Importance of membrane-bound catechol-O-methyltransferase in L-DOPA metabolism: A pharmacokinetic study in two types of Comt gene modified mice

British Journal of Pharmacology

Volumn 158, Issue 8, 2009, Pages 1884-1894

  Kaenmaki M ^a   Tammimaki A ^a   Garcia Horsman, J A ^a   Myohanen T ^a   Schendzielorz, N ^a   Karayiorgou, M ^b   Gogos, J A ^b   Mannisto P T ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b College of Physicians and Surgeons ^*  (United States)

Author keywords

COMT; COMT knock out; Enzyme activity; L DOPA; MB COMT; Pharmacokinetics; S COMT

Indexed keywords

3 O METHYLDOPA; CARBIDOPA; CATECHOL METHYLTRANSFERASE; DOPAMINE; LEVODOPA; METHYLTRANSFERASE; SOLUBLE CATECHOL O METHYLTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BRAIN; CELL MEMBRANE; CONTROLLED STUDY; DNA MODIFICATION; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG METABOLISM; ENZYME ACTIVITY; FEMALE; GENE DELETION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOHISTOCHEMISTRY; MALE; MAXIMUM PLASMA CONCENTRATION; METABOLITE; MOUSE; NONHUMAN; PHARMACOLOGICAL PARAMETERS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; STOMACH TUBE; WESTERN BLOTTING; WILD TYPE;

ADMINISTRATION, ORAL; ANIMALS; ANTIPARKINSON AGENTS; BLOTTING, WESTERN; CARBIDOPA; CATECHOL O-METHYLTRANSFERASE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; FEMALE; IMMUNOHISTOCHEMISTRY; ISOENZYMES; LEVODOPA; MALE; MICE; MICE, KNOCKOUT; SEX FACTORS; TIME FACTORS;

EID: 71649114185     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00494.x     Document Type: Article

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