Stepwise combinatorial evolution of Akt bisubstrate inhibitors

ChemBioChem

Volumn 9, Issue 4, 2008, Pages 507-509

  Lee, Jung Hwan ^a   Kumar, Sanjai ^a   Lawrence, David S ^a,b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b University of North Carolina at Chapel Hill   (United States)

Author keywords

Bisubstrate inhibitor; Combinatorial chemistry; Phosphorylation; Protein kinase; Signal transduction

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALANYLARGINYLARGINYLGLYCYLALANYLLEUCYLARGINYLGLYCYLALANINE; PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG; PROTEIN KINASE B;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; COMPETITIVE INHIBITION; ENZYME INHIBITION; ENZYME SUBSTRATE; INHIBITION KINETICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MODIFICATION; STRUCTURE ACTIVITY RELATION; CHEMISTRY; COMBINATORIAL CHEMISTRY; DRUG ANTAGONISM; ENZYME SPECIFICITY; METABOLISM; MOLECULAR GENETICS; PHENOTYPE; SYNTHESIS;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; COMBINATORIAL CHEMISTRY TECHNIQUES; MOLECULAR SEQUENCE DATA; PHENOTYPE; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; SUBSTRATE SPECIFICITY;

EID: 40949118573     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200700583     Document Type: Article

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