Effect of the structure of adenosine mimic of bisubstrate-analog inhibitors on their activity towards basophilic protein kinases

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 21, 2009, Pages 6098-6101

  Enkvist, Erki ^a   Kriisa, Marie ^a   Roben, Mart ^a   Kadak, Grete ^a   Raidaru, Gerda ^a   Uri, Asko ^a  

^a UNIVERSITY OF TARTU   (Estonia)

Author keywords

AGC kinases; Bisubstrate inhibitors; Oligoarginine; PKA; PKB Akt; Protein kinases; ROCK

Indexed keywords

ADENOSINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; PROTEIN KINASE C GAMMA; PROTEIN KINASE INHIBITOR; TRIAZOLE DERIVATIVE;

ARTICLE; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME INHIBITION;

ADENOSINE; ARGININE; BINDING SITES; CYCLIC AMP-DEPENDENT PROTEIN KINASES; PEPTIDES; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PYRIMIDINES; RHO-ASSOCIATED KINASES; THIOPHENES;

EID: 71749091672     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.09.026     Document Type: Article

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