Pathway Reporter Assays Reveal Small Molecule Mechanisms of Action

Journal of Laboratory Automation

Volumn 14, Issue 6, 2009, Pages 374-382

  King, Frederick J ^a,b   Selinger, Douglas W ^a   Mapa, Felipa A ^a   Janes, Jeff ^b   Wu, Hua ^a   Smith, Timothy R ^b   Wang, Qing Yin ^c   Niyomrattanakitand, Pornwaratt ^c   Sipes, Daniel G ^b   Brinker, Achim ^b   Porter, Jeffrey A ^a   Myer, Vic E ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^c NOVARTIS INSTITUTE FOR TROPICAL DISEASES   (Singapore)

Author keywords

chemical genomics; high throughput screening; mechanism of action; reporter gene assay

Indexed keywords

BIOLOGICAL ACTIVITIES; BIOLOGICAL PROPERTIES; CELL-BASED; CELLULAR TARGETS; GENOMICS; HIGH THROUGHPUT SCREENING; MECHANISM OF ACTION; NATURAL PRODUCTS; PHENOTYPIC SCREENING; REFERENCE DATABASE; REPORTER ASSAY; REPORTER GENE ASSAY; REPORTER GENE ASSAYS; SMALL MOLECULES;

ASSAYS; THROUGHPUT;

LEAD COMPOUNDS;

DIHYDROOROTATE DEHYDROGENASE; FIREFLY LUCIFERASE;

ARTICLE; BIOASSAY; BIOLOGICAL ACTIVITY; CELL ACTIVITY; CELL VIABILITY; CONTROLLED STUDY; GENETIC DATABASE; HIGH THROUGHPUT SCREENING; LABORATORY AUTOMATION; MOLECULAR GENETICS; MOLECULAR WEIGHT; MOLECULE; PHENOTYPE; REPORTER GENE; REPORTER GENE ASSAY; TARGET CELL;

EID: 71649113938     PISSN: 22110682     EISSN: 15402452     Source Type: Journal    
DOI: 10.1016/j.jala.2009.08.001     Document Type: Article

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