A catechol-O-methyltransferase that is essential for auditory function in mice and humans

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 38, 2008, Pages 14609-14614

  Du, Xin ^a   Schwander, Martin ^a   Moresco, Eva Marie Y ^a   Viviani, Pia ^a   Haller, Claudia ^a   Hildebrand, Michael S ^b   Pak, Kwang ^c   Tarantino, Lisa ^d   Roberts, Amanda ^a   Richardson, Heather ^a   Koob, George ^a   Najmabadi, Hossein ^e   Ryan, Allen F ^c   Smith, Richard J H ^b   Müller, Ulrich ^a   Beutler, Bruce ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^e UNIVERSITY OF SOCIAL WELFARE AND REHABILITATION SCIENCES   (Iran)

Author keywords

Deafness; ENU; Genetics; Hearing; Positional cloning

Indexed keywords

CATECHOL METHYLTRANSFERASE; CATECHOL METHYLTRANSFERASE 2; CATECHOLAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATABOLISM; CONTROLLED STUDY; CORTI ORGAN; DNA DETERMINATION; ENZYME ACTIVITY; HAIR CELL; HEARING; HISTOPATHOLOGY; HUMAN; INNER EAR; MAJOR CLINICAL STUDY; MISSENSE MUTATION; MOUSE; NONHUMAN; NONSENSE MUTATION; NUCLEOTIDE SEQUENCE; ORTHOLOGY; PERCEPTION DEAFNESS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SCHIZOPHRENIA; VESTIBULAR FUNCTION;

AMINO ACID SEQUENCE; ANIMALS; CATECHOL O-METHYLTRANSFERASE; COCHLEA; DEAFNESS; GENE EXPRESSION REGULATION; HAIR CELLS, AUDITORY, INNER; HAIR CELLS, AUDITORY, OUTER; HEARING; HUMANS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; ORGAN OF CORTI; PEDIGREE; POINT MUTATION;

MURINAE; MUS;

EID: 55749087181     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0807219105     Document Type: Article

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