Objective and subjective measures of the pharmacodynamic effects of Adderall® in the treatment of children with ADHD in a controlled laboratory classroom setting

Psychopharmacology Bulletin

Volumn 34, Issue 1, 1998, Pages 55-60

  Swanson, James ^a   Wigal, Sharon ^a   Greenhill, Larry ^b   Browne, Ronald ^c   Waslick, Bruce ^b   Lerner, Marc ^a   Williams, Lillie ^a   Flynn, Dan ^a   Agler, Dave ^a   Crowley, Kenton L ^a   Fineberg, Erick ^a   Regino, Roland ^a   Baren, Martin ^a   Cantwell, Dennis ^d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c Richwood Pharmaceuticals   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adderall ; Attention deficit hyperactivity disorder; Methylphenidate

Indexed keywords

AMPHETAMINE; METHYLPHENIDATE;

ADOLESCENT; ARTICLE; ATTENTION DEFICIT DISORDER; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SCHOOL CHILD; SCORING SYSTEM; TREATMENT OUTCOME;

ADOLESCENT; AMPHETAMINES; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CENTRAL NERVOUS SYSTEM STIMULANTS; CHILD; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; METHYLPHENIDATE;

EID: 7144250515     PISSN: 00485764     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. American Psychiatric Association. DSM-IV: Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: The Association, 1994.
2. Borcherding, BG; Keysor, CS; Cooper, TB; and Rapoport, JS. Differential effects of methylphenidate and dextroamphetamine on the motor activity level of hyperactive children. Neuropsychopharmacology 2:255-263, 1989.
3. Cantwell, DP, ed. The Hyperactive Child: Diagnosis, Management, and Current Research. New York: Spectrum Publications, 1975.
4. Elia, J; Borcherding, BG; Rapoport, JL; and Keysor, CS. Methylphenidate and dextroamphetamine treatment of hyperactivity: Are there true nonresponders? Psychiatry Res. 36:141-155, 1991.
5. Greenhill, LL, and Osman, BB, eds. Ritalin: Theory and Patient Management. New York: Mary Ann Liebert Publishers, 1991.
6. Greenhill, LL; Abikoff, HB; Arnold, LE; Cantwell, DP; Conners, CK; Elliott, G; Hechtman, L; Hinshaw, SP; Hoza, B; Jensen, PS; March, JS; Newcorn, J; Pelham, WE; Severe, JB; Swanson, JM; Vitiello, B; and Wells, K. Medication treatment strategies in the MTA study: Relevance to clinicians and researchers. J. Am. Acad. Child Adolesc. Psychiatry 35(10):1304-1313, 1996.
7. Holford, NH, and Sheiner, LB. Kinetics of pharmacologic response. Pharmacol. Ther. 16:143-166, 1982.
8. IDEA (Individuals With Disabilities Education Act). Public Law 94-142. The 1990 Reauthorization Bill of Public Law 94-142 (The Education for the Handicapped Act [EHA]), Reauthorized 1990.
9. McBurnett, K; Swanson, JM; Pfiffner, LJ; and Tamm, L. A measure of ADHD-related classroom impairment based on targets for behavioral intervention. J. Attention Disord. 2:69-76, 1997.
10. Peck, CC; Barr, WH; Benet, LZ; Collins, J; Desjardins, RE; Furst, DE; Harter, JG; Levy, G; Ludden, T; Rodman, JH; Sanathanan, L; Schentag, JJ; Shah, VP; Sheiner, LB; Skelly, JP; Stanski, DR; Temple, RJ; Viswanathan, CT; Weissinger, J; and Yacobi, A. Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development. Pharm. Res. 9(6):826-833, 1992.
11. Pelham, WE; Swanson, JM; Furman, MB; and Schwindt, H. Pemoline effects on children with ADHD: A time-response by dose-response analysis on classroom measures. J. Am. Acad Child Adolesc. Psychiatry 34(11):1504-1513, 1995.
12. Richters, JE; Arnold, LE; Jensen, PS; Abikoff, H; Conners, CK; Greenhill, LL; Hechtman, L; Hinshaw, SP; Pelham, WE; and Swanson, JM. NIMH Collaborative Multisite Multimodal Treatment Study of Children with ADHD: I. Background and rationale. J. Am. Acad. Child Adolesc. Psychiatry 34(8):987-1000, 1995.
13. Sergeant, J, and van der Meer, J. Additive factor method applied to psychopathology with special reference to childhood hyperactivity. Acta Psychol. (Amst.) 74:277-295, 1990.
14. Solanto, MV, and Conners, CK. A dose-response and time-action analysis of autonomic and behavioral effects of methylphenidate in attention deficit disorder with hyperactivity. Psychophysiology 19:658-667, 1982.
15. Swanson, JM. School-Based Assessments and Intervention for ADD Students. Irvine, CA: K.C. Publishing, 1992.
16. Swanson, JM; Kinsbourne, M; Roberts, W; and Zucker, K. A time-response analysis of the effect of stimulant medication on the learning ability of children referred for hyperactivity. Pediatrics 61:21-29, 1978.
17. Swanson, JM; McBurnett, K; Wigal, T; Pfiffner, L; Lerner, MA; Williams, L; Christian, DL; Tamm, L; Wilcutt, E; Crowley, K; Clevenger, W; Khouzam, N; Woo, C; Crinella, FM; and Fisher, TD. The effect of stimulant medication on ADD children: A review of reviews. Exceptional Children 60:154-162, 1993.
18. Swanson, J; Sergeant, J; Taylor, E; Sonuga-Barke, E; Jensen, PS; and Cantwell, D. Attention deficit hyperactivity disorder and hyperkinetic disorder. The Lancet 351:429-433, 1998a.
19. Swanson, JM; Wigal, SB; Greenhill, L; Browne, R; Waslick, B; Lerner, M; Williams, L; Flynn, D; Agler, D; Crowley, K; Fineberg, E; Baren, M; and Cantwell, D. Analog classroom assessment of Adderall® in children with ADHD. J. Am. Acad. Child Adolesc. Psychiatry 37:1-8, 1998b.
20. van der Meer, J; Wekking, E; and Sergeant, J. Sustained attention and pervasive hyperactivity. J. Child Psychol. Psychiatry 32:275-284, 1991.
21. Venitz, J. Pharmacokinetic-pharmacodynamic modeling of reversible drug effects. In: Derendorf, H, and Hochhaus, G, eds. Pharmacokinetic/Pharmacodynamic Correlation. Boca Raton, FL: CRC Press, 1995. pp. 1-34.
22. Wilens, TE, and Biederman, J. The stimulants. Psychiatr. Clin. North Am. 15:191-222, 1992.