Three novel single nucleotide polymorphisms of UGT1A9 in a Thai population

Drug Metabolism and Pharmacokinetics

Volumn 24, Issue 5, 2009, Pages 482-485

  Korprasertthaworn, Porntipa ^a   Udomuksorn, Wandee ^b   Yoovathaworn, Krongtong ^a  

^a Mahidol University   (Thailand)

^b PRINCE OF SONGKLA UNIVERSITY   (Thailand)

Author keywords

Nonsynonymous SNP; Novel SNPs; Thai; Udp glucuronosyltransferase; Ugt1a9

Indexed keywords

ADENINE; CYTIDINE; GLUCURONOSYLTRANSFERASE 1A9; GUANIDINE; THYMIDINE;

AMINO ACID SUBSTITUTION; ARTICLE; ASIAN; DNA SEQUENCE; EXON; GENE FREQUENCY; GENOTYPE; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; NUCLEIC ACID BASE SUBSTITUTION; NUCLEOTIDE SEQUENCE; POPULATION GENETICS; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; STOP CODON; THAI; THAILAND; TRANSLATION INITIATION;

EID: 71449126247     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.24.482     Document Type: Article

References (20)

1. Mackenzie, P. I., Owens, I. S., Burchell, B., Bock, K. W., Bairoch, A., Belanger, A., Fournel-Gigleux, S., Green, M., Hum, D. W., Iyanagi, T., Lancet, D., Louisot, P., Magdalou, J., Chowdhury, J. R., Ritter, J. K., Schachter, H., Tephly, T. R., Tipton, K. F. and Nebert, D. W.: The UDP-glycosyltransferase gene super-family: recommended nomenclature update based on evolutionary divergence. Pharmacogenetics, 7: 255-269 (1997)
2. Mackenzie, P. I., Bock, K. W., Burchell, B., Guillemette, C., Ikushiro, S., Iyanagi, T., Miners, J. O., Owens, I. S. and Nebert, D. W.: Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. Pharmacogenet. Genomics, 15: 677-685 (2005).
3. Gong, Q. H., Cho, J. W., Huang T., Potter, C., Gholami, N., Basu, N. K., Kubota, S., Carvalho, S., Pennington, M. W., Owens, I. S. and Popescu, N. C.: Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus. Pharmacogenetics, 11: 357-368 (2001)
4. Strassburg, C. P., Manns, M. P. and Tukey, R. H.: Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8. J. Biol. Chem., 273: 8719-8726 (1998).
5. Albert, C., Vallee, M., Beaudry, G., Belanger, A. and Hum, D. W.: The monkey and human uridine diphosphate-glucuronosyltransferase UGT1A9, expressed in steroid target tissues, are estrogen-conjugating enzymes. Endocrinology, 140: 3292-3302 (1999).
6. Findlay, K. A., Kaptein, E., Visser, T. J. and Burchell, B.: Characterization of the uridine diphosphate-glucuronosyltransferase-catalyzing thyroid hormone glucuronidation in man. J. Clin. Endocrinol. Metab., 85: 2879-2883 (2000).
7. King, C. D., Rios, G. R., Green, M. D. and Tephly, T. R.: UDPglucuronosyltransferases.Curr. Drug Metab., 1: 143-161 (2000).
8. Ramfárez, J., Iyer, L., Journault, K., Beálanger, P., Innocenti, F., Ratain, M. J. and Guillemette, C.: In vitro characterization of hepatic flavopiridol metabolism using human liver microsomes and recombinant UGT enzymes. Pharm. Res., 19: 588-594 (2002).
9. Gagne, J. F., Montminy, V., Belanger, P., Journault, K., Gaucher, G. and Guillemette, C.: Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38). Mol. Pharmacol., 62: 608-617 (2002).
10. Girard, H., Court, M. H., Bernard, O., Fortier, L. C., Villeneuve, L., Hao, Q., Greenblatt, D. J., von Moltke, L. L., Perussed, L. and Guillemette, C.: Identification of common polymorphisms in the promoter of the UGT1A9 gene: evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver. Pharmacogenetics, 14: 501-515 (2004).
11. Yamanaka, H., Nakajima, M., Katoh, M., Hara, Y., Tachibana, O., Yamashita, J., McLeod, H. L. and Yokoi, T.: A novel polymorphism in the promoter region of human UGT1A9 gene(UGT1A9*22) and its effects on the transcriptional activity. Pharmacogenetics, 14: 329-332 (2004).
12. Villeneuve, L., Girard, H., Fortier, L. C., Gagne, J. F. and Guillemette, C. Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs. J. Pharmacol. Exp. Ther., 307: 117-128 (2003).
13. Saeki, M., Saito, Y., Jinno, H., Sai, K., Komamura, K., Ueno, K., Kamakura, S., Kitakaze, M., Shirao, K., Minami, H., Ohtsu, A., Yoshida, T., Saijo, N., Ozawa, S. and Sawada, J.: Three novel single nucleotide polymorphisms in UGT1A9. Drug Metab. Pharmacokinet 18: 146-149 (2003).
14. Jinno, H., Saeki, M., Saito, Y., Tanaka-Kagawa, T., Hanioka, N., Sai, K., Kaniwa, N., Ando, M., Shirao, K., Minami, H., Ohtsu, A., Yoshida, T., Saijo, N., Ozawa, S. and Sawada, J.: Functional characterization of human UDP-glucuronosyltransferase 1A9 variant, D256N, found in Japanese cancer patients. J. Pharmacol. Exp. Ther., 306: 688-693 (2003).
15. Peamkrasatam, S., Sriwatanakul, K., Kiyotani, K., Fujieda, M., Yamazaki, H., Kamataki, T. and Yoovathaworn, K.: In vivo evaluation of coumarin and nicotine as probe drugs to predict the metabolic capacity of CYP2A6 due to genetic polymorphism in Thais. Drug Metab. Pharmacokinet., 21: 475-484 (2006).
16. Yueh, M. F., Nguyen, N., Famourzadeh, M., Strassburg, C. P., Oda, Y., Guengerich, F. P. and Tukey, R. H.: The contribution of UDP-glucuronosyltransferase 1A9 on CYP1A2-mediated genotoxicity by aromatic and heterocyclic amines. Carcinogenesis, 22: 943-950 (2001).
17. Carlini, L. E., Meropol, N. J., Bever, J., Andria, M. L., Hill, T., Gold, P., Rogatko, A., Wang, H. and Blanchard, R. L.: UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan. Clin. Cancer Res., 11: 1226-1236 (2005).
18. Han, J. Y., Lim, H. S., Shin, E. S., Yoo, Y. K., Park, Y. H., Lee, J. E., Jang, I. J., Lee, D. H. and Lee, J. S.: Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinotecan and cisplatin. J. Clin. Oncol., 24: 2237-2244 (2006).
19. Innocenti, F. and Ratain, M. J.: Pharmacogenetics of irinotecan: clinical perspectives on the utility of genotyping. Pharmacogenomics, 7: 1211-1221 (2006).
20. Thomas, S. S., Li, S. S., Lampe, J. W., Potter, J. D. and Bigler, J.: Genetic variability, haplotypes, and htSNPs for exons 1 at the human UGT1A locus. Hum. Mutat., 27: 717 (2006).