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Volumn 124, Issue 5, 2009, Pages 873-880

Management of chronic obstructive pulmonary disease: Moving beyond the asthma algorithm

Author keywords

2 agonists; airflow obstruction; anticholinergics; antioxidants; asthma; bronchodilators; Chronic obstructive pulmonary disease; home oxygen; immunization; inhaled corticosteroids; long acting bronchodilators; mucolytics; oral corticosteroids; pulmonary rehabilitation; smoking cessation

Indexed keywords

ACETYLCYSTEINE; ANTIBIOTIC AGENT; ANTIINFLAMMATORY AGENT; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BRONCHODILATING AGENT; C REACTIVE PROTEIN; CHOLINERGIC RECEPTOR BLOCKING AGENT; CORTICOSTEROID; DORNASE ALFA; FLUTICASONE; FLUTICASONE PROPIONATE; FLUTICASONE PROPIONATE PLUS SALMETEROL; INFLUENZA VACCINE; IPRATROPIUM BROMIDE; MUCOLYTIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; PNEUMOCOCCUS VACCINE; PREDNISOLONE; ROFLUMILAST; SALMETEROL; STEROID; TIOTROPIUM BROMIDE; TRIAMCINOLONE;

EID: 71749083633     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2009.09.040     Document Type: Review
Times cited : (17)

References (104)
  • 1
    • 4143051640 scopus 로고    scopus 로고
    • Burden and clinical features of chronic obstructive pulmonary disease (COPD)
    • Pauwels R.A., and Rabe K.F. Burden and clinical features of chronic obstructive pulmonary disease (COPD). Lancet 364 (2004) 613-620
    • (2004) Lancet , vol.364 , pp. 613-620
    • Pauwels, R.A.1    Rabe, K.F.2
  • 2
    • 58149242734 scopus 로고    scopus 로고
    • The danger within: endogenous danger signals, atopy and asthma
    • Willart M.A., and Lambrecht B.N. The danger within: endogenous danger signals, atopy and asthma. Clin Exp Allergy 39 (2009) 12-19
    • (2009) Clin Exp Allergy , vol.39 , pp. 12-19
    • Willart, M.A.1    Lambrecht, B.N.2
  • 3
    • 22544455677 scopus 로고    scopus 로고
    • Lifetime environmental tobacco smoke exposure and the risk of chronic obstructive pulmonary disease
    • Eisner M.D., Balmes J., Katz P.P., Trupin L., Yelin E.H., and Blanc P.D. Lifetime environmental tobacco smoke exposure and the risk of chronic obstructive pulmonary disease. Environ Health 4 (2005) 7
    • (2005) Environ Health , vol.4 , pp. 7
    • Eisner, M.D.1    Balmes, J.2    Katz, P.P.3    Trupin, L.4    Yelin, E.H.5    Blanc, P.D.6
  • 4
    • 35348974996 scopus 로고    scopus 로고
    • Biomass fuels are the probable risk factor for chronic obstructive pulmonary disease in rural South China
    • Liu S., Zhou Y., Wang X., Wang D., Lu J., Zheng J., et al. Biomass fuels are the probable risk factor for chronic obstructive pulmonary disease in rural South China. Thorax 2007 (2007) 889-897
    • (2007) Thorax , vol.2007 , pp. 889-897
    • Liu, S.1    Zhou, Y.2    Wang, X.3    Wang, D.4    Lu, J.5    Zheng, J.6
  • 6
    • 1542399601 scopus 로고    scopus 로고
    • The impact of smoking cessation on respiratory symptoms, lung function, airway hyperresponsiveness and inflammation
    • Willemse B.W., Postma D.S., Timens W., and ten Hacken N.H. The impact of smoking cessation on respiratory symptoms, lung function, airway hyperresponsiveness and inflammation. Eur Respir J 23 (2004) 464-476
    • (2004) Eur Respir J , vol.23 , pp. 464-476
    • Willemse, B.W.1    Postma, D.S.2    Timens, W.3    ten Hacken, N.H.4
  • 7
    • 55849148482 scopus 로고    scopus 로고
    • The cytokine network in asthma and chronic obstructive pulmonary disease
    • Barnes P.J. The cytokine network in asthma and chronic obstructive pulmonary disease. J Clin Invest 118 (2008) 3546-3556
    • (2008) J Clin Invest , vol.118 , pp. 3546-3556
    • Barnes, P.J.1
  • 8
    • 0026010030 scopus 로고
    • Comparison of a β2-agonist, terbutaline, with an inhaled corticosteroid, budesonide, in newly detected asthma
    • Haahtela T., Järvinen M., Kava T., Kiviranta K., Koskinen S., Lehtonen K., et al. Comparison of a β2-agonist, terbutaline, with an inhaled corticosteroid, budesonide, in newly detected asthma. N Engl J Med 325 (1991) 388-392
    • (1991) N Engl J Med , vol.325 , pp. 388-392
    • Haahtela, T.1    Järvinen, M.2    Kava, T.3    Kiviranta, K.4    Koskinen, S.5    Lehtonen, K.6
  • 9
    • 0028023279 scopus 로고
    • Effects of reducing or discontinuing inhaled budesonide in patients with mild asthma
    • Haahtela T., Järvinen M., Kava T., Kiviranta K., Koskinen S., Lehtonen K., et al. Effects of reducing or discontinuing inhaled budesonide in patients with mild asthma. N Engl J Med 331 (1994) 700-705
    • (1994) N Engl J Med , vol.331 , pp. 700-705
    • Haahtela, T.1    Järvinen, M.2    Kava, T.3    Kiviranta, K.4    Koskinen, S.5    Lehtonen, K.6
  • 10
    • 0026788313 scopus 로고
    • Effects of 22 months of treatment with inhaled corticosteroids and/or beta-2-agonists on lung function, airway responsiveness, and symptoms in children with asthma
    • van Essen-Zandvliet E.E., Hughes M.D., Waalkens H.J., Duiverman E.J., Pocock S.J., and Kerrebijn K.F. Effects of 22 months of treatment with inhaled corticosteroids and/or beta-2-agonists on lung function, airway responsiveness, and symptoms in children with asthma. Am Rev Respir Dis 146 (1992) 547-554
    • (1992) Am Rev Respir Dis , vol.146 , pp. 547-554
    • van Essen-Zandvliet, E.E.1    Hughes, M.D.2    Waalkens, H.J.3    Duiverman, E.J.4    Pocock, S.J.5    Kerrebijn, K.F.6
  • 11
    • 0026474682 scopus 로고
    • A comparison of bronchodilator therapy with or without inhaled corticosteroid therapy for obstructive airways disease. Dutch Chronic Non-Specific Lung Disease Study Group
    • Kerstjens H.A., Brand P.L., Hughes M.D., Robinson N.J., Postma D.S., Sluiter H.J., et al. A comparison of bronchodilator therapy with or without inhaled corticosteroid therapy for obstructive airways disease. Dutch Chronic Non-Specific Lung Disease Study Group. N Engl J Med 327 (1992) 1413-1419
    • (1992) N Engl J Med , vol.327 , pp. 1413-1419
    • Kerstjens, H.A.1    Brand, P.L.2    Hughes, M.D.3    Robinson, N.J.4    Postma, D.S.5    Sluiter, H.J.6
  • 12
    • 0025036349 scopus 로고
    • Effect of long-term treatment with an inhaled corticosteroid on airway hyperresponsiveness and clinical asthma in nonsteroid-dependent asthmatics
    • Juniper E.F., Kline P.A., Vanzielehgem M.A., Ramsdale E.H., O'Byrne P.M., and Hargreave F.E. Effect of long-term treatment with an inhaled corticosteroid on airway hyperresponsiveness and clinical asthma in nonsteroid-dependent asthmatics. Am Rev Respir Dis 142 (1990) 832-836
    • (1990) Am Rev Respir Dis , vol.142 , pp. 832-836
    • Juniper, E.F.1    Kline, P.A.2    Vanzielehgem, M.A.3    Ramsdale, E.H.4    O'Byrne, P.M.5    Hargreave, F.E.6
  • 13
    • 0034601431 scopus 로고    scopus 로고
    • Low-dose inhaled corticosteroids and the prevention of death from asthma
    • Suissa S., Ernst P., Benayoun S., Baltzan M., and Cai B. Low-dose inhaled corticosteroids and the prevention of death from asthma. N Engl J Med 343 (2000) 332-336
    • (2000) N Engl J Med , vol.343 , pp. 332-336
    • Suissa, S.1    Ernst, P.2    Benayoun, S.3    Baltzan, M.4    Cai, B.5
  • 14
    • 0037471787 scopus 로고    scopus 로고
    • Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial
    • Pauwels R.A., Pedersen S., Busse W.W., Tan W.C., Chen Y.Z., Ohlsson S.V., et al. Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial. Lancet 361 (2003) 1071-1076
    • (2003) Lancet , vol.361 , pp. 1071-1076
    • Pauwels, R.A.1    Pedersen, S.2    Busse, W.W.3    Tan, W.C.4    Chen, Y.Z.5    Ohlsson, S.V.6
  • 15
    • 0037097883 scopus 로고    scopus 로고
    • The effects of inhaled fluticasone on airway inflammation in chronic obstructive pulmonary disease: a double-blind, placebo-controlled biopsy study
    • Hattotuwa K.L., Gizycki M.J., Ansari T.W., Jeffery P.K., and Barnes N.C. The effects of inhaled fluticasone on airway inflammation in chronic obstructive pulmonary disease: a double-blind, placebo-controlled biopsy study. Am J Respir Crit Care Med 165 (2002) 1592-1596
    • (2002) Am J Respir Crit Care Med , vol.165 , pp. 1592-1596
    • Hattotuwa, K.L.1    Gizycki, M.J.2    Ansari, T.W.3    Jeffery, P.K.4    Barnes, N.C.5
  • 17
    • 0030052682 scopus 로고    scopus 로고
    • Effect of fluticasone propionate on sputum of patients with chronic bronchitis and emphysema
    • Llewellyn-Jones C.G., Harris T.A., and Stockley R.A. Effect of fluticasone propionate on sputum of patients with chronic bronchitis and emphysema. Am J Respir Crit Care Med 153 (1996) 616-621
    • (1996) Am J Respir Crit Care Med , vol.153 , pp. 616-621
    • Llewellyn-Jones, C.G.1    Harris, T.A.2    Stockley, R.A.3
  • 18
    • 0032696013 scopus 로고    scopus 로고
    • Effect of high dose inhaled steroid on cells, cytokines, and proteases in induced sputum in chronic obstructive pulmonary disease
    • Culpitt S.V., Maziak W., Loukidis S., Nightingale J.A., Matthews J.L., and Barnes P.J. Effect of high dose inhaled steroid on cells, cytokines, and proteases in induced sputum in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 160 (1999) 1635-1639
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 1635-1639
    • Culpitt, S.V.1    Maziak, W.2    Loukidis, S.3    Nightingale, J.A.4    Matthews, J.L.5    Barnes, P.J.6
  • 19
    • 20144382091 scopus 로고    scopus 로고
    • Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease
    • Brightling C.E., McKenna S., Hargadon B., Birring S., Green R., Siva R., et al. Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease. Thorax 60 (2005) 193-198
    • (2005) Thorax , vol.60 , pp. 193-198
    • Brightling, C.E.1    McKenna, S.2    Hargadon, B.3    Birring, S.4    Green, R.5    Siva, R.6
  • 20
    • 0026683015 scopus 로고
    • Aerosolized beclomethasone in chronic bronchitis. Improved pulmonary function and diminished airway inflammation
    • Thompson A.B., Mueller M.B., Heires A.J., Bohling T.L., Daughton D., Yancey S.W., et al. Aerosolized beclomethasone in chronic bronchitis. Improved pulmonary function and diminished airway inflammation. Am Rev Respir Dis 146 (1992) 389-395
    • (1992) Am Rev Respir Dis , vol.146 , pp. 389-395
    • Thompson, A.B.1    Mueller, M.B.2    Heires, A.J.3    Bohling, T.L.4    Daughton, D.5    Yancey, S.W.6
  • 21
    • 28044442520 scopus 로고    scopus 로고
    • The effect of inhaled corticosteroids on bronchoalveolar lavage cells and IL-8 levels in stable COPD patients
    • Ozol D., Aysan T., Solak Z.A., Mogulkoc N., Veral A., and Sebik F. The effect of inhaled corticosteroids on bronchoalveolar lavage cells and IL-8 levels in stable COPD patients. Respir Med 99 (2005) 1494-1500
    • (2005) Respir Med , vol.99 , pp. 1494-1500
    • Ozol, D.1    Aysan, T.2    Solak, Z.A.3    Mogulkoc, N.4    Veral, A.5    Sebik, F.6
  • 22
    • 4644230621 scopus 로고    scopus 로고
    • Effects of fluticasone on systemic markers of inflammation in chronic obstructive pulmonary disease
    • Sin D.D., Lacy P., York E., and Man S.F. Effects of fluticasone on systemic markers of inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 170 (2004) 760-765
    • (2004) Am J Respir Crit Care Med , vol.170 , pp. 760-765
    • Sin, D.D.1    Lacy, P.2    York, E.3    Man, S.F.4
  • 23
    • 27144453619 scopus 로고    scopus 로고
    • Effects of inhaled HFA beclomethasone on pulmonary function and symptoms in patients with chronic obstructive pulmonary disease
    • John M., Bosse S., Oltmanns U., Schumacher A., and Witt C. Effects of inhaled HFA beclomethasone on pulmonary function and symptoms in patients with chronic obstructive pulmonary disease. Respir Med 99 (2005) 1418-1424
    • (2005) Respir Med , vol.99 , pp. 1418-1424
    • John, M.1    Bosse, S.2    Oltmanns, U.3    Schumacher, A.4    Witt, C.5
  • 24
    • 57049135358 scopus 로고    scopus 로고
    • Inhaled corticosteroids in patients with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis
    • Drummond M.B., Dasenbrook E.C., Pitz M.W., Murphy D.J., and Fan E. Inhaled corticosteroids in patients with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis. JAMA 300 (2008) 2407-2416
    • (2008) JAMA , vol.300 , pp. 2407-2416
    • Drummond, M.B.1    Dasenbrook, E.C.2    Pitz, M.W.3    Murphy, D.J.4    Fan, E.5
  • 25
    • 0033614639 scopus 로고    scopus 로고
    • Long-term effect of inhaled budesonide in mild and moderate chronic obstructive pulmonary disease: a randomised controlled trial
    • Vestbo J., Sorensen T., Lange P., Brix A., Torre P., and Viskum K. Long-term effect of inhaled budesonide in mild and moderate chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 353 (1999) 1819-1823
    • (1999) Lancet , vol.353 , pp. 1819-1823
    • Vestbo, J.1    Sorensen, T.2    Lange, P.3    Brix, A.4    Torre, P.5    Viskum, K.6
  • 26
    • 0345188819 scopus 로고    scopus 로고
    • Long-term Treatment with Inhaled Budesonide in Persons with Mild Chronic Obstructive Pulmonary Disease Who Continue Smoking. European Respiratory Society Study on Chronic Obstructive Pulmonary Disease
    • Pauwels R.A., Lofdahl C.G., Laitinen L.A., Schouten J.P., Postma D.S., Pride N.B., et al. Long-term Treatment with Inhaled Budesonide in Persons with Mild Chronic Obstructive Pulmonary Disease Who Continue Smoking. European Respiratory Society Study on Chronic Obstructive Pulmonary Disease. N Engl J Med 340 (1999) 1948-1953
    • (1999) N Engl J Med , vol.340 , pp. 1948-1953
    • Pauwels, R.A.1    Lofdahl, C.G.2    Laitinen, L.A.3    Schouten, J.P.4    Postma, D.S.5    Pride, N.B.6
  • 27
    • 0034643610 scopus 로고    scopus 로고
    • Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial
    • Burge P.S., Calverley P.M., Jones P.W., Spencer S., Anderson J.A., and Maslen T.K. Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial. BMJ 320 (2000) 1297-1303
    • (2000) BMJ , vol.320 , pp. 1297-1303
    • Burge, P.S.1    Calverley, P.M.2    Jones, P.W.3    Spencer, S.4    Anderson, J.A.5    Maslen, T.K.6
  • 28
    • 0034727828 scopus 로고    scopus 로고
    • Effect of inhaled triamcinolone on the decline in pulmonary function in chronic obstructive pulmonary disease
    • The Lung Health Study Research Group
    • The Lung Health Study Research Group. Effect of inhaled triamcinolone on the decline in pulmonary function in chronic obstructive pulmonary disease. N Engl J Med 343 (2000) 1902-1909
    • (2000) N Engl J Med , vol.343 , pp. 1902-1909
  • 30
    • 48949103222 scopus 로고    scopus 로고
    • Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH study
    • Celli B.R., Thomas N.E., Anderson J.A., Ferguson G.T., Jenkins C.R., Jones P.W., et al. Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH study. Am J Respir Crit Care Med 178 (2008) 332-338
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 332-338
    • Celli, B.R.1    Thomas, N.E.2    Anderson, J.A.3    Ferguson, G.T.4    Jenkins, C.R.5    Jones, P.W.6
  • 31
    • 0036063208 scopus 로고    scopus 로고
    • The effects of inhaled corticosteroids in chronic obstructive pulmonary disease: a systematic review of randomized placebo-controlled trials
    • Alsaeedi A., Sin D.D., and McAlister F.A. The effects of inhaled corticosteroids in chronic obstructive pulmonary disease: a systematic review of randomized placebo-controlled trials. Am J Med 113 (2002) 59-65
    • (2002) Am J Med , vol.113 , pp. 59-65
    • Alsaeedi, A.1    Sin, D.D.2    McAlister, F.A.3
  • 32
    • 16444363130 scopus 로고    scopus 로고
    • Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary updated 2003
    • discussion 103-4
    • Fabbri L., Pauwels R.A., and Hurd S.S. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary updated 2003. COPD 1 (2004) 105-141 discussion 103-4
    • (2004) COPD , vol.1 , pp. 105-141
    • Fabbri, L.1    Pauwels, R.A.2    Hurd, S.S.3
  • 33
    • 1842552109 scopus 로고    scopus 로고
    • Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper
    • Celli B.R., and MacNee W. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J 23 (2004) 932-946
    • (2004) Eur Respir J , vol.23 , pp. 932-946
    • Celli, B.R.1    MacNee, W.2
  • 34
    • 0026808393 scopus 로고
    • Corticosteroid-induced myopathy involving respiratory muscles in patients with chronic obstructive pulmonary disease or asthma
    • Decramer M., and Stas K.J. Corticosteroid-induced myopathy involving respiratory muscles in patients with chronic obstructive pulmonary disease or asthma. Am Rev Respir Dis 146 (1992) 800-802
    • (1992) Am Rev Respir Dis , vol.146 , pp. 800-802
    • Decramer, M.1    Stas, K.J.2
  • 35
    • 0028237807 scopus 로고
    • Corticosteroids contribute to muscle weakness in chronic airflow obstruction
    • Decramer M., Lacquet L.M., Fagard R., and Rogiers P. Corticosteroids contribute to muscle weakness in chronic airflow obstruction. Am J Respir Crit Care Med 150 (1994) 11-16
    • (1994) Am J Respir Crit Care Med , vol.150 , pp. 11-16
    • Decramer, M.1    Lacquet, L.M.2    Fagard, R.3    Rogiers, P.4
  • 37
    • 0029866161 scopus 로고    scopus 로고
    • Effects of long-term treatment with corticosteroids in COPD
    • Renkema T.E., Schouten J.P., Koeter G.H., and Postma D.S. Effects of long-term treatment with corticosteroids in COPD. Chest 109 (1996) 1156-1162
    • (1996) Chest , vol.109 , pp. 1156-1162
    • Renkema, T.E.1    Schouten, J.P.2    Koeter, G.H.3    Postma, D.S.4
  • 38
    • 32944482733 scopus 로고    scopus 로고
    • Oral corticosteroids for stable chronic obstructive pulmonary disease
    • (3):CD005374
    • Walters J.A., Walters E.H., and Wood-Baker R. Oral corticosteroids for stable chronic obstructive pulmonary disease. Cochrane Database Syst Rev (2005) (3):CD005374
    • (2005) Cochrane Database Syst Rev
    • Walters, J.A.1    Walters, E.H.2    Wood-Baker, R.3
  • 39
    • 0034727453 scopus 로고    scopus 로고
    • Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trial
    • Brightling C.E., Monteiro W., and Ward R. Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 356 (2000) 1480-1485
    • (2000) Lancet , vol.356 , pp. 1480-1485
    • Brightling, C.E.1    Monteiro, W.2    Ward, R.3
  • 40
    • 0032960818 scopus 로고    scopus 로고
    • The combination of ipratropium and albuterol optimizes pulmonary function reversibility testing in patients with COPD
    • Dorinsky P.M., Reisner C., Ferguson G.T., Menjoge S.S., Serby C.W., and Witek Jr. T.J. The combination of ipratropium and albuterol optimizes pulmonary function reversibility testing in patients with COPD. Chest 115 (1999) 966-971
    • (1999) Chest , vol.115 , pp. 966-971
    • Dorinsky, P.M.1    Reisner, C.2    Ferguson, G.T.3    Menjoge, S.S.4    Serby, C.W.5    Witek Jr., T.J.6
  • 42
    • 0025794113 scopus 로고
    • Effects of allergy and age on responses to salbutamol and ipratropium bromide in moderate asthma and chronic bronchitis
    • van Schayck C.P., Folgering H., Harbers H., Maas K.L., and van Weel C. Effects of allergy and age on responses to salbutamol and ipratropium bromide in moderate asthma and chronic bronchitis. Thorax 46 (1991) 355-359
    • (1991) Thorax , vol.46 , pp. 355-359
    • van Schayck, C.P.1    Folgering, H.2    Harbers, H.3    Maas, K.L.4    van Weel, C.5
  • 43
    • 33745030084 scopus 로고    scopus 로고
    • Ipratropium bromide versus short acting beta-2 agonists for stable chronic obstructive pulmonary disease
    • (2):CD001387
    • Appleton S., Jones T., Poole P., Pilotto L., Adams R., Lasserson T.J., et al. Ipratropium bromide versus short acting beta-2 agonists for stable chronic obstructive pulmonary disease. Cochrane Database Syst Rev (2006) (2):CD001387
    • (2006) Cochrane Database Syst Rev
    • Appleton, S.1    Jones, T.2    Poole, P.3    Pilotto, L.4    Adams, R.5    Lasserson, T.J.6
  • 44
    • 0033534194 scopus 로고    scopus 로고
    • Tiotropium (Spiriva): mechanistical considerations and clinical profile in obstructive lung disease
    • Disse B., Speck G.A., Rominger K.L., Witek Jr. T.J., and Hammer R. Tiotropium (Spiriva): mechanistical considerations and clinical profile in obstructive lung disease. Life Sci 64 (1999) 457-464
    • (1999) Life Sci , vol.64 , pp. 457-464
    • Disse, B.1    Speck, G.A.2    Rominger, K.L.3    Witek Jr., T.J.4    Hammer, R.5
  • 45
    • 0033994636 scopus 로고    scopus 로고
    • The pharmacological properties of tiotropium
    • 63S-66
    • Barnes P.J. The pharmacological properties of tiotropium. Chest 117 suppl (2000) 63S-66
    • (2000) Chest , vol.117 , Issue.SUPPL
    • Barnes, P.J.1
  • 47
    • 0036181956 scopus 로고    scopus 로고
    • A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease
    • Casaburi R., Mahler D.A., Jones P.W., Wanner A., San P.G., ZuWallack R.L., et al. A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease. Eur Respir J 19 (2002) 217-224
    • (2002) Eur Respir J , vol.19 , pp. 217-224
    • Casaburi, R.1    Mahler, D.A.2    Jones, P.W.3    Wanner, A.4    San, P.G.5    ZuWallack, R.L.6
  • 48
    • 2542603339 scopus 로고    scopus 로고
    • Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD
    • O'Donnell D.E., Fluge T., Gerken F., Hamilton A., Webb K., Aguilaniu B., et al. Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD. Eur Respir J 23 (2004) 832-840
    • (2004) Eur Respir J , vol.23 , pp. 832-840
    • O'Donnell, D.E.1    Fluge, T.2    Gerken, F.3    Hamilton, A.4    Webb, K.5    Aguilaniu, B.6
  • 49
    • 24944525709 scopus 로고    scopus 로고
    • Improvements in symptom-limited exercise performance over 8 h with once-daily tiotropium in patients with COPD
    • Maltais F., Hamilton A., Marciniuk D., Hernandez P., Sciurba F.C., Richter K., et al. Improvements in symptom-limited exercise performance over 8 h with once-daily tiotropium in patients with COPD. Chest 128 (2005) 1168-1178
    • (2005) Chest , vol.128 , pp. 1168-1178
    • Maltais, F.1    Hamilton, A.2    Marciniuk, D.3    Hernandez, P.4    Sciurba, F.C.5    Richter, K.6
  • 50
    • 0038366897 scopus 로고    scopus 로고
    • Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD
    • Brusasco V., Hodder R., Miravitlles M., Korducki L., Towse L., and Kesten S. Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD. Thorax 58 (2003) 399-404
    • (2003) Thorax , vol.58 , pp. 399-404
    • Brusasco, V.1    Hodder, R.2    Miravitlles, M.3    Korducki, L.4    Towse, L.5    Kesten, S.6
  • 51
    • 24644492301 scopus 로고    scopus 로고
    • Prevention of exacerbations of chronic obstructive pulmonary disease with tiotropium, a once-daily inhaled anticholinergic bronchodilator: a randomized trial
    • Niewoehner D.E., Rice K., Cote C., Paulson D., Cooper Jr. J.A., Korducki L., et al. Prevention of exacerbations of chronic obstructive pulmonary disease with tiotropium, a once-daily inhaled anticholinergic bronchodilator: a randomized trial. Ann Intern Med 143 (2005) 317-326
    • (2005) Ann Intern Med , vol.143 , pp. 317-326
    • Niewoehner, D.E.1    Rice, K.2    Cote, C.3    Paulson, D.4    Cooper Jr., J.A.5    Korducki, L.6
  • 52
    • 33750029372 scopus 로고    scopus 로고
    • Tiotropium for stable chronic obstructive pulmonary disease: a meta-analysis
    • Barr R.G., Bourbeau J., Camargo C.A., and Ram F.S. Tiotropium for stable chronic obstructive pulmonary disease: a meta-analysis. Thorax 61 (2006) 854-862
    • (2006) Thorax , vol.61 , pp. 854-862
    • Barr, R.G.1    Bourbeau, J.2    Camargo, C.A.3    Ram, F.S.4
  • 55
    • 0035938606 scopus 로고    scopus 로고
    • Long-Acting β2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma. A randomized controlled trial
    • Lazarus S.C., Boushey H.A., Fahy J.V., Chinchilli V.M., Lemanske R.F., Sorkness C.A., et al. Long-Acting β2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma. A randomized controlled trial. JAMA 285 (2001) 2583-2593
    • (2001) JAMA , vol.285 , pp. 2583-2593
    • Lazarus, S.C.1    Boushey, H.A.2    Fahy, J.V.3    Chinchilli, V.M.4    Lemanske, R.F.5    Sorkness, C.A.6
  • 56
    • 0036855114 scopus 로고    scopus 로고
    • Expert panel report: guidelines for the diagnosis and management of asthma update on selected topics-2002
    • National Asthma Education and Prevention Program
    • National Asthma Education and Prevention Program. Expert panel report: guidelines for the diagnosis and management of asthma update on selected topics-2002. J Allergy Clin Immunol 110 suppl (2002) S141-S219
    • (2002) J Allergy Clin Immunol , vol.110 , Issue.SUPPL
  • 57
    • 33144476873 scopus 로고    scopus 로고
    • The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol
    • Nelson H.S., Weiss S.T., Bleecker E.R., Yancey S.W., Dorinsky P.M., and Group S.S. The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest 129 (2006) 15-26
    • (2006) Chest , vol.129 , pp. 15-26
    • Nelson, H.S.1    Weiss, S.T.2    Bleecker, E.R.3    Yancey, S.W.4    Dorinsky, P.M.5    Group, S.S.6
  • 58
    • 79959344460 scopus 로고    scopus 로고
    • Expert panel report 3 (EPR3): guidelines for diagnosis and management of asthma-summary report
    • National Asthma Education and Prevention Program
    • National Asthma Education and Prevention Program. Expert panel report 3 (EPR3): guidelines for diagnosis and management of asthma-summary report. J Allergy Clin Immunol 120 suppl (2007) S94-S138
    • (2007) J Allergy Clin Immunol , vol.120 , Issue.SUPPL
  • 61
    • 40949119305 scopus 로고    scopus 로고
    • Combined corticosteroid and long-acting beta-agonist in one inhaler versus inhaled steroids for chronic obstructive pulmonary disease
    • (4):CD006826
    • Nannini L.J., Cates C.J., Lasserson T.J., and Poole P. Combined corticosteroid and long-acting beta-agonist in one inhaler versus inhaled steroids for chronic obstructive pulmonary disease. Cochrane Database Syst Rev (2007) (4):CD006826
    • (2007) Cochrane Database Syst Rev
    • Nannini, L.J.1    Cates, C.J.2    Lasserson, T.J.3    Poole, P.4
  • 63
    • 0003256789 scopus 로고    scopus 로고
    • Mucolytic agents for chronic bronchitis or chronic obstructive pulmonary disease
    • (3):CD001287
    • Poole P.J., and Black P.N. Mucolytic agents for chronic bronchitis or chronic obstructive pulmonary disease. Cochrane Database Syst Rev (2006) (3):CD001287
    • (2006) Cochrane Database Syst Rev
    • Poole, P.J.1    Black, P.N.2
  • 65
    • 0034023927 scopus 로고    scopus 로고
    • Efficacy of oral long-term N-acetylcysteine in bronchopulmonary disease: a meta-analysis of published double-blind placebo-controlled clinical trials
    • Grandjean E.M., Berthet P., Ruffman R., and Leuenberger P. Efficacy of oral long-term N-acetylcysteine in bronchopulmonary disease: a meta-analysis of published double-blind placebo-controlled clinical trials. Clin Ther 22 (2000) 209-221
    • (2000) Clin Ther , vol.22 , pp. 209-221
    • Grandjean, E.M.1    Berthet, P.2    Ruffman, R.3    Leuenberger, P.4
  • 66
    • 0033898870 scopus 로고    scopus 로고
    • The effect of oral N-acetylcysteine in chronic bronchitis: a quantitative systematic review
    • Stey C., Steurer J., Bachmann S., Medici T.C., and Tramer M.R. The effect of oral N-acetylcysteine in chronic bronchitis: a quantitative systematic review. Eur Respir J 16 (2000) 253-262
    • (2000) Eur Respir J , vol.16 , pp. 253-262
    • Stey, C.1    Steurer, J.2    Bachmann, S.3    Medici, T.C.4    Tramer, M.R.5
  • 67
    • 0035954121 scopus 로고    scopus 로고
    • Oral mucolytic drugs for exacerbations of chronic obstructive pulmonary disease: systematic review
    • Poole P.J., and Black P.N. Oral mucolytic drugs for exacerbations of chronic obstructive pulmonary disease: systematic review. BMJ 322 (2001) 1271-1274
    • (2001) BMJ , vol.322 , pp. 1271-1274
    • Poole, P.J.1    Black, P.N.2
  • 68
    • 20944433417 scopus 로고    scopus 로고
    • Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo controlled trial
    • Decramer M., Rutten-van Molken M., Dekhuijzen P.N.R., Troosters T., van Herwaarden C., Pellegrino R., et al. Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo controlled trial. Lancet 365 (2005) 1552-1560
    • (2005) Lancet , vol.365 , pp. 1552-1560
    • Decramer, M.1    Rutten-van Molken, M.2    Dekhuijzen, P.N.R.3    Troosters, T.4    van Herwaarden, C.5    Pellegrino, R.6
  • 69
    • 28244476906 scopus 로고    scopus 로고
    • Selective phosphodiesterase 4 inhibitors in the treatment of allergy and inflammation
    • Smith V.B., and Spina D. Selective phosphodiesterase 4 inhibitors in the treatment of allergy and inflammation. Curr Opin Investig Drugs 6 (2005) 1136-1141
    • (2005) Curr Opin Investig Drugs , vol.6 , pp. 1136-1141
    • Smith, V.B.1    Spina, D.2
  • 70
    • 36749063803 scopus 로고    scopus 로고
    • Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD
    • Grootendorst D.C., Gauw S.A., Verhoosel R.M., Sterk P.J., Hospers J.J., Bredenbroker D., et al. Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD. Thorax 62 (2007) 1081-1087
    • (2007) Thorax , vol.62 , pp. 1081-1087
    • Grootendorst, D.C.1    Gauw, S.A.2    Verhoosel, R.M.3    Sterk, P.J.4    Hospers, J.J.5    Bredenbroker, D.6
  • 71
    • 23744451716 scopus 로고    scopus 로고
    • Roflumilast-an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial
    • Rabe K.F., Bateman E.D., O'Donnell D., Witte S., Bredenbroker D., and Bethke T.D. Roflumilast-an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 366 (2005) 563-571
    • (2005) Lancet , vol.366 , pp. 563-571
    • Rabe, K.F.1    Bateman, E.D.2    O'Donnell, D.3    Witte, S.4    Bredenbroker, D.5    Bethke, T.D.6
  • 73
    • 69149098943 scopus 로고    scopus 로고
    • Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials
    • Fabbri L.M., Calverley P.M., Izquierdo-Alonso J.L., Bundschuh D.S., Brose M., Martinez F.J., et al. Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials. Lancet 374 (2009) 695-703
    • (2009) Lancet , vol.374 , pp. 695-703
    • Fabbri, L.M.1    Calverley, P.M.2    Izquierdo-Alonso, J.L.3    Bundschuh, D.S.4    Brose, M.5    Martinez, F.J.6
  • 74
    • 69149103642 scopus 로고    scopus 로고
    • Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials
    • Calverley P.M., Rabe K.F., Goehring U.M., Kristiansen S., Fabbri L.M., and Martinez F.J. Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials. Lancet 374 (2009) 685-694
    • (2009) Lancet , vol.374 , pp. 685-694
    • Calverley, P.M.1    Rabe, K.F.2    Goehring, U.M.3    Kristiansen, S.4    Fabbri, L.M.5    Martinez, F.J.6
  • 75
    • 0018885920 scopus 로고
    • Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: a clinical trial
    • Nocturnal Oxygen Therapy Trial Group
    • Nocturnal Oxygen Therapy Trial Group. Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: a clinical trial. Ann Intern Med 93 (1980) 391-398
    • (1980) Ann Intern Med , vol.93 , pp. 391-398
  • 76
    • 0019460452 scopus 로고
    • Long term domiciliary oxygen therapy in chronic hypoxic cor pulmonale complicating chronic bronchitis and emphysema. Report of the Medical Research Council Working Party
    • Long term domiciliary oxygen therapy in chronic hypoxic cor pulmonale complicating chronic bronchitis and emphysema. Report of the Medical Research Council Working Party. Lancet 1 (1981) 681-686
    • (1981) Lancet , vol.1 , pp. 681-686
  • 77
    • 0030774771 scopus 로고    scopus 로고
    • Effect of long-term oxygen therapy on survival in patients with chronic obstructive pulmonary disease with moderate hypoxaemia
    • Gorecka D., Gorzelak K., Sliwinski P., Tobiasz M., and Zielinski J. Effect of long-term oxygen therapy on survival in patients with chronic obstructive pulmonary disease with moderate hypoxaemia. Thorax 52 (1997) 674-679
    • (1997) Thorax , vol.52 , pp. 674-679
    • Gorecka, D.1    Gorzelak, K.2    Sliwinski, P.3    Tobiasz, M.4    Zielinski, J.5
  • 79
    • 0027962628 scopus 로고
    • Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The Lung Health Study
    • Anthonisen N.R., Connett J.E., Kiley J.P., Altose M.D., Bailey W.C., Buist A.S., et al. Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The Lung Health Study. JAMA 272 (1994) 1497-1505
    • (1994) JAMA , vol.272 , pp. 1497-1505
    • Anthonisen, N.R.1    Connett, J.E.2    Kiley, J.P.3    Altose, M.D.4    Bailey, W.C.5    Buist, A.S.6
  • 80
    • 13444250953 scopus 로고    scopus 로고
    • The effects of a smoking cessation intervention on 14.5-year mortality: a randomized clinical trial
    • Anthonisen N.R., Skeans M.A., Wise R.A., Manfreda J., Kanner R.E., and Connett J.E. The effects of a smoking cessation intervention on 14.5-year mortality: a randomized clinical trial. Ann Intern Med 142 (2005) 233-239
    • (2005) Ann Intern Med , vol.142 , pp. 233-239
    • Anthonisen, N.R.1    Skeans, M.A.2    Wise, R.A.3    Manfreda, J.4    Kanner, R.E.5    Connett, J.E.6
  • 81
    • 0022449190 scopus 로고
    • Independent influence of reversibility of air-flow obstruction and nonspecific hyperreactivity on the long-term course of lung function in chronic air-flow obstruction
    • Postma D.S., de Vries K., Koeter G.H., and Sluiter H.J. Independent influence of reversibility of air-flow obstruction and nonspecific hyperreactivity on the long-term course of lung function in chronic air-flow obstruction. Am Rev Respir Dis 134 (1986) 276-280
    • (1986) Am Rev Respir Dis , vol.134 , pp. 276-280
    • Postma, D.S.1    de Vries, K.2    Koeter, G.H.3    Sluiter, H.J.4
  • 83
    • 0022361308 scopus 로고
    • Assessment of ventilatory variables in survival prediction of patients with chronic airflow obstruction: the importance of reversibility
    • Postma D.S., Gimeno F., van der Weele L.T., and Sluiter H.J. Assessment of ventilatory variables in survival prediction of patients with chronic airflow obstruction: the importance of reversibility. Eur J Respir Dis 67 (1985) 360-368
    • (1985) Eur J Respir Dis , vol.67 , pp. 360-368
    • Postma, D.S.1    Gimeno, F.2    van der Weele, L.T.3    Sluiter, H.J.4
  • 84
    • 0034017303 scopus 로고    scopus 로고
    • Relationships of active smoking to asthma and asthma severity in the EGEA study. Epidemiological study on the Genetics and Environment of Asthma
    • Siroux V., Pin I., Oryszczyn M.P., Le Moual N., and Kauffmann F. Relationships of active smoking to asthma and asthma severity in the EGEA study. Epidemiological study on the Genetics and Environment of Asthma. Eur Respir J 15 (2000) 470-477
    • (2000) Eur Respir J , vol.15 , pp. 470-477
    • Siroux, V.1    Pin, I.2    Oryszczyn, M.P.3    Le Moual, N.4    Kauffmann, F.5
  • 85
    • 0032999901 scopus 로고    scopus 로고
    • Cigarette smoking and asthma symptom severity among adult asthmatics
    • Althuis M.D., Sexton M., and Prybylski D. Cigarette smoking and asthma symptom severity among adult asthmatics. J Asthma 36 (1999) 257-264
    • (1999) J Asthma , vol.36 , pp. 257-264
    • Althuis, M.D.1    Sexton, M.2    Prybylski, D.3
  • 86
    • 0037099152 scopus 로고    scopus 로고
    • Early life factors contribute to the decrease in lung function between ages 18 and 40: the Coronary Artery Risk Development in Young Adults study
    • Apostol G.G., Jacobs Jr. D.R., Tsai A.W., Crow R.S., Williams O.D., Townsend M.C., et al. Early life factors contribute to the decrease in lung function between ages 18 and 40: the Coronary Artery Risk Development in Young Adults study. Am J Respir Crit Care Med 166 (2002) 166-172
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 166-172
    • Apostol, G.G.1    Jacobs Jr., D.R.2    Tsai, A.W.3    Crow, R.S.4    Williams, O.D.5    Townsend, M.C.6
  • 87
    • 0032558685 scopus 로고    scopus 로고
    • A 15-year follow-up study of ventilatory function in adults with asthma
    • Lange P., Parner J., Vestbo J., Schnohr P., and Jensen G. A 15-year follow-up study of ventilatory function in adults with asthma. N Engl J Med 339 (1998) 1194-1200
    • (1998) N Engl J Med , vol.339 , pp. 1194-1200
    • Lange, P.1    Parner, J.2    Vestbo, J.3    Schnohr, P.4    Jensen, G.5
  • 88
    • 0026733395 scopus 로고
    • Long-term prognosis of near-fatal asthma. A 6-year follow-up study of 145 asthmatic patients who underwent mechanical ventilation for a near-fatal attack of asthma
    • Marquette C.H., Saulnier F., Leroy O., Wallaert B., Chopin C., Demarcq J.M., et al. Long-term prognosis of near-fatal asthma. A 6-year follow-up study of 145 asthmatic patients who underwent mechanical ventilation for a near-fatal attack of asthma. Am Rev Respir Dis 146 (1992) 76-81
    • (1992) Am Rev Respir Dis , vol.146 , pp. 76-81
    • Marquette, C.H.1    Saulnier, F.2    Leroy, O.3    Wallaert, B.4    Chopin, C.5    Demarcq, J.M.6
  • 90
    • 33745614361 scopus 로고    scopus 로고
    • Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs sustained-release bupropion and placebo for smoking cessation: a randomized controlled trial
    • Gonzales D., Rennard S.I., Nides M., Oncken C., Azoulay S., Billing C.B., et al. Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs sustained-release bupropion and placebo for smoking cessation: a randomized controlled trial. JAMA 296 (2006) 47-55
    • (2006) JAMA , vol.296 , pp. 47-55
    • Gonzales, D.1    Rennard, S.I.2    Nides, M.3    Oncken, C.4    Azoulay, S.5    Billing, C.B.6
  • 91
    • 33745611449 scopus 로고    scopus 로고
    • Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: a randomized controlled trial
    • Jorenby D.E., Hays J.T., Rigotti N.A., Azoulay S., Watsky E.J., Williams K.E., et al. Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: a randomized controlled trial. JAMA 296 (2006) 56-63
    • (2006) JAMA , vol.296 , pp. 56-63
    • Jorenby, D.E.1    Hays, J.T.2    Rigotti, N.A.3    Azoulay, S.4    Watsky, E.J.5    Williams, K.E.6
  • 92
    • 63249124498 scopus 로고    scopus 로고
    • Pulmonary rehabilitation for management of chronic obstructive pulmonary disease
    • Casaburi R., and ZuWallack R. Pulmonary rehabilitation for management of chronic obstructive pulmonary disease. N Engl J Med 360 (2009) 1329-1335
    • (2009) N Engl J Med , vol.360 , pp. 1329-1335
    • Casaburi, R.1    ZuWallack, R.2
  • 93
    • 34248371116 scopus 로고    scopus 로고
    • Pulmonary rehabilitation: joint ACCP/AACVPR evidence-based clinical practice guidelines
    • 4S-42
    • Ries A.L., Bauldoff G.S., Carlin B.W., Casaburi R., Emery C.F., Mahler D.A., et al. Pulmonary rehabilitation: joint ACCP/AACVPR evidence-based clinical practice guidelines. Chest 131 suppl (2007) 4S-42
    • (2007) Chest , vol.131 , Issue.SUPPL
    • Ries, A.L.1    Bauldoff, G.S.2    Carlin, B.W.3    Casaburi, R.4    Emery, C.F.5    Mahler, D.A.6
  • 96
    • 0028048820 scopus 로고
    • The efficacy and cost effectiveness of vaccination against influenza among elderly persons living in the community
    • Nichol K.L., Margolis K.L., Wuorenma J., and Von Sternberg T. The efficacy and cost effectiveness of vaccination against influenza among elderly persons living in the community. N Engl J Med 331 (1994) 778-784
    • (1994) N Engl J Med , vol.331 , pp. 778-784
    • Nichol, K.L.1    Margolis, K.L.2    Wuorenma, J.3    Von Sternberg, T.4
  • 98
    • 0035935983 scopus 로고    scopus 로고
    • The ALA Asthma Clinical Research Centers. The safety of inactivated influenza vaccine in adults and children with asthma
    • The ALA Asthma Clinical Research Centers. The safety of inactivated influenza vaccine in adults and children with asthma. N Engl J Med 345 (2001) 1529-1536
    • (2001) N Engl J Med , vol.345 , pp. 1529-1536
  • 103
    • 58649113855 scopus 로고    scopus 로고
    • Recommended adult immunization schedule-United States 2009
    • Centers for Disease Control and Prevention
    • Centers for Disease Control and Prevention. Recommended adult immunization schedule-United States 2009. MMWR 57 53 (2009)
    • (2009) MMWR , vol.57 , Issue.53
  • 104
    • 69949094422 scopus 로고    scopus 로고
    • Superior immune response to protein-conjugate versus free pneumococcal polysaccharide vaccine in chronic obstructive pulmonary disease
    • Dransfield M.T., Nahm M.H., Han M.K., Harnden S., Criner G.J., Martinez F.J., et al. Superior immune response to protein-conjugate versus free pneumococcal polysaccharide vaccine in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 180 (2009) 499-505
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 499-505
    • Dransfield, M.T.1    Nahm, M.H.2    Han, M.K.3    Harnden, S.4    Criner, G.J.5    Martinez, F.J.6


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