Recombinant human deoxyribonuclease for the treatment of acute asthma in children

Thorax

Volumn 63, Issue 2, 2008, Pages 141-146

  Boogaard, R ^a   Smit, F ^b   Schornagel, R ^c   Vaessen Verberne, A A P H ^d   Kouwenberg, J M ^e   Hekkelaan, M ^f   Hendriks, T ^g   Feith, S W W ^h   Hop, W C J ⁱ   De Jongste, J C ^a   Merkus, P J F M ^a,j  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^b Medisch Centrum Rijnmond Zuid   (Netherlands)

^c ALBERT SCHWEITZER HOSPITAL   (Netherlands)

^d AMPHIA HOSPITAL   (Netherlands)

^e JULIANA CHILDREN S HOSPITAL   (Netherlands)

^f Department of Pediatrics ^*  (Netherlands)

^g CATHARINA HOSPITAL   (Netherlands)

^h SINT FRANCISCUS GASTHUIS   (Netherlands)

ⁱ ERASMUS MEDICAL CENTER   (Netherlands)

^j RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BRONCHODILATING AGENT; PLACEBO; RECOMBINANT ENZYME; RECOMBINANT HUMAN DEOXYRIBONUCLEASE; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; ASTHMA; CHILD; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; EMERGENCY WARD; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NEBULIZATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ACUTE DISEASE; ADMINISTRATION, INHALATION; ADOLESCENT; ANALYSIS OF VARIANCE; ANTI-ASTHMATIC AGENTS; ASTHMA; CHILD; CHILD, PRESCHOOL; DEOXYRIBONUCLEASES; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; HOSPITALIZATION; HUMANS; MALE; NEBULIZERS AND VAPORIZERS; RECOMBINANT PROTEINS; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 39049144399     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.2007.081703     Document Type: Article

References (18)

1. Global Initiative for Asthma (GINA). Pocket guide for asthma management and prevention in children. 2006. www.ginasthma.org.
2. Wark PA, Gibson PG. Asthma exacerbations. 3: Pathogenesis. Thorax 2006;61:909-15.
3. Kuyper LM, Pare PD, Hogg JC, et al. Characterization of airway plugging in fatal asthma. Am J Med 2003;115:6-11.
4. Rogers DF. Airway mucus hypersecretion in asthma: an undervalued pathology? Curr Opin Pharmacol 2004;4:241-50.
5. Picot R, Das I, Reid L. Pus, deoxyribonucleic acid, and sputum viscosity. Thorax 1978;33:235-42.
6. Fahy JV, Kim KW, Liu J, et al. Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation. J Allergy Clin Immunol 1995;95:843-52.
7. Shak S, Capon DJ, Hellmiss R, et al. Recombinant human DNase I reduces the viscosity of cystic fibrosis sputum. Proc Natl Acad Sci USA 1990;87:9188-92.
8. Shah PL, Scott SF, Knight RA, et al. In vivo effects of recombinant human DNase I on sputum in patients with cystic fibrosis. Thorax 1996;51:119-25.
9. Fuchs HJ, Borowitz DS, Christiansen DH, et al. Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis. The Pulmozyme Study Group. N Engl J Med 1994;331:637-42.
10. Greally P. Human recombinant DNase for mucus plugging in status asthmaticus. Lancet 1995;346:1423-4.
11. Puterman AS, Weinberg EG. rhDNase in acute asthma. Pediatr Pulmonol 1997;23:316-7.
12. Durward A, Forte V, Shemie SD. Resolution of mucus plugging and atelectasis after intratracheal rhDNase therapy in a mechanically ventilated child with refractory status asthmaticus. Crit Care Med 2000;28:560-2.
13. Patel A, Harrison E, Durward A, et al. Intratracheal recombinant human deoxyribonuclease in acute life-threatening asthma refractory to conventional treatment. Br J Anaesth 2000;84:505-7.
14. Qureshi F, Pestian J, Davis P, et al. Effect of nebulized ipratropium on the hospitalization rates of children with asthma. N Engl J Med 1998;339:1030-5.
15. Fahy JV, Steiger DJ, Liu J, et al. Markers of mucus secretion and DNA levels in induced sputum from asthmatic and from healthy subjects. Am Rev Respir Dis 1993;147:1132-7.
16. Potter JL, Spector S, Matthews LW, et al. Studies on pulmonary secretions. 3. The nucleic acids in whole pulmonary secretions from patients with cystic fibrosis, bronchiectasis, and laryngectomy. Am Rev Respir Dis 1969;99:909-16.
17. Laube BL, Swift DL, Wagner HN Jr, et al. The effect of bronchial obstruction on central airway deposition of a saline aerosol in patients with asthma. Am Rev Respir Dis 1986;133:740-3.
18. Green JD. Pharmaco-toxicological expert report Pulmozyme rhDNase Genentech, Inc. Hum Exp Toxicol 1994;13(Suppl 1):S1-42.