Whole genome association study in a homogenous population in Shandong peninsula of China reveals JARID2 as a susceptibility gene for schizophrenia

Journal of Biomedicine and Biotechnology

Volumn 2009, Issue , 2009, Pages

  Chen, Gang ^a   Liu, Yang ^a   Norton, Nadine ^b   Liu, Wenmin ^a   Zhu, Haining ^a   Zhou, Peng ^a   Luan, Meng ^a   Yang, Shulin ^a   Chen, Xing ^a   Carroll, Liam ^b   Williams, Nigel M ^b   O'Donovan, Michael C ^b   Kirov, George ^b   Owen, Michael J ^b  

^a SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY   (China)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; CARRIER PROTEIN; DTNBP1 PROTEIN, HUMAN; MICROSATELLITE DNA; NERVE PROTEIN;

ADULT; ALLELE; ARTICLE; CHINA; CONTROLLED STUDY; DINUCLEOTIDE REPEAT; DNTBP1 GENE; FEMALE; GENE; GENE FREQUENCY; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN GENOME; JARID2 GENE; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE MARKER; NUCLEOTIDE SEQUENCE; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; CASE CONTROL STUDY; GENE LINKAGE DISEQUILIBRIUM; GENETIC PREDISPOSITION; GENETICS; METHODOLOGY; POLYMERASE CHAIN REACTION;

ADULT; CARRIER PROTEINS; CASE-CONTROL STUDIES; CHINA; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOME, HUMAN; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MICROSATELLITE REPEATS; NERVE TISSUE PROTEINS; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; SCHIZOPHRENIA;

EID: 71149090779     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2009/536918     Document Type: Article

References (49)

1. Gottesman II, Schizophrenia Genesis: The Origins of Madness 1991 New York, NY, USA W. H. Freeman
2. Owen M. J., Genomic approaches to schizophrenia Clinical Therapeutics 2005 27 supplement 1 S2 S7
3. Kirov G., ODonovan M. C., Owen M. J., Finding schizophrenia genes The Journal of Clinical Investigation 2005 115 6 1440 1448
4. Owen M. J., Craddock N., ODonovan M. C., Schizophrenia: genes at last? Trends in Genetics 2005 21 9 518 525
5. Detera-Wadleigh S. D., McMahon F. J., G72/G30 in schizophrenia and bipolar disorder: review and meta-analysis Biological Psychiatry 2006 60 2 106 114
6. Bray N. J., Preece A., Williams N. M., Haplotypes at the dystrobrevin binding protein 1 (DTNBP1) gene locus mediate risk for schizophrenia through reduced DTNBP1 expression Human Molecular Genetics 2005 14 14 1947 1954
7. Hall D., Gogos J. A., Karayiorgou M., The contribution of three strong candidate schizophrenia susceptibility genes in demographically distinct populations Genes, Brain and Behavior 2004 3 4 240 248
8. Law A. J., Lipska B. K., Weickert C. S., Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5′ SNPs associated with the disease Proceedings of the National Academy of Sciences of the United States of America 2006 103 17 6747 6752
9. Levitt P., Ebert P., Mirnics K., Nimgaonkar V. L., Lewis D. A., Making the case for a candidate vulnerability gene in schizophrenia: convergent evidence for regulator of G-protein signaling 4 (RGS4) Biological Psychiatry 2006 60 6 534 537
10. Klein R. J., Zeiss C., Chew E. Y., Complement factor H polymorphism in age-related macular degeneration Science 2005 308 5720 385 389
11. Marx J., Gene offers insight into macular degeneration Science 2006 314 5798 405
12. Pennisi E., New gene found for inherited macular degeneration Science 1998 281 5373 31
13. Saxena R., Voight B. F., Lyssenko V., Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels Science 2007 316 5829 1331 1336
14. Thomson W., Barton A., Ke X., Rheumatoid arthritis association at 6q23 Nature Genetics 2007 39 12 1431 1433
15. Yang Z., Camp N. J., Sun H., A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration Science 2006 314 5801 992 993
16. Zeggini E., Weedon M. N., Lindgren C. M., Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes Science 2007 316 5829 1336 1341
17. Kirov G., Nikolov I., Georgieva L., Moskvina V., Owen M. J., ODonovan M., Pooled DNA genotyping on affymetrix SNP genotyping arrays BMC Genomics 2006 7 1, article 27
18. Tamiya G., Shinya M., Imanishi T., Whole genome association study of rheumatoid arthritis using 27 039 microsatellites Human Molecular Genetics 2005 14 16 2305 2321
19. Hstbacka J., de la Chapelle A., Kaitila I., Sistonen P., Weaver A., Lander E., Linkage disequilibrium mapping in isolated founder populations: diastrophic dysplasia in Finland Nature Genetics 1992 2 3 204 211
20. APA, Diagnostic and Statistical Manual of Mental Disorders DSM-IV-TR 1994 4th Washington, DC, USA American Psychiatric Association
21. Barrett J. C., Fry B., Maller J., Daly M. J., Haploview: analysis and visualization of LD and haplotype maps Bioinformatics 2005 21 2 263 265
22. Hawkins J. R., Khripin Y., Valdes A. M., Weaver T. A., Miniaturized sealed-tube allele-specific PCR Human Mutation 2002 19 5 543 553
23. Myakishev M. V., Khripin Y., Hu S., Hamer D. H., High-throughput SNP genotyping by allele-specific PCR with universal energy-transfer-labeled primers Genome Research 2001 11 1 163 169
24. Sham P. C., Curtis D., Monte Carlo tests for associations between disease and alleles at highly polymorphic loci Annals of Human Genetics 1995 59 1 97 105
25. Purcell S., Neale B., Todd-Brown K., PLINK: a tool set for whole-genome association and population-based linkage analyses American Journal of Human Genetics 2007 81 3 559 575
26. Dudbridge F., Pedigree disequilibrium tests for multilocus haplotypes Genetic Epidemiology 2003 25 2 115 121
27. Dawson E., Abecasis G. R., Bumpstead S., A first-generation linkage disequilibrium map of human chromosome 22 Nature 2002 418 6897 544 548
28. Venken T., Del-Favero J., Chasing genes for mood disorders and schizophrenia in genetically isolated populations Human Mutation 2007 28 12 1156 1170
29. Stefansson H., Sigurdsson E., Steinthorsdottir V., Neuregulin 1 and susceptibility to schizophrenia American Journal of Human Genetics 2002 71 4 877 892
30. Chumakov I., Blumenfeld M., Guerassimenko O., Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia Proceedings of the National Academy of Sciences of the United States of America 2002 99 21 13675 13680
31. Pedrosa E., Ye K., Nolan K. A., Positive association of schizophrenia to JARID2 gene American Journal of Medical Genetics B 2007 144 1 45 51
32. Straub R. E., Jiang Y., MacLean C. J., Genetic variation in the 6p22.3 Gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia American Journal of Human Genetics 2002 71 2 337 348
33. DeRosse P., Funke B., Burdick K. E., Dysbindin genotype and negative symptoms in schizophrenia American Journal of Psychiatry 2006 163 3 532 534 (Pubitemid 44469399)
34. Funke B., Finn C. T., Plocik A. M., Association of the DTNBP1 locus with schizophrenia in a U.S. population American Journal of Human Genetics 2004 75 5 891 898
35. Kirov G., Ivanov D., Williams N. M., Strong evidence for association between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia in 488 parent-offspring trios from Bulgaria Biological Psychiatry 2004 55 10 971 975
36. Kohn Y., Danilovich E., Filon D., Linkage disequlibrium in the DTNBP1 (dysbindin) gene region and on chromosome 1p36 among psychotic patients from a genetic isolate in Israel: findings from identity by descent haplotype sharing analysis American Journal of Medical Genetics B 2004 128 1 65 70
37. Li T., Zhang F., Liu X., Identifying potential risk haplotypes for schizophrenia at the DTNBP1 locus in Han Chinese and Scottish populations Molecular Psychiatry 2005 10 11 1037 1044
38. Numakawa T., Yagasaki Y., Ishimoto T., Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia Human Molecular Genetics 2004 13 21 2699 2708
39. Schwab S. G., Knapp M., Mondabon S., Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families American Journal of Human Genetics 2003 72 1 185 190
40. Van Den Bogaert A., Schumacher J., Schulze T. G., The DTNBP1 (dysbindin) gene contributes to schizophrenia, depending on family history of the disease American Journal of Human Genetics 2003 73 6 1438 1443
41. Williams N. M., Preece A., Morris D. W., Identification in 2 independent samples of a novel schizophrenia risk haplotype of the dystrobrevin binding protein gene (DTNBP1) Archives of General Psychiatry 2004 61 4 336 344
42. Weickert C. S., Straub R. E., McClintock B. W., Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain Archives of General Psychiatry 2004 61 6 544 555
43. Datta S. R., McQuillin A., Puri V., Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia Behavioral and Brain Functions 2007 3 1, article 50
44. Joo E.-J., Lee K.-Y., Jeong S. H., Ahn Y.-M., Koo Y. J., Kim Y. S., The dysbindin gene (DTNBP1) and schizophrenia: no support for an association in the Korean population Neuroscience Letters 2006 407 2 101 106
45. Liu C.-M., Liu Y.-L., Fann C. S.-J., No association evidence between schizophrenia and dystrobrevin-binding protein 1 (DTNBP1) in Taiwanese families Schizophrenia Research 2007 93 13 391 398
46. Morris D. W., McGhee K. A., Schwaiger S., No evidence for association of the dysbindin gene [DTNBP1] with schizophrenia in an Irish population-based study Schizophrenia Research 2003 60 2-3 167 172
47. Mutsuddi M., Morris D. W., Waggoner S. G., Daly M. J., Scolnick E. M., Sklar P., Analysis of high-resolution HapMap of DTNBP1 (dysbindin) suggests no consistency between reported common variant associations and schizophrenia American Journal of Human Genetics 2006 79 5 903 909
48. Turunen J. A., Peltonen J. O., Pietilinen O. P. H., The role of DTNBP1, NRG1, and AKT1 in the genetics of schizophrenia in Finland Schizophrenia Research 2007 91 13 27 36
49. Tang J. X., Zhou J., Fan J. B., Family-based association study of DTNBP1 in 6p22.3 and schizophrenia Molecular Psychiatry 2003 8 8 717 718