Evaluation of triazolamers as active site inhibitors of HIV-1 protease

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 21, 2009, Pages 6023-6026

  Jochim, Andrea L ^a   Miller, Stephen E ^a   Angelo, Nicholas G ^a   Arora, Paramjit S ^a  

^a NEW YORK UNIVERSITY   (United States)

Author keywords

Strand mimetics; Peptidomimetics; Protease inhibitor

Indexed keywords

A 74704; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; L 700417; PROTEINASE INHIBITOR; TRIAZOLAMER; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG CONFORMATION; DRUG EFFICACY; DRUG SCREENING; ENZYME ACTIVITY; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR DOCKING; PILOT STUDY; PROTEINASE INHIBITION;

ANTI-HIV AGENTS; CATALYTIC DOMAIN; COMPUTER SIMULATION; HIV PROTEASE; HIV PROTEASE INHIBITORS; HUMANS; SOFTWARE; TRIAZOLES;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 71749114881     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.09.049     Document Type: Article

References (21)

1. Hill D.J., Mio M.J., Prince R.B., Hughes T.S., and Moore J.S. Chem. Rev. 101 (2001) 3893
2. Horne W.S., and Gellman S.H. Acc. Chem. Res. 41 (2008) 1399
3. Seebach D., and Gardiner J. Acc. Chem. Res. 41 (2008) 1366
4. Smith A.B., Hirschmann R., Pasternak A., Akaishi R., Guzman M.C., Jones D.R., Keenan T.P., Sprengeler P.A., Darke P.L., Emini E.A., Holloway M.K., and Schleif W.A. J. Med. Chem. 37 (1994) 215
5. Reichelt A., and Martin S.F. Acc. Chem. Res. 39 (2006) 433
6. Stigers K.D., Soth M.J., and Nowick J.S. Curr. Opin. Chem. Biol. 3 (1999) 714
7. Davis J.M., Tsou L.K., and Hamilton A.D. Chem. Soc. Rev. 36 (2007) 326
8. Phillips S.T., Rezac M., Abel U., Kossenjans M., and Bartlett P.A. J. Am. Chem. Soc. 124 (2002) 58
9. Angelo N.G., and Arora P.S. J. Am. Chem. Soc. 127 (2005) 17134
10. Angelo N.G., and Arora P.S. J. Org. Chem. 72 (2007) 7963
11. Tyndall J.D., Nall T., and Fairlie D.P. Chem. Rev. 105 (2005) 973
12. Tsai J.H., Waldman A.S., and Nowick J.S. Bioorg. Med. Chem. 7 (1999) 29
13. Brik A., Alexandratos J., Lin Y.C., Elder J.H., Olson A.J., Wlodawer A., Goodsell D.S., and Wong C.H. ChemBioChem 6 (2005) 1167
14. Bone R., Vacca J.P., Anderson P.S., and Holloway M.K. J. Am. Chem. Soc. 113 (1991) 9382
15. Erickson J., Neidhart D.J., VanDrie J., Kempf D.J., Wang X.C., Norbeck D.W., Plattner J.J., Rittenhouse J.W., Turon M., Wideburg N., Kohlbrenner W.E., Simmer R., Helfrich R., Paul D.A., and Knigge M. Science 249 (1990) 521
16. Matayoshi E.D., Wang G.T., Krafft G.A., and Erickson J. Science 247 (1990) 954
17. Morris G.M., Goodsell D.S., Halliday R.S., Huey R., Hart W.E., Belew R.K., and Olson A.J. J. Comp. Chem. 19 (1998) 1639
18. Insight II, version 2000 ed.; Accelrys: San Diego, CA.
19. Sanner M.F. J. Mol. Graphics Modell. 17 (1999) 57
20. Gasteiger J., and Marsili M. Tetrahedron 36 (1980) 3219
21. Nakatani S., Hidaka K., Ami E., Nakahara K., Sato A., Nguyen J.T., Hamada Y., Hori Y., Ohnishi N., Nagai A., Kimura T., Hayashi Y., and Kiso Y. J. Med. Chem. 51 (2008) 2992