Activation of PKC-ε counteracts maturation and apoptosis of HL-60 myeloid leukemic cells in response to TNF family members

European Journal of Histochemistry

Volumn 53, Issue 3, 2009, Pages 177-182

  Gonelli, Arianna ^a   Milani, D ^a   Rimondi, E ^b   Voltan, R ^b   Grill, V ^b   Celeghini, C ^b  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

Author keywords

Acute myeloid leukemia; Apoptosis; HL 60 cells; Maturation; Surface antigens

Indexed keywords

CD14 ANTIGEN; PROTEIN KINASE C EPSILON; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL DEATH; CELL LINEAGE; CELL MATURATION; CELL STRAIN HL 60; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LEUKEMIA CELL; MONOCYTE; PROTEIN EXPRESSION; PROTEIN INTERACTION; CELL DIFFERENTIATION; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; METABOLISM;

APOPTOSIS; CELL DIFFERENTIATION; ENZYME ACTIVATION; HL-60 CELLS; HUMANS; PROTEIN KINASE C-EPSILON; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTOR-ALPHA;

EID: 70849132655     PISSN: 1121760X     EISSN: None     Source Type: Journal    
DOI: 10.4081/ejh.2009.177     Document Type: Article

References (33)

1. Bar-Shavit Z, Teitelbaum SL, Reitsma P, Hall A, Pegg LE, Trial J, et al. Induction of monocytic differentiation and bone resorption by 1,25-dihydroxyvitamin D3. Proc Natl Acad Sci USA 1983; 80:5907-5911 (Pubitemid 14227581)
2. Borgatti P, Mazzoni M, Carini C, Neri LM, Marchisio M, Bertolaso L, et al. Changes of nuclear protein kinase C activity and isotype composition in PC12 cell proliferation and differentiation. Exp Cell Res 1996;224:72-78 (Pubitemid 26116889)
3. Borgatti P, Zauli G, Colamussi ML, Gibellini D, Previati M, Cantley LL, et al. Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells. Eur J Immunol 1997; 27:2805-2811 (Pubitemid 27478347)
4. Brandman R, Disatnik MH, Churchill E, Mochly-Rosen D. Peptides derived from the C2 domain of protein kinase C epsilon (epsilon PKC) modulate epsilon PKC activity and identify potential protein-protein interaction surfaces. J Biol Chem 2007; 282:4113-4123 (Pubitemid 47084489)
5. Braun MU, Mochly-Rosen D. Opposing effects of delta- and zeta-protein kinase C isozymes on cardiac fibroblast proliferation: use of isozyme-selective inhibitors. J Mol Cell Cardiol 2003;35:895-903. (Pubitemid 36871014)
6. Breitman TR, Selonick SE, Collins SJ. Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid. Proc Natl Acad Sci USA 1980;77:2936-2940 (Pubitemid 10049852)
7. Chambon P. The retinoid signaling pathway: molecular and genetic analyses. Semin Cell Biol 1994;5:115-125 (Pubitemid 124003277)
8. Dorn GW 2nd, Souroujon MC, Liron T, Chen CH, Gray MO, Zhou HZ, et al. Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation. Proc Natl Acad Sci USA 1999;96:12798-12803
9. Gillespie S, Zhang XD, Hersey P.Variable expression of protein kinase C epsilon in human melanoma cells regulates sensitivity to TRAIL-induced apoptosis. Mol Cancer Ther 2005;4:668-676 (Pubitemid 40601849)
10. Gobbi G, Mirandola P, Carubbi C, Micheloni C, Malinverno C, Lunghi P, et al. Phorbol ester-induced PKCepsilon down-modulation sensitizes AML cells to TRAIL-induced apoptosis and cell differentiation. Blood 2009; 13:3080-3087
11. Gonelli A, Mischiati C, Guerrini R, Voltan R, Salvadori S, Zauli G. Perspectives of Protein Kinase C (PKC) Inhibitors as Anti-Cancer Agents. Mini Rev Med Chem 2009; 9: 498-509.
12. Hanahan D,Weinberg RA.The hallmarks of cancer. Cell 2000; 100:57-70.
13. Johnson JA, Gray MO, Chen CH, Mochly-Rosen D. A protein kinase C translocation inhibitor as an isozyme-selective antagonist of cardiac function. J Biol Chem 1996;271:24962-24966
14. Li B, Kaetzel MA, Dedman JR. Signaling pathways regulating murine cardiac CREB phosphorylation. Biochem Biophys Res Commun 2006;350:179-184 (Pubitemid 44466589)
15. Li L, Neaves WB. Normal stem cells and cancer stem cells: the niche matters. Cancer Res 2006; 66:4553-4557
16. Lu D, Huang J, Basu A. Protein kinase Cepsilon activates protein kinase B/Akt via DNA-PK to protect against tumor necrosis factor-alpha-induced cell death. J Biol Chem 2006;281:22799-22807 (Pubitemid 44242309)
17. Milani D, Zauli G, Rimondi E, Celeghini C, Marmiroli S, Narducci P, et al.Tumour necrosis factor-related apoptosis-inducing ligand sequentially activates pro-survival and pro-apoptotic pathways in SK-NMC neuronal cells. J Neurochem 2003;86:126-135 (Pubitemid 36753853)
18. Mirandola P, Gobbi G, Ponti C, Sponzilli I, Cocco L, Vitale M. PKCepsilon controls protection against TRAIL in erythroid progenitors. Blood 2006;107:508-513 (Pubitemid 43076372)
19. Okhrimenko H, Lu W, Xiang C, Hamburger N, Kazimirsky G, Brodie C. Protein kinase C-epsilon regulates the apoptosis and survival of glioma cells. Cancer Res 2005;65:7301-7309 (Pubitemid 41161262)
20. Racke FK, Wang D, Zaidi Z, Kelley J, Visvader J, Soh JW, et al. A potential role for protein kinase C-epsilon in regulating megakaryocytic lineage commitment. J Biol Chem 2001;276:522-528 (Pubitemid 32050346)
21. Secchiero P, Gonelli A, Mirandola P, Melloni E, Zamai L, Celeghini C, et al. Tumor necrosis factor-related apoptosis-inducing ligand induces monocytic maturation of leukemic and normal myeloid precursors through a caspase-dependent pathway. Blood 2002; 100:2421-2429
22. Secchiero P, Milani D, Gonelli A, Melloni E, Campioni D, Gibellini D, et al. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and TNF-alpha promote the NF-kappaB-dependent maturation of normal and leukemic myeloid cells. J Leukoc Biol 2003; 74:223-232 (Pubitemid 38040419)
23. Secchiero P, Zerbinati C, Melloni E, Milani D, Campioni D, Fadda R, et al. The MDM-2 antagonist nutlin-3 promotes the maturation of acute myeloid leukemic blasts. Neoplasia 2007;9:853-861 (Pubitemid 47623425)
24. Secchiero P, Zauli G.Tumor-necrosis-factor-related apoptosis-inducing ligand and the regulation of hematopoiesis. Curr Opin Hematol 2008;15:42-48 (Pubitemid 350191027)
25. Sivaprasad U, Shankar E, Basu A. Downregulation of Bid is associated with PKCepsilon-mediated TRAIL resistance. Cell Death Differ 2007;14:851-860 (Pubitemid 46444522)
26. Souroujon MC, Mochly-Rosen D. Peptide modulators of protein-protein interactions in intracellular signaling. Nat Biotechnol 1998; 16:919-924 (Pubitemid 28483618)
27. Todd RF, Nadler LM, Schlossman SF. Antigens on human monocytes identified by monoclonal antibodies. J Immunol 1981;126:1435-1439
28. Vitale M, Zamai L, Falcieri E, Zauli G, Gobbi P, Santi S, et al. IMP dehydrogenase inhibitor, tiazofurin, induces apoptosis in K562 human erythroleukemia cells. Cytometry 1997;30:61-66 (Pubitemid 27157846)
29. Yonezawa T, Kurata R, Kimura M, Inoko H. PKC delta and epsilon in drug targeting and therapeutics. Recent Pat DNA Gene Seq 2009; 3:96-101.
30. Zauli G,Visani G, Bassini A, Caramelli E, Ottaviani E, Bertolaso L, et al. Nuclear translocation of protein kinase C-alpha and -zeta isoforms in HL-60 cells induced to differentiate along the granulocytic lineage by all-trans retinoic acid. Br J Haematol 1996;93:542-550 (Pubitemid 126443422)
31. Zauli G, Pandolfi A, Gonelli A, Di Pietro R, Guarnieri S, Ciabattoni G, et al. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sequentially upregulates nitric oxide and prostanoid production in primary human endothelial cells. Circ Res 2003;92:732-740 (Pubitemid 36457637)
32. Zauli G, Secchiero P.The role of the TRAIL/TRAIL receptors system in hematopoiesis and endothelial cell biology. Cytokine Growth Factor Rev 2006;17:245-257 (Pubitemid 44038614)
33. Zhang DE, Hetherington CJ, Gonzalez DA, Chen HM, Tenen DG. Regulation of CD14 expression during monocytic differentiation induced with 1a,25-dihydroxyvitamin D3. J. Immunol 1994;153: 3276-3284 (Pubitemid 2154574)