Haptoglobin polymorphism, iron metabolism and mortality in HIV infection

AIDS

Volumn 12, Issue 9, 1998, Pages 1027-1032

  Delanghe, Joris R ^a   Langlois, Michel R ^a   Boelaert, Johan R ^b   Van Acker, Jos ^a   Van Wanzeele, Filip ^a   Van Der Groen, Guido ^c   Hemmer, Robert ^d   Verhofstede, Chris ^a   De Buyzere, Marc ^a   De Bacquer, Dirk ^a   Arendt, Vic ^d   Plum, Jean ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b General Hospital St Jan   (Belgium)

^c INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^d Centre Hospitalier   (Luxembourg)

Author keywords

Ferritin; Haptoglobin; HIV; HIV 1 load; Iron; Oxidative stress; Vitamin C

Indexed keywords

ASCORBIC ACID; FERRITIN; HAPTOGLOBIN; IRON; TRANSFERRIN;

ADULT; ARTICLE; BELGIUM; CAUCASIAN; CONTROLLED STUDY; FEMALE; FERRITIN BLOOD LEVEL; GEL ELECTROPHORESIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IRON BLOOD LEVEL; IRON METABOLISM; LUXEMBOURG; MAJOR CLINICAL STUDY; MALE; MORTALITY; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSFERRIN BLOOD LEVEL; VITAMIN BLOOD LEVEL;

EID: 7144264400     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199809000-00010     Document Type: Article

References (38)

1. Mocroft A, Johnson MA, Phillips AN: Factors affecting survival in patients with the acquired immunodeficiency syndrome. AIDS 1996, 10:1057-1065.
2. Haynes BF, Pantaleo G, Fauci AS: Toward an understanding of the correlates of protective immunity to HIV infection. Science 1996, 271:324-328.
3. Fauci AS: Host factors and the pathogenesis of HIV-induced disease. Nature 1996, 384:529-533.
4. Langlois M, Delanghe J: Biological and clinical significance of haptoglobin polymorphism in humans. Clin Chem 1996, 42:1589-1600.
5. Kino J, Tsunoo H, Higa Y, Takami M: Hemoglobin-haptoglobin receptor in rat plasma membrane. J Biol Chem 1980, 255:9616-9620.
6. Gutteridge JMC: Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clin Chem 1995, 41:1819-1828.
7. Gutteridge JMC: The antioxidant activity of haptoglobin towards haemoglobin-stimulated lipid peroxidation. Biochem Biophys Acta 1987, 917:214-223.
8. Langlois M, Delanghe J, Philippé J, et al.: Distribution of lymphocyte subsets in bone marrow and peripheral blood is associated with haptoglobin type. Eur J Clin Chem Clin Biochem 1997, 35:199-205.
9. Sadrzadeh SMH, Eaton JW: Hemoglobin-mediated oxidant damage to the central nervous system requires endogenous ascorbate. J Clin Invest 1988, 82:1510-1515.
10. Gordeuk VR, McLaren G, Samowitz W: Etiologies, consequences, and treatment of iron overload. Crit Rev Clin Lab Sci 1994, 31:89-133.
11. Livrea MA, Tesoriere L, Pintaudi AM, et al.: Oxidative stress and antioxidant status in β-thalassemia major: iron overload and depletion of lipid-soluble antioxidants. Blood 1996, 88: 3608-3614.
12. Langlois M, Delanghe J, De Buyzere M, Bernard D, Ouyang J: Effect of haptoglobin on the metabolism of vitamin C. Am J Clin Nutr 1997, 66:606-610.
13. Boelaert JR: Iron and infection. Acta Clin Belg 1996, 51:213-221.
14. Boelaert JR, Weinberg GA, Weinberg ED: Altered iron metabolism in HIV-infection: mechanisms, possible consequences, and proposals for management. Infect Agents Dis 1996, 5:36-46.
15. Weinberg ED: Iron withholding: a defense against viral infections. Biometals 1996, 9:393-399.
16. Smithies O: Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. Biochem J 1955, 61:629-641.
17. Fink PC, Roemer M, Haeckel R, et al.: Measurement of proteins with the Behring nephelometer: a multicentre evaluation. J Clin Chem Clin Biochem 1989, 27:261-276.
18. Whicher JT, Ritchie RF, Johnson AM, et al.: A new international reference preparation for proteins in human serum (RPPHS 5). Clin Chem 1994, 40:934-938.
19. Beutler HO: L-Ascorbate and L-dehydroascorbate. In Methods of Enzymatic Analysis. Vol VI. 3rd Edn. Edited by Bergmeier HU. Weinheim: Verlag Chemie; 1984:376-385.
20. Afar B, Merill J, Clark EA: Detection of lymphocyte subsets using three color/single-laser flow cytometry and the fluorescent dye peridinin chlorophyll-alpha protein. J Clin Immunol 1941, 11:254-261.
21. Revets H, Marissens S, De Wit S, et al.: Comparative evaluation of NASBA HIV-1 RNA QT, Amplicor-HIV Monitor, and Quantiplex HIV RNA assay, three methods for quantification of human immunodeficiency virus type 1 RNA in plasma. J Clin Microbiol 1996, 34:1058-1064.
22. Verhofstede C, Reniers S, Van Wanzeele F, Plum J: Evaluation of proviral copy number and plasma RNA level as early indicators of progression in HIV-1 infection: correlation with virological and immunological markers of disease. AIDS 1994, 8:1421-1427.
23. 6/I. AIDS 1997, 11:55-57
24. Mellors JW, Rinaldo CR, Gupta P, White RM, Todd JA, Kingsley LA: Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science 1996, 272:1167-1170.
25. O'Brien WA, Hartigan PM, Martin D, et al.: Changes in plasma HIV-1 RNA and CD4 lymphocyte counts and the risk of progression to AIDS. N Engl J Med 1996, 334:426-431.
26. Grunfeld C, Pang M, Doerrler W, Shigenaga J, Jensen P, Feingold K: Lipids, lipoproteins, triglyceride clearance, and cytokines in human immunodeficiency virus infection and the acquired immunodeficiency syndrome. J Clin Endocrinol Metab 1992, 74:1045-1052.
27. Stadtman ER: Ascorbic acid and oxidative inactivation of proteins. Am J Clin Nutr 1991, 54:1125S-1128S.
28. Frei B, England L, Ames BN: Ascorbic acid is an outstanding anti-oxidant in human blood plasma. Proc Natl Acad Sci USA 1989, 86:6377-6381.
29. Herbert V, Shaw S, Jayatilleke E: Vitamin C-driven free radical generation from iron. J Nutr 1996, 126:1213S-1220S.
30. Boelaert JR, Piette J, Weinberg GA, Sappey C, Weinberg ED: Iron and oxidative stress as a mechanism for the enhanced production of human immunodeficiency virus by alveolar macrophages from otherwise healthy cigarette smokers. J Infect Dis 1996, 173:1045-1046.
31. Wong GHW, McHugh T, Weber R, Goeddel DV: Tumor necrosis factor a selectively sensitizes human immunodeficiency virus infected cells to heat and radiation. Proc Natl Acad Sci USA 1991, 88:4372-4376.
32. Schreck R, Pieber P, Bauerle PA: Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1. EMBO J 1991, 10:2247-2258.
33. Harakeh S, Jariwalla RJ, Pauling L: Suppression of human immunodeficiency virus replication by ascorbate in chronically and acutely infected cells. Proc Natl Acad Sci USA 1990, 87:7245-7249.
34. Harakeh S, Jariwalla RJ: Comparative study of the anti-HIV activities of ascorbate and thiol-containing reducing agents in chronically HIV-infected cells. Am J Clin Nutr 1991, 54:1231S-1235S.
35. Rivas CI, Vera JC, Guaiquil VH, et al.: Increased uptake and accumulation of vitamin C in human immunodeficiency virus 1-infected hematopoietic cell lines. J Biol Chem 1997, 272:5814-5820.
36. Sappey C, Boelaert JR, Legrand-Poels S, Forceille C, Favier A, Piette J: Iron chelation decreases NF-κB and HIV type 1 activation due to oxidative stress. AIDS Res Hum Retroviruses 1995, 11:1049-1061.
37. Herzenberg LA, Derosa SC, Dubs JG, et al.: Glutathione deficiency is associated with impaired survival in HIV disease. Proc Natl Acad Sci USA 1997, 94:1967-1972.
38. Boelaert JR, Gordeuk VR, Piette J, Weinberg GA: Conference report: International Conference on HIV and Iron. Trop Med Int Health 1997, 2:1102-1106.