Pharmacological profile of intrathecal fadolmidine, a α2- adrenoceptor agonist, in rodent models

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 380, Issue 6, 2009, Pages 539-550

  Leino, Tiina ^a   Viitamaa, Timo ^a   Haapalinna, Antti ^a   Lehtimäki, Jyrki ^a   Virtanen, Raimo ^a  

^a ORION CORPORATION   (Finland)

Author keywords

2 Adrenoceptor agonist; Analgesia; Cardiovascular; Gastrointestinal motility; Intrathecal; Sedation

Indexed keywords

ADRENERGIC RECEPTOR STIMULATING AGENT; CLONIDINE; DEXMEDETOMIDINE; FADOLMIDINE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; BODY TEMPERATURE; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; DRUG POTENCY; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL TRANSIT; HEART RATE; HYPOTHERMIA; MALE; MOTOR PERFORMANCE; MYDRIASIS; NONHUMAN; RAT; SEDATION;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; BEHAVIOR, ANIMAL; BODY TEMPERATURE; BRAIN; CLONIDINE; DEXMEDETOMIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GASTROINTESTINAL MOTILITY; IMIDAZOLES; INDANS; INJECTIONS, SPINAL; MALE; NOREPINEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-2; SEROTONIN;

EID: 71349083950     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-009-0460-6     Document Type: Article

References (41)

1. T Asai WW Mapleson I Power 1997 Differential effects of clonidine and dexmedetomidine on gastric emptying and gastrointestinal transit in the rat Br J Anaesth 78 301 307 1:CAS:528:DyaK2sXitFSgtrs%3D 9135310 (Pubitemid 27099922)
2. A Buvanendran JS Kroin 2007 Useful adjuvants for postoperative pain management Best Pract Res Clin Anaesthesiol 21 31 49 10.1016/j.bpa.2006.12.003 1:CAS:528:DC%2BD2sXjslGruro%3D 17489218 (Pubitemid 46504854)
3. Bylund DB, Blaxall HS, Murphy TJ, Simonneaux V (1991) Pharmacological evidence for alpha-2C and alpha-2D adrenergic receptor subtypes. In: Szabadi E, Bradshaw CM (eds) Advances in pharmacological sciences. Adrenoceptors: structure, mechanisms, function. Birkhäuser Verlag, Basle Boston Berlin, pp 27-36
4. MI Castro JC Eisenach 1989 Pharmacokinetics and dynamics of intravenous, intrathecal and epidural clonidine in sheep Anesthesiology 71 418 425 10.1097/00000542-198909000-00018 1:CAS:528:DyaL1MXls1Oiur4%3D 2774269
5. 2 agonist, is mediated in the locus coeruleus in rats Anesthesiology 76 948 952 10.1097/00000542-199206000-00013 1:CAS:528:DyaK38XksVSgsb8%3D 1350889
6. 2 adrenoceptor-mediated antinociception in sheep J Pharmacol Exp Ther 265 536 542 1:CAS:528:DyaK3sXks1ekuro%3D 8098758
7. 2-Adrenoceptors mediate clonidine-induced sedation in the rat Br J Pharmacol 67 133 141 1:CAS:528:DyaL3cXmvFCmtA%3D%3D 40643
8. 2-adrenergic agonists Anesthesiology 74 766 771 1:CAS:528:DyaK3MXisVSntrc%3D 1672580
9. JC Eisenach SL Shafer BA Bucklin C Jackson A Kallio 1994 Pharmacokinetics and pharmacodynamics of intraspinal dexmedetomidine in sheep Anesthesiology 80 1349 1359 1:CAS:528:DyaK2cXmt1Squr8%3D 7912045 (Pubitemid 24182609)
10. JC Eisenach M De Kock W Klimscha 1996 α2-Adrenergic agonists for regional anesthesia: a clinical review of clonidine (1984-1995) Anesthesiology 85 655 674 10.1097/00000542-199609000-00026 1:CAS:528:DyaK28XmslOitLw%3D 8853097
11. 2-adrenergic agonist, MPV-2426, in sheep Anesthesiology 91 1425 1436 10.1097/00000542-199911000-00036 1:CAS:528:DyaK1MXnsVGqtLw%3D 10551595 (Pubitemid 29506107)
12. L Ferder F Inserra F Medina 1987 Safety aspects of long-term antihypertensive therapy (10 years) with clonidine J Cardiovasc Pharmacol 10 Suppl 12 104 108 10.1097/00005344-198710012-00015
13. KS Filos LC Goudas O Patroni V Polyzou 1994 Hemodynamic and analgesic profile after intrathecal clonidine in humans Anesthesiology 81 591 601 10.1097/00000542-199409000-00011 1:STN:280:DyaK2cznvFCguw%3D%3D 8092504 (Pubitemid 24320667)
14. 2-adrenoceptor subtype binding, brain neurochemistry and behaviour in comparison with yohimbine Naunyn Schmiedebergs Arch Pharmacol 356 570 582 10.1007/PL00005092 1:CAS:528:DyaK2sXmvFeqtLY%3D 9402036 (Pubitemid 27478959)
15. 2-adrenoceptor antagonist atipamezole potentiates anti-Parkinsonian effects and can reduce the adverse cardiovascular effects of dopaminergic drugs in rats Naunyn Schmiedebergs Arch Pharmacol 368 342 351 10.1007/s00210-003-0827-z 1:CAS:528:DC%2BD3sXovFOit70%3D 14566451 (Pubitemid 37491493)
16. 2-adrenoceptors Pharmacol Biochem Behav 50 219 224 10.1016/0091-3057(94)00299-X 1:CAS:528:DyaK2MXjsVSgtLY%3D 7537885
17. G Horváth M Kovács M Szikszay G Benedek 1994 Mydriatic and antinociceptive effects of intrathecal dexmedetomidine in conscious rats Eur J Pharmacol 253 61 66 10.1016/0014-2999(94)90757-9 7912198
18. JH Kehne DW Gallager M Davis 1981 Strychnine: brainstem and spinal mediation of excitatory effects on acoustic startle Eur J Pharmacol 76 177 186 10.1016/0014-2999(81)90499-4 1:CAS:528:DyaL38XmtlygsQ%3D%3D 7333355 (Pubitemid 12250926)
19. 2- adrenoceptor drugs on the formalin test in rat: possible interactions J Psychopharmacol 20 67 74 10.1177/0269881105056996 1:CAS:528:DC%2BD28Xit1aluro%3D 16174681
20. JS Kroin RJ McCarthy RD Penn TR Lubenow AD Ivankovich 1996 Intrathecal clonidine and tizanidine in conscious dogs: comparison of analgesic and hemodynamic effects Anesth Analg 82 627 635 10.1097/00000539-199603000-00035 1:CAS:528:DyaK28XitlKgu7o%3D 8623973 (Pubitemid 26076571)
21. 2-adrenoceptor agonist with local mode of action Eur J Pharmacol 599 65 71 18930723
22. E MacDonald H Scheinin M Scheinin 1988 Behavioural and neurochemical effects of medetomidine, a novel veterinary sedative Eur J Pharmacol 158 119 127 10.1016/0014-2999(88)90260-9 1:CAS:528:DyaL1MXmvFeitA%3D%3D 2906007 (Pubitemid 19008810)
23. E MacDonald A Haapalinna R Virtanen R Lammintausta 1989 Effects of acute administration of medetomidine on the behaviour, temperature and turnover rates of brain biogenic amines in rodents and reversal of these effects by atipametzole Acta Vet Scand 85 77 81 1:STN:280:DyaL1MzptVejug%3D%3D
24. E MacDonald M Scheinin H Scheinin R Virtanen 1991 Comparison of the behavioral and neurochemical effects of the two optical enantiomers of medetomidine, a selective alpha-2-adrenoceptor agonist J Pharmacol Exp Ther 259 848 854 1:CAS:528:DyaK3MXmslSlsLg%3D 1682487
25. M Maze W Tranquilli 1991 Alpha-2 adrenoceptor agonist: defining the role in clinical anesthesia Anesthesiology 74 581 605 10.1097/00000542-199103000- 00029 1:CAS:528:DyaK3MXkt1Wns7k%3D 1672060
26. G Milligan P Svoboda CM Brown 1994 Why are there so many adrenoceptor subtypes? Biochem Pharmacol 48 1059 1071 10.1016/0006-2952(94)90141-4 1:CAS:528:DyaK2cXmt1aitrg%3D 7945399 (Pubitemid 24298355)
27. J Motsch E Graber K Lundwig 1990 Addition of clonidine enhances postoperative analgesia from epidural morphine: a double-blind study Anesthesiology 73 1067 1073 10.1097/00000542-199012000-00002 1:STN:280:DyaK3M%2FmtlGktQ%3D%3D 2248385
28. 2-noradrenergic receptors in the hypothalamus of the cat Pharmacol Biochem Behav 26 373 379 10.1016/0091-3057(87) 90132-8 1:CAS:528:DyaL2sXhsFSitrk%3D 3033698 (Pubitemid 17038122)
29. T Onttonen J Kalmari A Pertovaara 2000 Selective and segmentally restricted antinociception induced by MPV-2426, a novel alpha-2-adrenoceptor agonist, following intrathecal administration in the rat Acta Anaesthesiol Scand 44 1077 1082 10.1034/j.1399-6576.2000.440907.x 1:CAS:528:DC%2BD3cXntlSnsr0%3D 11028726 (Pubitemid 30739963)
30. 2-adrenoceptor agonist CNS Drug Rev 10 117 126 1:CAS:528:DC%2BD2cXmtlCntL4%3D 15179442
31. 2- adrenoceptor agonist, MPV-2426, following intrathecal application in neuropathic rats Anesthesiology 92 1082 1092 10.1097/00000542-200004000-00027 1:CAS:528:DC%2BD3cXivVeiurw%3D 10754629
32. K Pohjanoksa CC Jansson K Luomala A Marjamäki J-M Savola M Scheinin 1997 α2-Adrenoceptor regulation of adenylyl cyclase in CHO cells: dependence on receptor density, receptor subtype and current activity of adenylyl cyclase Eur J Pharmacol 335 53 63 10.1016/S0014-2999(97)01154-0 1:CAS:528:DyaK2sXmtFKns7s%3D 9371546 (Pubitemid 27450469)
33. 2-adrenoceptor agonists on gastrointestinal transit during croton oil-induced intestinal inflammation Br J Pharmacol 119 1649 1655 1:CAS:528:DyaK2sXktlWmsQ%3D%3D 8982514
34. 2- adrenoreceptors J Auton Pharmacol 5 275 284
35. J Savolainen R Niemi A Mäntylä J Huuskonen T Järvinen 2005 Fadolmidine-induced ocular hypotension in normotensive rabbits J Pharm Pharmacol 57 191 195 10.1211/0022357055308 1:CAS:528:DC%2BD2MXht1elsrY%3D 15720782 (Pubitemid 40129086)
36. 2-adrenoceptor agonist: a review of its pharmacodynamic effects Prog Neuro-Psychopharmacol Biol Psychiat 13 635 651 10.1016/0278-5846(89)90051-1 1:CAS:528:DyaL1MXls1Kltr4%3D
37. 2- adrenoceptors J Psychopharmacol 10 6 18 1:CAS:528:DyaK2sXhtlWktLs%3D
38. 2-adrenergic agonist compared with dexmedetomidine in different pain models in the rat Anesthesiology 93 473 481 10.1097/00000542- 200008000-00027 1:CAS:528:DC%2BD3cXlvFelu7s%3D 10910498
39. M Xu H Wei VK Kontinen E Kalso A Pertovaara 2000 The dissociation of sedative from spinal antinociceptive effects following administration of a novel alpha-2-adrenoceptor agonist, MPV-2426, in the locus coeruleus in the rat Acta Anaesthesiol Scand 44 648 655 10.1034/j.1399-6576.2000.440604.x 1:CAS:528:DC%2BD3cXlvFGnurg%3D 10903011 (Pubitemid 30413410)
40. TL Yaksh 1985 Pharmacology of spinal adrenergic system which modulate spinal nociceptive processing Pharmacol Biochem Behav 22 845 858 10.1016/0091-3057(85)90537-4 1:CAS:528:DyaL2MXksVOltL8%3D 2861606 (Pubitemid 15120533)
41. TL Yaksh TA Rudy 1976 Chronic catheterization of the spinal subarachnoid space Physiol Behav 17 1031 1036 10.1016/0031-9384(76)90029-9 1:STN:280:DC%2BD3srpsFynsA%3D%3D 14677603 (Pubitemid 8063691)