP) with resistance or intolerance to imatinib: A two-year update of the START-C study. Haematologica 93 (2008) 372
    • (2008) Haematologica , vol.93 , pp. 372
    • Cervantes, F.1    Baccarani, M.2    Lipton, J.3
  • 33
    • 63249112992 scopus 로고    scopus 로고
    • Dasatinib compared with high-dose imatinib in patients with chronic myelogenous leukemia in chronic phase (CML-CP) after failure of standard-dose imatinib - A two-year update of the START-R study
    • Rousselot P., Corm S., Paquette R., et al. Dasatinib compared with high-dose imatinib in patients with chronic myelogenous leukemia in chronic phase (CML-CP) after failure of standard-dose imatinib - A two-year update of the START-R study. Haematologica 93 (2008) 48
    • (2008) Haematologica , vol.93 , pp. 48
    • Rousselot, P.1    Corm, S.2    Paquette, R.3
  • 34
    • 34848876293 scopus 로고    scopus 로고
    • Dasatinib 50 mg or 70 mg BID compared to 100 mg or 140 mg QD in patients with CML in chronic phase (CP) who are resistant or intolerant to imatinib: One-year results of CA180034
    • Shah N.P., Kim D.W., Kantarjian H.M., et al. Dasatinib 50 mg or 70 mg BID compared to 100 mg or 140 mg QD in patients with CML in chronic phase (CP) who are resistant or intolerant to imatinib: One-year results of CA180034. J Clin Oncol 25 (2007) 358
    • (2007) J Clin Oncol , vol.25 , pp. 358
    • Shah, N.P.1    Kim, D.W.2    Kantarjian, H.M.3
  • 35
    • 71849109216 scopus 로고    scopus 로고
    • Tasigna nilotinib, package insert, 2007
    • Tasigna (nilotinib) [package insert]. 2007.
  • 36
    • 65649116169 scopus 로고    scopus 로고
    • Nilotinib in Chronic Myeloid Leukemia Patients in chronic phase (CML-CP) with imatinib resistance or intolerance: 2-year follow-up results of a phase 2 study
    • Kantarjian H.M., Giles F., Bhalla K.N., et al. Nilotinib in Chronic Myeloid Leukemia Patients in chronic phase (CML-CP) with imatinib resistance or intolerance: 2-year follow-up results of a phase 2 study. Blood 112 (2008) 1112
    • (2008) Blood , vol.112 , pp. 1112
    • Kantarjian, H.M.1    Giles, F.2    Bhalla, K.N.3
  • 37
    • 68249160747 scopus 로고    scopus 로고
    • Minimal cross-intolerance between nilotinib and imatinib in patients with imatinib-intolerant chronic myeloid leukemia in chronic phase (CML-CP) or accelerated phase (CML-AP)
    • Jabbour E., Kantarjian H.M., Baccarani M., et al. Minimal cross-intolerance between nilotinib and imatinib in patients with imatinib-intolerant chronic myeloid leukemia in chronic phase (CML-CP) or accelerated phase (CML-AP). Blood 112 (2008) 1103
    • (2008) Blood , vol.112 , pp. 1103
    • Jabbour, E.1    Kantarjian, H.M.2    Baccarani, M.3
  • 38
    • 65649138749 scopus 로고    scopus 로고
    • A Phase III, randomized, open-label study of 400 mg versus 800 mg of imatinib mesylate (IM) in patients (pts) with newly diagnosed, previously untreated chronic myeloid leukemia in chronic phase (CML-CP) using molecular endpoints: 1-year results of TOPS (Tyrosine Kinase Inhibitor Optimization and Selectivity) Study
    • Cortes J.E., Baccarani M., Guilhot F., et al. A Phase III, randomized, open-label study of 400 mg versus 800 mg of imatinib mesylate (IM) in patients (pts) with newly diagnosed, previously untreated chronic myeloid leukemia in chronic phase (CML-CP) using molecular endpoints: 1-year results of TOPS (Tyrosine Kinase Inhibitor Optimization and Selectivity) Study. Blood 112 (2008) 130-131
    • (2008) Blood , vol.112 , pp. 130-131
    • Cortes, J.E.1    Baccarani, M.2    Guilhot, F.3
  • 39
    • 65349141629 scopus 로고    scopus 로고
    • Cytogenetic and molecular response to imatinib in high risk (Sokal) chronic myeloid leukemia (CML): Results of an European LeukemiaNet prospective study comparing 400 mg and 800 mg front-line
    • Baccarani M., Castagnetti F., Simonsson B., et al. Cytogenetic and molecular response to imatinib in high risk (Sokal) chronic myeloid leukemia (CML): Results of an European LeukemiaNet prospective study comparing 400 mg and 800 mg front-line. Blood 112 (2008) 75
    • (2008) Blood , vol.112 , pp. 75
    • Baccarani, M.1    Castagnetti, F.2    Simonsson, B.3
  • 40
    • 65249163683 scopus 로고    scopus 로고
    • Efficacy of nilotinib (formerly AMN107) in patients (Pts) with newly diagnosed, previously untreated Philadelphia chromosome (Ph)-positive chronic myelogenous leukemia in early chronic phase (CML-CP)
    • Cortes J., O'Brien S., Jones D., et al. Efficacy of nilotinib (formerly AMN107) in patients (Pts) with newly diagnosed, previously untreated Philadelphia chromosome (Ph)-positive chronic myelogenous leukemia in early chronic phase (CML-CP). Blood 112 (2008) 170
    • (2008) Blood , vol.112 , pp. 170
    • Cortes, J.1    O'Brien, S.2    Jones, D.3
  • 41
    • 67349248447 scopus 로고    scopus 로고
    • High and early rates of cytogenetic and molecular response with nilotinib 800 mg daily as first line treatment of Ph-positive chronic myeloid leukemia in chronic phase: Results of a phase 2 trial of the GIMEMA CML Working Party
    • Rosti G., Castagnetti F., Poerio A., et al. High and early rates of cytogenetic and molecular response with nilotinib 800 mg daily as first line treatment of Ph-positive chronic myeloid leukemia in chronic phase: Results of a phase 2 trial of the GIMEMA CML Working Party. Blood 112 (2008) 73-74
    • (2008) Blood , vol.112 , pp. 73-74
    • Rosti, G.1    Castagnetti, F.2    Poerio, A.3
  • 42
    • 64549104848 scopus 로고    scopus 로고
    • Efficacy of dasatinib in patients (pts) with previously untreated chronic myelogenous leukemia (CML) in early chronic phase (CML-CP)
    • Cortes J., O'Brien S., Borthakur G., et al. Efficacy of dasatinib in patients (pts) with previously untreated chronic myelogenous leukemia (CML) in early chronic phase (CML-CP). Blood 112 (2008) 74
    • (2008) Blood , vol.112 , pp. 74
    • Cortes, J.1    O'Brien, S.2    Borthakur, G.3
  • 43
    • 0037439689 scopus 로고    scopus 로고
    • SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice
    • Golas J.M., Arndt K., Etienne C., et al. SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice. Cancer Res. 63 (2003) 375-381
    • (2003) Cancer Res. , vol.63 , pp. 375-381
    • Golas, J.M.1    Arndt, K.2    Etienne, C.3
  • 44
    • 65649108082 scopus 로고    scopus 로고
    • Efficacy and safety of bosutinib (SKI-606) in patients with chronic phase (CP) Ph+ chronic myelogenous leukemia (CML) with resistance or intolerance to imatinib
    • Cortes J., Kantarjian H.M., Kim D.W., et al. Efficacy and safety of bosutinib (SKI-606) in patients with chronic phase (CP) Ph+ chronic myelogenous leukemia (CML) with resistance or intolerance to imatinib. Blood 112 (2008) 1098
    • (2008) Blood , vol.112 , pp. 1098
    • Cortes, J.1    Kantarjian, H.M.2    Kim, D.W.3
  • 45
    • 39049164641 scopus 로고    scopus 로고
    • phase I study of INNO-406, a dual inhibitor of Abl and Lyn kinases, in adult patients with Philadelphia chromosome positive (Ph+) chronic myelogenous leukemia (CML) or acute lymphocytic leukemia (ALL) relapsed, refractory, or intolerant of imatinib
    • (abstract # 7046)
    • Craig A.R., Kantarjian H.M., Cortes J.E., et al. phase I study of INNO-406, a dual inhibitor of Abl and Lyn kinases, in adult patients with Philadelphia chromosome positive (Ph+) chronic myelogenous leukemia (CML) or acute lymphocytic leukemia (ALL) relapsed, refractory, or intolerant of imatinib. J Clin Oncol 25 (2007) 368s (abstract # 7046)
    • (2007) J Clin Oncol , vol.25
    • Craig, A.R.1    Kantarjian, H.M.2    Cortes, J.E.3
  • 46
    • 68949138161 scopus 로고    scopus 로고
    • + + Leukemias with either failure to multiple TKI therapies or with T315I mutation
    • + + Leukemias with either failure to multiple TKI therapies or with T315I mutation. Blood 112 (2008) 3232
    • (2008) Blood , vol.112 , pp. 3232
    • Cortes, J.1    Paquette, R.2    Talpaz, M.3
  • 47
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm S.M., Carter C., Tang L., et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 64 (2004) 7099-7109
    • (2004) Cancer Res. , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 48
    • 34548412863 scopus 로고    scopus 로고
    • The multikinase inhibitor sorafenib induces apoptosis in highly imatinib mesylate-resistant bcr/abl+ human leukemia cells in association with signal transducer and activator of transcription 5 inhibition and myeloid cell leukemia-1 down-regulation
    • Rahmani M., Nguyen T.K., Dent P., et al. The multikinase inhibitor sorafenib induces apoptosis in highly imatinib mesylate-resistant bcr/abl+ human leukemia cells in association with signal transducer and activator of transcription 5 inhibition and myeloid cell leukemia-1 down-regulation. Mol Pharmacol 72 (2007) 788-795
    • (2007) Mol Pharmacol , vol.72 , pp. 788-795
    • Rahmani, M.1    Nguyen, T.K.2    Dent, P.3
  • 49
    • 43249111278 scopus 로고    scopus 로고
    • Simultaneous targeting of Aurora kinases and Bcr-Abl kinase by the small molecule inhibitor PHA-739358 is effective against imatinib-resistant BCR-ABL mutations including T315I
    • Gontarewicz A., Balabanov S., Keller G., et al. Simultaneous targeting of Aurora kinases and Bcr-Abl kinase by the small molecule inhibitor PHA-739358 is effective against imatinib-resistant BCR-ABL mutations including T315I. Blood 111 (2008) 4355-4364
    • (2008) Blood , vol.111 , pp. 4355-4364
    • Gontarewicz, A.1    Balabanov, S.2    Keller, G.3
  • 50
    • 61849136570 scopus 로고    scopus 로고
    • PHA-739358, an aurora kinase inhibitor, induces clinical responses in chronic myeloid leukemia harboring T315I mutations of BCR-ABL
    • [abstract]
    • Paquette R.L., Shah N.P., Sawyers C.L., et al. PHA-739358, an aurora kinase inhibitor, induces clinical responses in chronic myeloid leukemia harboring T315I mutations of BCR-ABL. [abstract]. Blood 110 (2007) 1030
    • (2007) Blood , vol.110 , pp. 1030
    • Paquette, R.L.1    Shah, N.P.2    Sawyers, C.L.3
  • 51
    • 34347398067 scopus 로고    scopus 로고
    • Panobinostat. Histone deacetylase (HDAC) inhibitor, apoptosis inducer, oncolytic
    • Revill P., Mealy N., Serradell N., et al. Panobinostat. Histone deacetylase (HDAC) inhibitor, apoptosis inducer, oncolytic. Drugs Future 32 (2007) 315-322
    • (2007) Drugs Future , vol.32 , pp. 315-322
    • Revill, P.1    Mealy, N.2    Serradell, N.3
  • 52
    • 39749143465 scopus 로고    scopus 로고
    • Phase IA/II study of oral LBH589, a novel deacetylase inhibitor (DACi), administered on 2 schedules, in patients with advanced hematologic malignancies
    • [abstract]
    • Spencer A., Prince M., DeAngelo D.J., et al. Phase IA/II study of oral LBH589, a novel deacetylase inhibitor (DACi), administered on 2 schedules, in patients with advanced hematologic malignancies. [abstract]. Blood 110 (2007) 907
    • (2007) Blood , vol.110 , pp. 907
    • Spencer, A.1    Prince, M.2    DeAngelo, D.J.3
  • 53
    • 71849112081 scopus 로고    scopus 로고
    • Vorinostat synergistically potentiates MK-0457 lethality in chronic myelogenous leukemia (CML) cells sensitive and resistant to imatinib mesylate
    • [abstract]
    • Dai Y., Chen S., Venditti C.A., et al. Vorinostat synergistically potentiates MK-0457 lethality in chronic myelogenous leukemia (CML) cells sensitive and resistant to imatinib mesylate. [abstract]. Blood 110 (2007) 1041a
    • (2007) Blood , vol.110
    • Dai, Y.1    Chen, S.2    Venditti, C.A.3
  • 54
    • 33745888156 scopus 로고    scopus 로고
    • Combined effects of novel tyrosine kinase inhibitor AMN107 and histone deacetylase inhibitor LBH589 against Bcr-Abl expressing human leukemia cells
    • Fiskus W., Pranpat M., Bali P., et al. Combined effects of novel tyrosine kinase inhibitor AMN107 and histone deacetylase inhibitor LBH589 against Bcr-Abl expressing human leukemia cells. Blood 108 (2006) 645-652
    • (2006) Blood , vol.108 , pp. 645-652
    • Fiskus, W.1    Pranpat, M.2    Bali, P.3
  • 55
    • 34547161973 scopus 로고    scopus 로고
    • Synergistic interactions between vorinostat and sorafenib in chronic myelogenous leukemia cells involve Mcl-1 and p21CIP1 down-regulation
    • Dasmahapatra G., Yerram N., Dai Y., et al. Synergistic interactions between vorinostat and sorafenib in chronic myelogenous leukemia cells involve Mcl-1 and p21CIP1 down-regulation. Clin Cancer Res. 13 (2007) 4280-4290
    • (2007) Clin Cancer Res. , vol.13 , pp. 4280-4290
    • Dasmahapatra, G.1    Yerram, N.2    Dai, Y.3
  • 56
    • 67349210795 scopus 로고    scopus 로고
    • A phase I study of the combination of a DNA topoisomerase inhibitor, idarubicin, with the histone deacetylase inhibitor vorinostat, in advanced acute leukemia
    • [abstract]
    • Kadia T.M., Borthakur G., Wierda W., et al. A phase I study of the combination of a DNA topoisomerase inhibitor, idarubicin, with the histone deacetylase inhibitor vorinostat, in advanced acute leukemia. [abstract]. J Clin Oncol 25 18S (2007) 7066
    • (2007) J Clin Oncol , vol.25 , Issue.18 S , pp. 7066
    • Kadia, T.M.1    Borthakur, G.2    Wierda, W.3
  • 57
    • 0036534203 scopus 로고    scopus 로고
    • Simultaneous homoharringtonine and interferon-alpha in the treatment of patients with chronic-phase chronic myelogenous leukemia
    • O'Brien S., Talpaz M., Cortes J., et al. Simultaneous homoharringtonine and interferon-alpha in the treatment of patients with chronic-phase chronic myelogenous leukemia. Cancer 94 (2002) 2024-2032
    • (2002) Cancer , vol.94 , pp. 2024-2032
    • O'Brien, S.1    Talpaz, M.2    Cortes, J.3
  • 58
    • 0041887168 scopus 로고    scopus 로고
    • Results of triple therapy with interferon-alpha, cytarabine, and homoharringtonine, and the impact of adding imatinib to the treatment sequence in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in early chronic phase
    • O'Brien S., Giles F., Talpaz M., et al. Results of triple therapy with interferon-alpha, cytarabine, and homoharringtonine, and the impact of adding imatinib to the treatment sequence in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in early chronic phase. Cancer 98 (2003) 888-893
    • (2003) Cancer , vol.98 , pp. 888-893
    • O'Brien, S.1    Giles, F.2    Talpaz, M.3
  • 59
    • 67349147995 scopus 로고    scopus 로고
    • Multicenter open label study of subcutaneous (SC) omacetaxine (OMA) in imatinib (IM)-resistant chronic myeloid leukemia (CML) patients (Pts) with the T315I mutation
    • [abstract]
    • Cortes, Khoury H.J., Corm S., et al. Multicenter open label study of subcutaneous (SC) omacetaxine (OMA) in imatinib (IM)-resistant chronic myeloid leukemia (CML) patients (Pts) with the T315I mutation. [abstract]. J Clin Oncol 26 (2008) 7021
    • (2008) J Clin Oncol , vol.26 , pp. 7021
    • Cortes1    Khoury, H.J.2    Corm, S.3
  • 60
    • 13844312036 scopus 로고    scopus 로고
    • Effect of a p210 multipeptide vaccine associated with imatinib or interferon in patients with chronic myeloid leukaemia and persistent residual disease: a multicentre observational trial
    • Bocchia M., Gentili S., Abruzzese E., et al. Effect of a p210 multipeptide vaccine associated with imatinib or interferon in patients with chronic myeloid leukaemia and persistent residual disease: a multicentre observational trial. Lancet 365 (2005) 657-662
    • (2005) Lancet , vol.365 , pp. 657-662
    • Bocchia, M.1    Gentili, S.2    Abruzzese, E.3
  • 61
    • 0037962005 scopus 로고    scopus 로고
    • Results of decitabine (5′-aza-2′deoxycytidine) therapy in 130 patients with chronic myelogenous leukemia
    • Kantarjian H.M., O'Brien S., Cortes J., et al. Results of decitabine (5′-aza-2′deoxycytidine) therapy in 130 patients with chronic myelogenous leukemia. Cancer 98 (2003) 522-528
    • (2003) Cancer , vol.98 , pp. 522-528
    • Kantarjian, H.M.1    O'Brien, S.2    Cortes, J.3
  • 62
    • 21244431605 scopus 로고    scopus 로고
    • Phase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylate
    • Issa J.P., Gharibyan V., Cortes J., et al. Phase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylate. J Clin Oncol 23 (2005) 3948-3956
    • (2005) J Clin Oncol , vol.23 , pp. 3948-3956
    • Issa, J.P.1    Gharibyan, V.2    Cortes, J.3
  • 63
    • 70449334476 scopus 로고    scopus 로고
    • Randomized comparison of imatinib versus imatinib combination therapies in newly diagnosed chronic myeloid leukaemia (CML) patients in chronic phase (CP): first results of the Phase III (SPIRIT) Trial from the French CML Group (FI LMC)
    • Guilhot F., Mahon F.-X., Guilhot J., et al. Randomized comparison of imatinib versus imatinib combination therapies in newly diagnosed chronic myeloid leukaemia (CML) patients in chronic phase (CP): first results of the Phase III (SPIRIT) Trial from the French CML Group (FI LMC). Blood (ASH Annual Meeting Abstracts) 112 (Nov 2008) 183
    • (2008) Blood (ASH Annual Meeting Abstracts) , vol.112 , pp. 183
    • Guilhot, F.1    Mahon, F.-X.2    Guilhot, J.3
  • 64
    • 71849107929 scopus 로고    scopus 로고
    • Randomized clinical trial for the optimization of imatinib therapy by combination, dose escalation and transplantation. Designed first interim analysis of the German CML study IV
    • abs. 0478
    • Hehlmann R., Saussele S., Lauseker M., et al. Randomized clinical trial for the optimization of imatinib therapy by combination, dose escalation and transplantation. Designed first interim analysis of the German CML study IV. Haematologica 94 Suppl. 2 (2009) 193 abs. 0478
    • (2009) Haematologica , vol.94 , Issue.SUPPL. 2 , pp. 193
    • Hehlmann, R.1    Saussele, S.2    Lauseker, M.3
  • 65
    • 54049146732 scopus 로고    scopus 로고
    • Impact of prior imatinib mesylate on the outcome of hematopoietic cell transplantation for chronic myeloid leukemia
    • Lee S.J., Kukreja M., Wang T., et al. Impact of prior imatinib mesylate on the outcome of hematopoietic cell transplantation for chronic myeloid leukemia. Blood 112 8 (2008 Oct 15) 3500-3507
    • (2008) Blood , vol.112 , Issue.8 , pp. 3500-3507
    • Lee, S.J.1    Kukreja, M.2    Wang, T.3
  • 66
    • 33846925617 scopus 로고    scopus 로고
    • The effects of imatinib mesylate treatment before allogeneic transplantation for chronic myeloid leukemia
    • Oehler V.G., Gooley T., Snyder D.S., et al. The effects of imatinib mesylate treatment before allogeneic transplantation for chronic myeloid leukemia. Blood 109 4 (2007 Feb 15) 1782-1789
    • (2007) Blood , vol.109 , Issue.4 , pp. 1782-1789
    • Oehler, V.G.1    Gooley, T.2    Snyder, D.S.3
  • 67
    • 71849109984 scopus 로고    scopus 로고
    • Allogeneic hematopoietic stem cell transplantation (HSCT) in the imatinib-era: high survival rate following allogeneic HSCT after imatinib failure: results of the german CML study IV
    • Saussele S., Lauseker M., Gratwohl A., et al. Allogeneic hematopoietic stem cell transplantation (HSCT) in the imatinib-era: high survival rate following allogeneic HSCT after imatinib failure: results of the german CML study IV. Blood (ASH Annual Meeting Abstracts) 112 (Nov 2008) 448
    • (2008) Blood (ASH Annual Meeting Abstracts) , vol.112 , pp. 448
    • Saussele, S.1    Lauseker, M.2    Gratwohl, A.3
  • 68
    • 33747156914 scopus 로고    scopus 로고
    • Allogeneic stem cell transplantation for patients with chronic myeloid leukemia and acute lymphocytic leukemia after Bcr-Abl kinase mutation-related imatinib failure
    • Jabbour E., Cortes J., Kantarjian H.M., et al. Allogeneic stem cell transplantation for patients with chronic myeloid leukemia and acute lymphocytic leukemia after Bcr-Abl kinase mutation-related imatinib failure. Blood 108 (2006) 1421-1423
    • (2006) Blood , vol.108 , pp. 1421-1423
    • Jabbour, E.1    Cortes, J.2    Kantarjian, H.M.3
  • 69
    • 37049003546 scopus 로고    scopus 로고
    • Dynamics of BCR-ABL kinase domain mutations in chronic myeloid leukemia after sequential treatment with multiple tyrosine kinase inhibitors
    • Cortes J., Jabbour E., Kantarjian H., et al. Dynamics of BCR-ABL kinase domain mutations in chronic myeloid leukemia after sequential treatment with multiple tyrosine kinase inhibitors. Blood 110 (2007) 4005-4011
    • (2007) Blood , vol.110 , pp. 4005-4011
    • Cortes, J.1    Jabbour, E.2    Kantarjian, H.3
  • 70
    • 70350112985 scopus 로고    scopus 로고
    • Dasatinib efficacy in patients with chronic myelogenous leukemia in chronic phase (CML-CP) and pre-existing BCR-ABL mutations
    • abstract 449
    • Muller M.C., Cortes J., Kim D.W., et al. Dasatinib efficacy in patients with chronic myelogenous leukemia in chronic phase (CML-CP) and pre-existing BCR-ABL mutations. Blood 112 (2008) abstract 449
    • (2008) Blood , vol.112
    • Muller, M.C.1    Cortes, J.2    Kim, D.W.3
  • 71
    • 70249105789 scopus 로고    scopus 로고
    • Impact of Baseline BCR-ABL Mutations on Response to Nilotinib in Chronic Myeloid Leukemia Patients in Chronic Phase (CML-CP)
    • Hughes T., Saglio G., Branford S., et al. Impact of Baseline BCR-ABL Mutations on Response to Nilotinib in Chronic Myeloid Leukemia Patients in Chronic Phase (CML-CP). J Clin Oncol 27 25 (2009) 4204-4210
    • (2009) J Clin Oncol , vol.27 , Issue.25 , pp. 4204-4210
    • Hughes, T.1    Saglio, G.2    Branford, S.3
  • 72
    • 47249123747 scopus 로고    scopus 로고
    • Characteristics and outcomes of patients with chronic myeloid leukemia and T315I mutation following failure of imatinib mesylate therapy
    • Jabbour E., Kantarjian H., Jones D., et al. Characteristics and outcomes of patients with chronic myeloid leukemia and T315I mutation following failure of imatinib mesylate therapy. Blood 112 (2008) 53-55
    • (2008) Blood , vol.112 , pp. 53-55
    • Jabbour, E.1    Kantarjian, H.2    Jones, D.3
  • 73
    • 33846228789 scopus 로고    scopus 로고
    • Contribution of ABL kinase domain mutations to imatinib resistance in different subsets of Philadelphia positive patients: by the GIMEMA Working Party on Chronic Myeloid Leukemia
    • Soverini S., Colarossi S., Gnani A., et al. Contribution of ABL kinase domain mutations to imatinib resistance in different subsets of Philadelphia positive patients: by the GIMEMA Working Party on Chronic Myeloid Leukemia. Clin Cancer Res. 12 (2006) 7374-7379
    • (2006) Clin Cancer Res. , vol.12 , pp. 7374-7379
    • Soverini, S.1    Colarossi, S.2    Gnani, A.3
  • 74
    • 58149380741 scopus 로고    scopus 로고
    • Characteristics and outcome of patients with F317L BCR-ABL kinase domain mutation after therapy with tyrosine kinase inhibitors
    • Jabbour E., kantarjian H.M., Jones D., et al. Characteristics and outcome of patients with F317L BCR-ABL kinase domain mutation after therapy with tyrosine kinase inhibitors. Blood 112 (2008) 4839-4842
    • (2008) Blood , vol.112 , pp. 4839-4842
    • Jabbour, E.1    kantarjian, H.M.2    Jones, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.