Catechol-O-methyltransferase: Variation in enzyme activity and inhibition by entacapone and tolcapone

European Journal of Clinical Pharmacology

Volumn 54, Issue 3, 1998, Pages 215-219

  De Santi, C ^a   Giulianotti, P C ^a   Pietrabissa, A ^a   Mosca, F ^a   Pacifici, G M ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

Entacapone; Methyltransferase; Parkinson's disease; Tolcapone

Indexed keywords

CATECHOL METHYLTRANSFERASE; ENTACAPONE; PROTOCATECHUIC ACID; S ADENOSYLMETHIONINE; TOLCAPONE;

ADULT; AGED; ARTICLE; DUODENUM MUCOSA; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN TISSUE; KIDNEY CORTEX; LIVER; MALE; PARKINSON DISEASE; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; BENZOPHENONES; CATECHOL O-METHYLTRANSFERASE; CATECHOLS; DOSE-RESPONSE RELATIONSHIP, DRUG; DUODENUM; ENZYME INHIBITORS; FEMALE; HUMANS; KIDNEY; LIVER; LUNG; MALE; MIDDLE AGED; NITROPHENOLS; SEX FACTORS; TISSUE DISTRIBUTION;

EID: 0031807495     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002280050448     Document Type: Article

References (17)

1. Boudikova B, Szumlanski C, Maidak B, Weinshilboum RM (1990) Human liver catechol-O-methyltransferase pharmacogenetics. Clin Pharmacol Ther 48: 381-389
2. Da Prada M, Borgulya J, Napolitano A, Zurcher G (1994) Improved therapy of Parkinson's disease with tolcapone, a central and peripheral COMT inhibitor with an S-adenosyl-L-methionine sparing effect. J Clin Neuropharmacol 17 [Suppl 3]: S26 S37
3. Dingemanse J, Jorga K, Zurcher G, Schmitt M, Sedek G, Da Prada M, Van Brummelen P (1995) Pharmacokinetic-pharmacodynamic interaction between the COMT inhibitor tolcapone and single-dose levodopa. Br J Clin Pharmacol 40: 253-262
4. Dingemanse J, Jorga K, Zurcher G, Fotteler B, Sedek G, Nielsen T, Van Brummelen P (1996) Multiple-dose clinical pharmacology of the catechol-O-methyltransferase inhibitor tolcapone in elderly subjects. Eur J Clin Pharmacol 50: 47-55
5. Fahn S (1974) "On-off" phenomenon with levodopa therapy in parkinsonism. Neurology 24: 431-441
6. Ferroni MA, Marchi G, Sansone E, Romeo P, Giulianotti PC, Pietrabissa A, Mosca F, Pacifici GM (1996a) Variability in the rate of 6-mercaptopurine methylation in the erythrocytes, liver and kidney of an Italian population. Eur J Clin Pharmacol 51: 23-29
7. Ferroni MA, Giulianotti PC, Pietrabissa A, Mosca F, Gomeni R, Pacifici GM (1996b) Captopril methylation in the human liver and kidney: interindividual variability. Xenobiotica 26: 877-882
8. Kurth MC, Adler CH, Hilaire MS, Singer C, Waters C, Le-Witt P, Chernik DA, Dorflinger EE, Yoo K (1997) Tolcapone improves motor function and reduces levodopa requirement in patients with Parkinson's disease experiencing motor fluctuations. Neurology 48: 81-87
9. Lachman HM, Papolos DF, Saito T, Yu Y-M, Szumlanski CL, Weinshilboum RW (1996) Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 6: 243-250
10. Lowry OH, Rosebrough NJ, Farr A, and Randall RJ (1951) Protein measurement with Folin phenol reagent. J Biol Chem 193: 265-275
11. Luquin MR, Vaamonde J, Obeso JA (1987) Levodopa and 3-O-methyldopa plasma levels in parkinsonian patients with stable and fluctuating motor response. J Clin Neuropharmacol 12: 46-54
12. Myllyla VV, Sotaniemi KA, Illi A, Suominen K, Keranen T (1993) Effect of entacapone, a COMT inhibitor, on the pharmacokinetics of levodopa and on cardiovascular responses in patients with Parkinson's disease. Eur J Clin Pharmacol 45: 419-423
13. Pucifici GM, Donatelli P, Giuliani L (1992) Histamine N-methyltransferase: inhibition by drugs. Br J Clin Pharmacol 34: 322-327
14. Raymond FA, Weinshilboum RM (1975) Microassay of human erytrocyte catechol-O-methyltransferase: removal of calcium ion with chelating resin. Clin Chim Acta 58: 185-194
15. Routtinen HM, Rinne UK (1996a) A double-blind pharmacokinetic and clinical dose response study of entacapone as an adjuvant to levodopa therapy in advanced Parkinson's disease. J Clin Neuropharmacol 19: 283-296
16. Routtinen HM, Rinne UK (1996b) Entacapone prolongs levodopa response in one month doubled blind study in parkinsonian patients with levodopa-related fluctuations. J Neurol Neurosurg Psychiatry 60: 36-40
17. Weinshilboum RM, Raymond FA (1997) Inheritance of low erythrocyte catechol-O-methyltransferase activity in man. Am J Hum Genet 29: 125-135