Synthesis and evaluation of 6-methylene-bridged uracil derivatives. Part 1: Discovery of novel orally active inhibitors of human thymidine phosphorylase

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 13, 2004, Pages 3431-3441

  Yano, Shingo ^a   Kazuno, Hideki ^a   Suzuki, Norihiko ^a   Emura, Tomohiro ^a   Wierzba, Konstanty ^a   Yamashita, Jun Ichi ^a   Tada, Yukio ^a   Yamada, Yuji ^a   Fukushima, Masakazu ^a   Asao, Tetsuji ^a  

^a TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

2 Deoxy 5 (trifluoromethyl) uridine (F3dThd); 6 Methylene bridged uracil derivative; Thymidine phosphorylase inhibitor; TPI

Indexed keywords

5 BROMO 6 (PYRROLIDINYLMETHYL)URACIL; AMINE; METHYL GROUP; THYMIDINE PHOSPHORYLASE; TRIFLURIDINE; UNCLASSIFIED DRUG; URACIL DERIVATIVE;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG MECHANISM; DRUG POTENTIATION; DRUG SCREENING; DRUG SOLUBILITY; DRUG SYNTHESIS; ENZYME INHIBITION; EXPERIMENTAL TEST; FLUORINATION; IN VIVO STUDY; MOUSE; NONHUMAN; SUBSTITUTION REACTION;

ABSORPTION; ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; ENZYME INHIBITORS; FEMALE; HUMANS; HYDROCARBONS; INHIBITORY CONCENTRATION 50; MACACA FASCICULARIS; MALE; METHANE; MICE; MICE, NUDE; MOLECULAR STRUCTURE; STOMACH NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDINE PHOSPHORYLASE; URACIL; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 2942553016     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.04.036     Document Type: Article

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