Optimising metabolic stability in lipophilic chemical space: The identification of a metabolically stable pyrazolopyrimidine CRF-1 receptor antagonist

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 21, 2009, Pages 6144-6147

  Miller, Duncan C ^a   Klute, Wolfgang ^a   Calabrese, Andrew ^a   Brown, Alan D ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Antagonist; Corticotrophin releasing factor 1; G protein coupled receptor; Metabolic stability

Indexed keywords

ANTALARMIN; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1;

ANIMAL CELL; ARTICLE; DRUG CONFORMATION; DRUG DESIGN; DRUG MECHANISM; DRUG STABILITY; DRUG STRUCTURE; LIPOPHILICITY; LIVER MICROSOME; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; HUMANS; LIGANDS; MICROSOMES, LIVER; PYRIMIDINES; RATS; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 71749088604     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.09.016     Document Type: Article

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