Mutation in the heparan sulfate biosynthesis enzyme EXT1 influences growth factor signaling and fibroblast interactions with the extracellular matrix

Journal of Biological Chemistry

Volumn 284, Issue 50, 2009, Pages 34935-34943

  Österholm, Cecilia ^a   Barczyk, Malgorzata M ^a   Busse, Marta ^b   Grønning, Mona ^a   Reed, Rolf K ^a   Kusche Gullberg, Marion ^a  

^a UNIVERSITY OF BERGEN   (Norway)

^b THE FRANCIS CRICK INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHAIN ELONGATION; COLLAGEN I; CRITICAL DETERMINANT; EMBRYONIC FIBROBLASTS; EXTRACELLULAR MATRICES; EXTRACELLULAR MATRIX PROTEIN; FIBROBLAST GROWTH FACTOR; GENE TRAP; GLYCOSYL TRANSFERASE; GROWTH FACTOR; HEPARAN SULFATES; INTEGRINS; MOUSE EMBRYONIC FIBROBLASTS; MUTATION RESULTS; PLATELET-DERIVED GROWTH FACTORS; PROTEIN INTERACTION; SPECIFIC BINDING; WILD TYPES;

BINDING ENERGY; BINDING SITES; BIOACTIVITY; CELL CULTURE; CHAIN LENGTH; COLLAGEN; FIBROBLASTS; HYDRAULIC STRUCTURES; PEPTIDES; SIGNALING;

TISSUE;

COLLAGEN BINDING PROTEIN; COLLAGEN TYPE 1; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 10; FIBROBLAST GROWTH FACTOR 2; HEPARAN SULFATE; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE 3; PLATELET DERIVED GROWTH FACTOR BB; PROTEIN EXT1; SCLEROPROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL ADHESION; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FIBROBLAST; GENE MUTATION; LIGAND BINDING; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; CELL PROLIFERATION; COLLAGEN; ENZYME ACTIVATION; EXOSTOSES, MULTIPLE HEREDITARY; EXTRACELLULAR MATRIX; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; HEPARITIN SULFATE; HUMANS; INTEGRINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MUTATION; N-ACETYLGLUCOSAMINYLTRANSFERASES; SIGNAL TRANSDUCTION;

MUS;

EID: 71749083632     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.005264     Document Type: Article

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