Pharmacological effects of amiodarone and dronedarone on cardiac thyroid hormone receptors

Thyroid and Heart Failure: From Pathophysiology to Clinics

Volumn , Issue , 2009, Pages 89-95

  Wiersinga, Wilmar M ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Amiodarone; Dronedarone; Electrocardiogram; Heart; Iodothyronine 51 deiodinase; LDL receptor; Liver; Myosin heavy chain; Receptor antagonist; Sarcoplasmic reticulum Ca2+ ATPase; Thyroid hormone receptor

Indexed keywords

EID: 71749097795     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-88-470-1143-4_9     Document Type: Chapter

References (29)

1. Singh BN, Vaughan Williams EM (1970) The effect of amiodarone, a new anti-anginal drug, on cardiac muscle. Br J Pharmacol 39:657-667
2. Klein I, Danzi S (2007) Thyroid disease and the heart. Circulation 116:1725-1735
3. Wiersinga WM (1997) Amiodarone and the thyroid. In: Weetman AP, Grossman A (ed) Pharmacotherapeutics of the thyroid gland. Handbook of experimental pharmacology, vol 128. Springer, Berlin, pp 225-287
4. Wegener FT, Ehrlich JR, Hohnloser SH (2006) Dronedarone: an emerging agent with rhythm-and rate-controlling effects. J Cardiovasc Electrophysiol 17(Suppl 2):S17-S20
5. Kahaly GJ, Dillman W (2005) Thyroid hormone action in the heart. Endocr Rev 26:704-728
6. 1-receptor protein. Endocrinology 134:1665-1670
7. 1-receptor protein. Mol Cell Endocrinol 112:15-19
8. Van Beeren HC, Jong WM, Kaptein E et al (2003) Dronedarone acts as a selective inhibitor of 3, 5, 31-triiodothyronine binding to thyroid hormone receptor-alpha 1: in vitro and in vivo evidence. Endocrinology 144:552-558
9. 1α- triiodothyronine binding to the alpha 1-and beta 1-thyroid hormone receptor by amiodarone analogs. Endocrinology 137:2807-2814
10. Van Beeren HC, Bakker O, Chatterjee VK, Wiersinga WM (1999) Effect of mutations in the beta 1-thyroid hormone receptor on the inhibition of T3 binding by desethylamio-darone. FEBS Lett 450:35-38
11. Van Beeren HC, Bakker O, Wiersinga WM (2000) De-sethylamiodarone interferes with the binding of co-activator GRIP to the beta 1 thyroid hormone receptor. FEBS Lett 481:213-216
12. Bogazzi F, Bartalena L, Brogioni S et al (2001) Desethy-lamiodarone antagonizes the effect of thyroid hormone at the molecular level. Eur J Endocrinol 145:59-64
13. Plomp TA, Wiersinga WM, Maes RA (1985) Tissue distribution of amiodarone and desethylamiodarone in rats after repeated oral administration of various amiodarone dosages. Arzneimittelforschung 35:1805-1810
14. Schröder-van der Elst JP, van der Heide D (1990) Thyrox-ine, T3, and reverse T3 concentrations in several tissues of the rat: effects of amiodarone and desethylamiodarone on thyroid hormone metabolism. Endocrinology 127:1656-1664
15. Stoykov I, Van Beeren HC, Moorman AF et al (2007) Effect of amiodarone and dronedarone administration in rats on thyroid hormone-dependent gene expression in different cardiac components. Eur J Endocrinol 156:695-702
16. Meese R, Smitherman TC, Croft CH et al (1985) Effect of peripheral thyroid hormone metabolism on cardiac arrhythmias. Am J Cardiol 55:849-851
17. Hudig F, Bakker O, Wiersinga WM (1998) Amiodarone decreases gene expression of low-density lipoprotein receptor at both the mRNA and the protein level. Metabolism 47:1052-1057
18. Bakker O, Hudig F, Meyssen S, Wiersinga WM (1998) Effects of triiodothyronine and amiodarone on the promo-tor of the human LDL receptor gene. Biochem Biophys Res Commun 249:517-521
19. Yu J, Koenig RJ (2000) Regulation of hepatocyte thyroxine 5'-deiodinase by T3 and nuclear receptor coactivators as a model of the sick euthyroid syndrome. J Biol Chem 275:38296-38301
20. Swanson EA, Gloss B, Belke D et al (2003) Cardiac expression and function of thyroid hormone receptor ß and its PV mutant. Endocrinology 144:4820-4825
21. 1 deficient mice is an intrinsic defect. Am J Physiol 275:R640-R646
22. Gloss B, Trost S, Bluhm W et al (2001) Cardiac ion channel expression and contractile function in mice with deletion of thyroid hormone receptor alpha or beta. Endocrinology 142:544-550
23. Pantos C, Mourouzis I, Malliopoulou V et al (2005) Dronedarone administration prevents body weight gain and increases tolerance of the heart to ischemic stress: a possible involvement of thyroid hormone receptor α1. Thyroid 15:16-23
24. Sun W. Sarma JS, Singh BN (1999) Electrophysiological effects of dronedarone (SR33589), a noniodinated benzofuran derivative, in the rabbit heart: comparison with amio-darone. Circulation 100:2276-2281
25. Danzi S, Ojamaa K, Klein I (2003) Triiodothyronine-me-diated myosin heavy chain gene transcription in the heart. Am J Physiol Heart Circ Physiol 284:H2255-H2262
26. Franklyn JA, Green NK, Gammage MD et al (1989) Regulation of α-and β-myosin heavy chain messenger RNAs in the myocardium by amiodarone and by thyroid status. Clin Sci 76:463-467
27. Kinugawa K, Yonekura K, Ribeiro RCJ et al (2001) Regulation of thyroid hormone receptor isoforms in physiological and pathological cardiac hypertrophy. Circ Res 89:591-598
28. Bagchi N, Brown TR, Schneider DS, Benerjee SK (1987) Effect of amiodarone on the rat heart myosin isoenzymes. Circ Res 60:621-625
29. Pantos C, Mourouzis I, Xinaris C et al (2008) Thyroid hormone and "cardiac metamorphosis": potential therapeutic implications. Pharmacol Ther 118:277-294