Screening for variability in the ciliary neurotrophic factor (CNTF) gene: No evidence for association with human obesity

Experimental and Clinical Endocrinology and Diabetes

Volumn 106, Issue 2, 1998, Pages 108-112

  Munzberg H ^a   Tafel, J ^a   Busing B ^a   Hinney, A ^b   Ziegler, A ^b   Mayer, H ^c   Siegfried, W ^d   Matthaei, S ^a   Greten, H ^a   Hebebrand, J ^b   Hamann, A ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c Klinik Hochried   (Germany)

^d Adipositas Rehabilitationszentrum I   (Germany)

Author keywords

Ciliary neurotrophic factor; Genetics; Leptin; Mutation; Obesity

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; LEPTIN RECEPTOR; MESSENGER RNA;

ADOLESCENT; ADULT; ALLELE; ARTICLE; BINDING SITE; CONTROLLED STUDY; ENERGY BALANCE; FEMALE; GENE FREQUENCY; GENE MUTATION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SCREENING; GENETIC VARIABILITY; HOMOZYGOSITY; HUMAN; HUMAN CELL; INTRON; MAJOR CLINICAL STUDY; MALE; OBESITY; ONSET AGE; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SCHOOL CHILD; SIGNAL TRANSDUCTION; SINGLE STRAND CONFORMATION POLYMORPHISM;

EID: 7144261726     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0029-1211960     Document Type: Article

References (18)

1. Baumann H, Morella KK, White DW, Dembski M, Bailon PS, Kim H, Lai CF, Tartaglia LA: The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci USA 93: 8374-8378, 1996
2. Bouchard C: The causes of obesity: advances in molecular biology but stagnation on the genetic front. Diabetologia 39: 1532-1533, 1996
3. Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, Lakey ND, Culpepper J, Moore KJ, Breitbart RE, Duyk GM, Tepper RI, Morgenstern JP: Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor sene in db/db mice. Cell 84: 491-495, 1996
4. Gloaguen I, Costa P, Demartis A, Lazzaro D, Di Marco A, Graziani R, Paonessa G, Chen F, Rosenblum CI, Van der Ploeg LHT, Cortese R, Ciliberto G, Laufer R: Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance. Proc Natl Acad Sci USA 94: 6456-6461, 1997
5. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM: Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269: 543-546, 1995
6. Hamann A, Matthaei S: Regulation of energy balance by leptin. Exp Clin Endocrinol Diabetes 104: 293-300, 1996
7. Hebebrand J, Heseker H, Himmelmann GW, Schäfer H, Remschmidt H: Percentiles for the body mass index based on data of the German National Nutrition Survey and a review of relevant factors with an influence on body weight. Akt Ernähr Med 19: 259-265, 1994
8. Hinney A, Barth N, Ziegler A, von Prittwitz S, Hamann A, Hennighausen K, Lentes KU, Heils A, Rosenkranz K, Roth H, Coners H, Mayer H, Herzog W, Siegfried A, Lehmkuhl G, Poustka F, Schmidt MH, Schäfer H, Grzeschik KH, Pirke KM, Lesch KP, Remschmidt H, Hebebrand J: Serotonin transporter gene-linked polymorphic region: allele distributions in relationship to body weight and in anorexia nervosa. Life Sci 61: PL295-303, 1997
9. Ip NY, Yancopoulos GD: The neurotrophins and CNTF: two families of collaborative neurotrophic factors. Annu Rev Neurosci 19: 491-515, 1996
10. Lam A, Fuller F, Miller J, Kloss J, Manthorpe M, Varon S, Cordell B: Sequence and structural organization of the human gene encoding ciliary neurotrophic factor. Gene 102: 271-276, 1991
11. Masu Y, Wolf E, Holtmann B, Sendtner M, Brem G, Thoenen H: Disruption of the CNTF gene results in motor neuron degeneration. Nature 365: 27-32, 1993
12. Miller SA, Dykes DD, Polesky HF: A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16: 1215, 1988
13. Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, Sewter CP, Digby JE, Mohammed SN, Hurst JA, Cheetham CH, Earley AR, Barnett AH, Prins JB, O'Rahilly S: Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387: 903-908, 1997
14. Negro A, Tolosano E, Skaper SD, Martini I, Callegaro L, Silengo L, Fiorini F, Altruda F: Cloning and expression of human ciliary neurotrophic factor. Eur J Biochem 201: 289-294, 1991
15. Thome J, Durany N, Harsányi A, Foley P, Palomo A, Kornhuber J, Weijers HG, Baumer A, Rösler M, Cruz-Sánchez FF, Beckmann H, Riederer P: A null mutation in the CNTF gene and schizophrenic psychoses. Neuroreport 7: 1413-1416, 1996
16. Takahashi R, Yokoji H, Misawa H, Hayashi M, Hu J, Deguchi T: A null mutation in the human CNTF gene is not causally related to neurological diseases. Nat Genet 7: 79-84, 1994
17. Tartaglia LA: The leptin receptor. J. Biol Chem 272: 6093-6096, 1997
18. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432, 1994