Heparin/Heparan sulfate N-Sulfamidase from Flavobacterium heparinum: Structural and biochemical investigation of catalytic nitrogen-sulfur bond cleavage

Journal of Biological Chemistry

Volumn 284, Issue 50, 2009, Pages 35189-35200

  Myette, James R ^a,b   Soundararajan, Venkataramanan ^a   Behr, Jonathan ^a   Shriver, Zachary ^a   Raman, Rahul ^a   Sasisekharan, Ram ^a,c  

^a HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^b Momenta Pharmaceuticals Inc   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL STUDIES; BIOLOGICAL FUNCTIONS; BOND CLEAVAGES; DEGRADATION PATHWAYS; DEGRADING ENZYMES; FINE STRUCTURES; FLAVOBACTERIUM HEPARINUM; FUNCTIONAL DIVERSITY; GLUCOSAMINES; GLYCOSAMINOGLYCANS; HEPARAN SULFATES; HYDROLASES; IN-VITRO; KEY REGULATORS; MOLECULAR CLONING; MOLECULAR MODELING STUDIES; NITROGEN-SULFUR; RECOMBINANT EXPRESSION; SPECIFIC LOCATION; STRUCTURE-FUNCTION ANALYSIS; SUBSTRATE SPECIFICITY; SULFATASES; SULFATE GROUPS; SULFATED POLYSACCHARIDES;

BIOCHEMISTRY; BIOPOLYMERS; CATALYSTS; CLONING; DEGRADATION; ENZYMES; ESCHERICHIA COLI; FLUORINE CONTAINING POLYMERS; GLUCOSE; OLIGOSACCHARIDES; POLYSACCHARIDES; SULFUR;

SUBSTRATES;

2 O SULFATASE; 6 O SULFATASE; BACTERIAL ENZYME; GLUCURONYL HYDROLASE; HEPARAN SULFATE; HEPARAN SULFATE N SULFAMIDASE; HEPARIN; HYDROLASE; MONOSACCHARIDE; NITROGEN; OLIGOSACCHARIDE; SULFATASE; SULFUR; UNCLASSIFIED DRUG; UNSATURATED GLUCURONYL HYDROLASE;

AMINO ACID SEQUENCE; ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; ENZYME DEGRADATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ENZYMOLOGY; ESCHERICHIA COLI; EXPRESSION VECTOR; FLAVOBACTERIUM; FLAVOBACTERIUM HEPARINUM; MOLECULAR CLONING; MOLECULAR MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; CALCIUM; CATALYTIC DOMAIN; CLONING, MOLECULAR; FLAVOBACTERIUM; GLYCOSAMINOGLYCANS; HEPARIN; HEPARITIN SULFATE; HYDROLASES; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; NITROGEN; OLIGOSACCHARIDES; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SULFUR;

ESCHERICHIA COLI; PEDOBACTER HEPARINUS;

EID: 71749121265     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.053835     Document Type: Article

References (37)

1. Bernfield, M., Götte, M., Park, P. W., Reizes, O., Fitzgerald, M. L., Lincecum, J., and Zako, M. (1999) Annu. Rev. Biochem. 68, 729-777
2. Esko, J. D., and Selleck, S. B. (2002) Annu. Rev. Biochem. 71, 435-471
3. Sasisekharan, R., Raman, R., and Prabhakar, V. (2006) Annu. Rev. Biomed. Eng. 8, 181-231
4. Esko, J. D., and Lindahl, U. (2001) J. Clin. Invest. 108, 169-173
5. Prince, J. M., Klinowska, T. C., Marshman, E., Lowe, E. T., Mayer, U., Miner, J., Aberdam, D., Vestweber, D., Gusterson, B., and Streuli, C. H. (2002) Dev. Dyn. 223, 497-516
6. Lai, J. P., Chien, J. R., Moser, D. R., Staub, J. K., Aderca, I., Montoya, D. P., Matthews, T. A., Nagorney, D. M., Cunningham, J. M., Smith, D. I., Greene, E. L., Shridhar, V., and Roberts, L. R. (2004) Gastroenterology 126, 231-248
7. Sasisekharan, R., Shriver, Z., Venkataraman, G., and Narayanasami, U. (2002) Nat. Rev. Cancer 2, 521-528
8. Häcker, U., Nybakken, K., and Perrimon, N. (2005) Nat. Rev. Mol. Cell Biol. 6, 530-541
9. Liu, J., Shriver, Z., Pope, R. M., Thorp, S. C., Duncan, M. B., Copeland, R. J., Raska, C. S., Yoshida, K., Eisenberg, R. J., Cohen, G., Linhardt, R. J., and Sasisekharan, R. (2002) J. Biol. Chem. 277, 33456-33467
10. Vivès, R. R., Lortat-Jacob, H., and Fender, P. (2006) Curr. Gene Ther. 6, 35-44
11. Dietrich, C. P., Silva, M. E., and Michelacci, Y. M. (1973) J. Biol. Chem. 248, 6408-6415
12. Nakamura, T., Shibata, Y., and Fujimura, S. (1988) J. Clin. Microbiol. 26, 1070-1071
13. Kertesz, M. A. (2000) FEMS Microbiol. Rev. 24, 135-175
14. Sasisekharan, R., Venkataraman, G., Godavarti, R., Ernst, S., Cooney, C. L., and Langer, R. (1996) J. Biol. Chem. 271, 3124-3131
15. Shriver, Z., Liu, D., Hu, Y., and Sasisekharan, R. (1999) J. Biol. Chem. 274, 4082-4088
16. Sasisekharan, R., Leckband, D., Godavarti, R., Venkataraman, G., Cooney, C. L., and Langer, R. (1995) Biochemistry 34, 14441-14448
17. Ernst, S., Venkataraman, G., Winkler, S., Godavarti, R., Langer, R., Cooney, C. L., and Sasisekharan, R. (1996) Biochem. J. 315, 589-597
18. Myette, J. R., Shriver, Z., Claycamp, C., McLean, M. W., Venkataraman, G., and Sasisekharan, R. (2003) J. Biol. Chem. 278, 12157-12166
19. Myette, J. R., Soundararajan, V., Shriver, Z., Raman, R., and Sasisekharan, R. (2009) J. Biol. Chem. 284, 35177-35188
20. Raman, R., Myette, J. R., Shriver, Z., Pojasek, K., Venkataraman, G., and Sasisekharan, R. (2003) J. Biol. Chem. 278, 12167-12174
21. Bond, C. S., Clements, P. R., Ashby, S. J., Collyer, C. A., Harrop, S. J., Hopwood, J. J., and Guss, J. M. (1997) Structure 5, 277-289
22. Boltes, I., Czapinska, H., Kahnert, A., von Bulow, R., Dierks, T., Schmidt, B., von Figura, K., Kertesz, M. A., and Usón, I. (2001) Structure 9, 483-491
23. Dierks, T., Miech, C., Hummerjohann, J., Schmidt, B., Kertesz, M. A., and von Figura, K. (1998) J. Biol. Chem. 273, 25560-25564
24. Bateman, A., Birney, E., Durbin, R., Eddy, S. R., Howe, K. L., and Sonnhammer, E. L. (2000) Nucleic Acids Res. 28, 263-266
25. Nielsen, H., Engelbrecht, J., Brunak, S., and von Heijne, G. (1997) Protein Eng. 10, 1-6
26. Beil, S., Kehrli, H., James, P., Staudenmann, W., Cook, A. M., Leisinger, T., and Kertesz, M. A. (1995) Eur. J. Biochem. 229, 385-394
27. Morimoto-Tomita, M., Uchimura, K., Werb, Z., Hemmerich, S., and Rosen, S. D. (2002) J. Biol. Chem. 277, 49175-49185
28. Venkataraman, G., Shriver, Z., Raman, R., and Sasisekharan, R. (1999) Science 286, 537-542
29. Myette, J. R., Shriver, Z., Kiziltepe, T., McLean, M. W., Venkataraman, G., and Sasisekharan, R. (2002) Biochemistry 41, 7424-7434
30. Rhomberg, A. J., Ernst, S., Sasisekharan, R., and Biemann, K. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 4176-4181
31. Chen, F. T., and Evangelista, R. A. (1995) Anal. Biochem. 230, 273-280
32. Guda, C., Lu, S., Scheeff, E. D., Bourne, P. E., and Shindyalov, I. N. (2004) Nucleic Acids Res. 32, W100-W103
33. Maiti, R., Van Domselaar, G. H., Zhang, H., and Wishart, D. S. (2004) Nucleic Acids Res. 32, W590-W594
34. Hankin, D. M., Danopoulos, A. A., Wilkinson, G., Sweet, T. K., and Hursthouse, M. B. (1996) J. Chem. Soc. Dalton Trans. 21, 4063-4069
35. Hanson, S. R., Best, M. D., and Wong, C. H. (2004) Angew. Chem. Int. Ed. Engl. 43, 5736-5763
36. Lindahl, U., Bäckström, G., Thunberg, L., and Leder, I. G. (1980) Proc. Natl. Acad. Sci. U.S.A. 77, 6551-6555
37. Bruce, J. S., McLean, M. W., Long, W. F., and Williamson, F. B. (1985) Eur. J. Biochem. 148, 359-365