The X-ray structure of carboxypeptidase a inhibited by a thiirane mechanism-based ihibitor

Chemical Biology and Drug Design

Volumn 75, Issue 1, 2010, Pages 29-34

  Fernández, Daniel ^a   Testero, Sebastian ^b   Vendrell, Josep ^a   Avilés, Francesc X ^a   Mobashery, Shahriar ^b  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

M14 family of proteases; Mechanism based inactivation; Metallopeptidase; Thiirane; X ray crystallography

Indexed keywords

2 BENZYL 3,4 EPITHIOBUTANOIC ACID; BENZYL DERIVATIVE; BUTYRIC ACID DERIVATIVE; CARBOXYPEPTIDASE A; ESTER; ETHYLENE OXIDE DERIVATIVE; GLUTAMIC ACID; METALLOPROTEINASE INHIBITOR; THIIRANE; THIOL; UNCLASSIFIED DRUG; ZINC ION;

ARTICLE; COVALENT BOND; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME INHIBITION; MOLECULAR INTERACTION; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; BINDING SITES; CARBOXYPEPTIDASES A; CATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DRUG DESIGN; ENZYME INHIBITORS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; SULFIDES; THERMODYNAMICS; X-RAY DIFFRACTION; X-RAYS;

EID: 71449101270     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2009.00907.x     Document Type: Article

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