Evaluation of side effects through selective ablation of the mu opioid receptor expressing descending nociceptive facilitatory neurons in the rostral ventromedial medulla with dermorphin-saporin

NeuroToxicology

Volumn 30, Issue 6, 2009, Pages 1096-1106

  Cao, Fei ^a   Chen, Sha Sha ^a   Yan, Xiao Feng ^a   Xiao, Xing Peng ^a   Liu, Xi Jiang ^a   Yang, Shao Bing ^a   Xu, Ai Jun ^a   Gao, Feng ^a   Yang, Hui ^a   Chen, Zhi Jun ^a   Tian, Yu Ke ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Dermorphin; Descending facilitation; Opioid receptor; Rostral ventromedial medulla; Saporin

Indexed keywords

CYTOKINE; DERMORPHIN; INTERLEUKIN 1BETA; MU OPIATE RECEPTOR; SAPORIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN CELL; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EXPERIMENTAL TEST; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; INTRACTABLE PAIN; MALE; MEDULLA OBLONGATA; MICROINJECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR BLOCKING; TOXICITY TESTING; TRANSTHORACIC ECHOCARDIOGRAPHY;

ANALGESICS, OPIOID; ANIMALS; ANTIGENS, CD11B; DRINKING; EATING; ECHOCARDIOGRAPHY; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; HYPERALGESIA; IMMUNOTOXINS; INTERLEUKIN-1BETA; MALE; MEDULLA OBLONGATA; MICROINJECTIONS; MOTOR ACTIVITY; NEURONS; OPIOID PEPTIDES; PAIN MEASUREMENT; PAIN THRESHOLD; RATS; RATS, WISTAR; RECEPTORS, OPIOID, MU; RIBOSOME INACTIVATING PROTEINS, TYPE 1; TUMOR NECROSIS FACTOR-ALPHA;

RATTUS; RODENTIA;

EID: 71049152099     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2009.06.004     Document Type: Article

References (52)

1. Bee L.A., and Dickenson A.H. Rostral ventromedial medulla control of spinal sensory processing in normal and pathophysiological states. Neuroscience 147 3 (2007) 786-793
2. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72 (1976) 248-254
3. Burgess S.E., Gardell L.R., Ossipov M.H., Malan Jr. T.P., Vanderah T.W., Lai J., and Porreca F. Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain. J Neurosci 22 12 (2002) 5129-5136
4. Chaplan S.R., Bach F.W., Pogrel J.W., Chung J.M., and Yaksh T.L. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 53 1 (1994) 55-63
5. Colburn R.W., DeLeo J.A., Rickman A.J., Yeager M.P., Kwon P., and Hickey W.F. Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the rat. J Neuroimmunol 79 2 (1997) 163-175
6. Dampney R.A., Horiuchi J., Tagawa T., Fontes M.A., Potts P.D., and Polson J.W. Medullary and supramedullary mechanisms regulating sympathetic vasomotor tone. Acta Physiol Scand 177 3 (2003) 209-218
7. DeLeo J.A., and Yezierski R.P. The role of neuroinflammation and neuroimmune activation in persistent pain. Pain 90 1-2 (2001) 1-6
8. Dixon W.J. Efficient analysis of experimental observations. Annu Rev Pharmacol Toxicol 20 (1980) 441-462
9. Gardell L.R., Vanderah T.W., Gardell S.E., Wang R., Ossipov M.H., Lai J., and Porreca F. Enhanced evoked excitatory transmitter release in experimental neuropathy requires descending facilitation. J Neurosci 23 23 (2003) 8370-8379
10. Gearhart D.A., Middlemore M.L., and Terry A.V. ELISA methods to measure cholinergic markers and nerve growth factor receptors in cortex, hippocampus, prefrontal cortex, and basal forebrain from rat brain. J Neurosci Methods 150 2 (2006) 159-173
11. Gebhart G.F. Descending modulation of pain. Neurosci Biobehav Rev 27 8 (2004) 729-737
12. Gordon D.B., and Love G. Pharmacologic management of neuropathic pain. Pain Manag Nurs 5 4 Suppl 1 (2004) 19-33
13. Guastella V., Mick G., and Laurent B. Non pharmacologic treatment of neuropathic pain. Presse Med 37 2 Pt 2 (2008) 354-357
14. Hagar J.M., Matthews R., and Kloner R.A. Quantitative two-dimensional echocardiographic assessment of regional wall motion during transient ischemia and reperfusion in the rat. J Am Soc Echocardiogr 8 2 (1995) 162-174
15. Hanisch U.K., and Kettenmann H. Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nature Neurosci 10 11 (2007) 1387-1394
16. Hargreaves K., Dubner R., Brown F., Flores C., and Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32 1 (1988) 77-88
17. Hoit B.D., Castro C., Bultron G., Knight S., and Matlib M.A. Noninvasive evaluation of cardiac dysfunction by echocardiography in streptozotocin-induced diabetic rats. J Card Fail 5 4 (1999) 324-333
18. Hunter C.L., Quintero E.M., Gilstrap L., Bhat N.R., and Granholm A.C. Minocycline protects basal forebrain cholinergic neurons from mu p75-saporin immunotoxic lesioning. Eur J Neurosci 19 12 (2004) 3305-3316
19. Kalra A., Urban M.O., and Sluka K.A. Blockade of opioid receptors in rostral ventral medulla prevents antihyperalgesia produced by transcutaneous electrical nerve stimulation (TENS). J Pharmacol Exp Therap 298 1 (2001) 257-263
20. Kanpolat Y. Percutaneous destructive pain procedures on the upper spinal cord and brain stem in cancer pain: CT-guided techniques, indications and results. Adv Tech Stand Neurosurg 32 (2007) 147-173
21. Kim W.G., Mohney R.P., Wilson B., Jeohn G.H., Liu B., and Hong J.S. Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia. J Neurosci 20 16 (2000) 6309-6316
22. Kline RHt, and Wiley R.G. Spinal mu-opioid receptor-expressing dorsal horn neurons: role in nociception and morphine antinociception. J Neurosci 28 4 (2008) 904-913
23. Kwok K.H., Law K.B., Wong R.N., and Yung K.K. Immunolesioning of nerve growth factor p75 receptor-containing neurons in the rat brain by a novel immunotoxin: anti-p75-anti-mouse IgG-trichosanthin conjugates. Brain Res 846 2 (1999) 154-163
24. Litwin S.E., Katz S.E., Weinberg E.O., Lorell B.H., Aurigemma G.P., and Douglas P.S. Serial echocardiographic-Doppler assessment of left ventricular geometry and function in rats with pressure-overload hypertrophy. Chronic angiotensin-converting enzyme inhibition attenuates the transition to heart failure. Circulation 91 10 (1995) 2642-2654
25. Mantyh P.W., Rogers S.D., Honore P., Allen B.J., Ghilardi J.R., Li J., Daughters R.S., Lappi D.A., Wiley R.G., and Simone D.A. Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor. Science (New York, NY) 278 5336 (1997) 275-279
26. Mason P. Contributions of the medullary raphe and ventromedial reticular region to pain modulation and other homeostatic functions. Annu Rev Neurosci 24 (2001) 737-777
27. Mason P. Deconstructing endogenous pain modulations. J Neurophysiol 94 3 (2005) 1659-1663
28. Mason P. Ventromedial medulla: pain modulation and beyond. J Comp Neurol 493 1 (2005) 2-8
29. Meyerson B.A. Neurosurgical approaches to pain treatment. Acta Anaesthesiol Scand 45 9 (2001) 1108-1113
30. Millan M.J. Descending control of pain. Progr Neurobiol 66 6 (2002) 355-474
31. Morgan M.M., and Whitney P.K. Immobility accompanies the antinociception mediated by the rostral ventromedial medulla of the rat. Brain Res 872 1-2 (2000) 276-281
32. Narayanan S., Surendranath K., Bora N., Surolia A., and Karande A.A. Ribosome inactivating proteins and apoptosis. FEBS Lett 579 6 (2005) 1324-1331
33. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates (2007), Academic Press, Oxford
34. Porreca F., Burgess S.E., Gardell L.R., Vanderah T.W., Malan Jr. T.P., Ossipov M.H., Lappi D.A., and Lai J. Inhibition of neuropathic pain by selective ablation of brainstem medullary cells expressing the mu-opioid receptor. J Neurosci 21 14 (2001) 5281-5288
35. Porreca F., Ossipov M.H., and Gebhart G.F. Chronic pain and medullary descending facilitation. Trends Neurosci 25 6 (2002) 319-325
36. Saarto T., and Wiffen P.J. Antidepressants for neuropathic pain. Cochrane Database of Systematic Reviews (Online) 4 (2007) CD005454
37. Schoeniger-Skinner D.K., Ledeboer A., Frank M.G., Milligan E.D., Poole S., Martin D., Maier S.F., and Watkins L.R. Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120. Brain Behav Immun 21 5 (2007) 660-667
38. Sindrup S.H., and Jensen T.S. Efficacy of pharmacological treatments of neuropathic pain: an update and effect related to mechanism of drug action. Pain 83 3 (1999) 389-400
39. Skaper S.D. The brain as a target for inflammatory processes and neuroprotective strategies. Ann N Y Acad Sci 1122 (2007) 23-34
40. Slavik E., and Ivanovic S. Cancer pain (neurosurgical management). Acta Chir Iugosl 51 4 (2004) 15-23
41. Stein A.B., Tiwari S., Thomas P., Hunt G., Levent C., Stoddard M.F., Tang X.L., Bolli R., and Dawn B. Effects of anesthesia on echocardiographic assessment of left ventricular structure and function in rats. Basic Res Cardiol 102 1 (2007) 28-41
42. Szutowicz A. Aluminum, NO, and nerve growth factor neurotoxicity in cholinergic neurons. J Neurosci Res 66 5 (2001) 1009-1018
43. Tanga F.Y., Raghavendra V., and DeLeo J.A. Quantitative real-time RT-PCR assessment of spinal microglial and astrocytic activation markers in a rat model of neuropathic pain. Neurochem Int 45 2-3 (2004) 397-407
44. Tracey I., and Mantyh P.W. The cerebral signature for pain perception and its modulation. Neuron 55 3 (2007) 377-391
45. Vera-Portocarrero L.P., Xie J.Y., Kowal J., Ossipov M.H., King T., and Porreca F. Descending facilitation from the rostral ventromedial medulla maintains visceral pain in rats with experimental pancreatitis. Gastroenterology 130 7 (2006) 2155-2164
46. Vera-Portocarrero L.P., Zhang E.T., Ossipov M.H., Xie J.Y., King T., Lai J., and Porreca F. Descending facilitation from the rostral ventromedial medulla maintains nerve injury-induced central sensitization. Neuroscience 140 4 (2006) 1311-1320
47. Weisinger H.S., Begg D.P., Egan G.F., Jayasooriya A.P., Lie F., Mathai M.L., Sinclair A.J., Wark J.D., and Weisinger R.S. Angiotensin converting enzyme inhibition from birth reduces body weight and body fat in Sprague-Dawley rats. Physiol Behav 93 4-5 (2008) 820-825
48. Wiffen P., Collins S., McQuay H., Carroll D., Jadad A., and Moore A. Anticonvulsant drugs for acute and chronic pain. Cochrane Database of Systematic Reviews (Online) 3 (2005) CD001133
49. Wiley R.G., and Lappi D.A. Targeted toxins in pain. Adv Drug Del Rev 55 8 (2003) 1043-1054
50. Zagon A. Internal connections in the rostral ventromedial medulla of the rat. J Auton Nerv Syst 53 1 (1995) 43-56
51. Zhang R.X., Liu B., Wang L., Ren K., Qiao J.T., Berman B.M., and Lao L. Spinal glial activation in a new rat model of bone cancer pain produced by prostate cancer cell inoculation of the tibia. Pain 118 1-2 (2005) 125-136
52. Zhang R.X., Wang L., Liu B., Qiao J.T., Ren K., Berman B.M., and Lao L. Mu opioid receptor-containing neurons mediate electroacupuncture-produced anti-hyperalgesia in rats with hind paw inflammation. Brain Res 1048 1-2 (2005) 235-240