Deoxynivalenol suppresses circulating and splenic leukocyte subpopulations in BALB/c mice: Dose response, time course and sex differences

Food Additives and Contaminants - Part A

Volumn 26, Issue 7, 2009, Pages 1070-1080

  Wu, Xianai ^a   Kohut, Marian ^a   Cunnick, Joan ^a   Bailey, Ted ^b   Hendrich, Suzanne ^a  

^a IOWA STATE UNIVERSITY   (United States)

^b Department of Statistics Center for Statistics and Applications in Forensic Evidence Iowa State University 2438 Osborn Dr Ames   (United States)

Author keywords

BALB c mice; Cell surface markers; Deoxynivalenol

Indexed keywords

CD11B ANTIGEN; CD19 ANTIGEN; VOMITOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; BAGG ALBINO MOUSE; CONTROLLED STUDY; FEMALE; FOOD CONTAMINATION; FUNGAL CONTAMINATION; FUSARIUM GRAMINEARUM; IMMUNOTOXICITY; LEUKOCYTE; MALE; MONOCYTE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SEX DIFFERENCE;

GIBBERELLA ZEAE; MUS;

EID: 70849131133     PISSN: 19440049     EISSN: 14645122     Source Type: Journal    
DOI: 10.1080/02652030902832959     Document Type: Article

References (47)

1. Ansar Ahmed S, Talal N. 1990. Sex hormones and the immune system. Part 2. Animal data. Bailliere's Clin Rheumatol. 4:13-31.
2. Avantaggiato G, Havenaar R, Visconti A. 2004. Evaluation of the intestinal absorption of deoxynivalenol and nivalenol by an in vitro gastrointestinal model, and the binding efficacy of activated carbon and other adsorbent materials. Food Chem Toxicol. 42(5):817-824.
3. Christian Larsen J, Hunt J, Perrin I, Ruckenbauer P. 2004. Workshop on trichothecenes with focus on DON: Summary report. Toxicol Lett. 153:1-22.
4. Cirillo T, Ritieni A, Galvano F, Amodio Cocchieri R. 2003. Natural co-occurrence of deoxynivalenol and fumonisins B1 and B2 in Italian marketed foodstuffs. Food Addit Contam. 20(6):566-571.
5. Codex Committee on Food Additives and Contaminants. 2005. Deoxynivalenol (DON) contamination in cereals (CX/FAC). Available: http://ec.europa.eu/food/fs/ifsi/eupositions/ccfac/ccfac_agenda_item16e_en.pdf. Accessed 11 October 2008.
6. Danicke S, Valenta H, Doll S. 2004. On the toxicokinetics and the metabolism of deoxynivalenol (DON) in the pig. Arch Anim Nutr. 58(2):169-180.
7. Eriksen GS, Pettersson H, Lindberg JE. 2003. Absorption, metabolism and excretion of 3-Ac DON in pigs. Arch Tierernahr. 57(5):335-345.
8. Froquet R, Arnold F, Batina P, Parent-Massin D. 2003. Do trichothecenes reduce viability of circulating blood cells and modify haemostasis parameters? Mycopathology. 156:349-356.
9. Froquet R, Sibiril Y, Parent-Massin D. 2001. Trichothecene toxicity on human megakaryocyte progenitors (CFU-MK). Hum Exp Toxicol. 20:84-89.
10. Forsell HJ, Witt FM, Tai HJ, Jensen R, Pestka JJ. 1986. Effects of 8-week exposure of the B6C3F1 mouse to dietary deoxynivalenol (vomitoxin) and zearalenone. Food Chem Toxicol. 24(3):213-219.
11. Gouze ME, Laffitte J, Rouimi P, Loiseau N, Oswald IP, Galtier P. 2006. Effect of various doses of deoxynivalenol on liver xenobiotic metabolizing enzymes in mice. Food Chem Toxicol. 44:476-83.
12. Hedman R, Pettersson H. 1997. Transformation of nivalenol by gastrointestinal microbes. Arch Tierernahr. 50:321-329.
13. Hu Z, Wells P. 2004. Human interindividual variation in lymphocyte UDP-glucuronosyltransferases as a determinant of in vitro benzo[a]pyrene covalent binding and cytotoxicity. Toxicol Sci. 78:32-40.
14. Iverson F, Armstrong C, Nera E, Truelove J, Fernie S, Scott P, Stapley R, Hayward S, Gunner S. 1996. Chronic feeding study of deoxynivalenol in B6C3F1 male and female mice. Teratog Carcinog Mutagen. 15:283-306.
15. Klein SL. 2004. Hormonal and immunological mechanisms mediating sex differences in parasite infection. Parasitol Immunol. 26:247-264.
16. Kuiper-Goodman T, Scott PM, Watanabe H. 1987. Risk assessment of the mycotoxin zearalenone. Regul Toxicol Pharmacol. 7:253-306.
17. Landgren CA. 2005. Murine immunodulation by low-dose dietary deoxynivalenol and improved detection methods for deoxynivalenol. Dissertation. Ames: Iowa State University.
18. Landgren CA, Kohut ML, Hendrich S. 2006. Low-level dietary deoxynivalenol and acute exercise stress result in immunotoxicity in BALB/c mice. J Immunotoxicol. 3:173-8.
19. Lautraite S, Parent-Massin D, Rio B, Hoellinger H. 1997. In vitro toxicity induced by deoxynivalenol (DON) on human and rat granulomonocytic progenitors. Cell Biol Toxicol. 13:175-183.
20. Le Drean G, Auffret M, Batina P, Arnold F, Sibiril Y, Arzur D, Parent-Massin D. 2005. Myelotoxicity of trichothecenes and apoptosis: an in vitro study on human cord blood CD34{thorn} hematopoietic progenitor. Toxicol In Vitro. 19:1015-1024.
21. Lombaert GA, Pellaers P, Roscoe V, Mankotia M, Neil R, Scott PM. 2003. Mycotoxins in infant cereal foods from the Canadian retail market. Food Addit Contam. 20: 494-504.
22. Luster IM, Germolec RD, Kayama F, Rosenthal JG, Comment EC, Wilmer LJ. 1996. Experimental immuntoxicology. In: Smialowicz JR, Holsapple PM, editors. Approaches and concepts in immunotoxicity, chapter 2.
23. Boca Raton, FL: CRC Press. p. 13-28.
24. Meky FA, Turner PC, Ashcroft AE, Miller JD, Qiao YL, Roth MJ, Wild CP. 2003. Development of a urinary biomarker of human exposure to deoxynivalenol. Food Chem Toxicol. 41:265-73.
25. Minervini F, Fornelli F, Flynn KM. 2004. Toxicity and apoptosis induced by the mycotoxins nivalenol, deoxynivalenol and fumonisin B1 in a human erythroleukemia cell line. Toxicol In Vitro. 18:21-28.
26. Parent-Massin D. 2004. Haematotoxicity of trichothecenes. Toxicol Lett. 153:75-81.
27. Pasche B, Kalaydjiev S, Franz TJ, Kremmer E, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Lengeling A, Busch DH. 2005. Sex-dependent susceptibility to Listeria monocytogenes infection is mediated by differential interleukin-10 production. Infect Immun. 73:5952-5960.
28. Pestka JJ. 2008. Mechanisms of deoxynivalenol-induced gene expression and apoptosis. Food Addit Contam. 24:1-13.
29. Pestka JJ, Islam Z, Amuzie CJ. 2008. Immunochemical assessment of deoxynivalenol tissue distribution following oral exposure in the mouse. Toxicol Lett. 178(2):83-87.
30. Pestka JJ, Smolinski AT. 2005. Deoxynivalenol: toxicology and potential effects on humans. J Toxicol Environ Health B. 8:39-69.
31. Pestka JJ, Tai HJ, Witt FM, Dixon ED, Forsell HJ. 1987. Suppression of immune response in the B6C3F1 mouse after dietary exposure to the fusarium mycotoxins deoxynivalenol (vomitoxin) and zearalenone. Food Chem Toxicol. 25:297-304.
32. Picker JL, Butcher CE. 1992. Physiological and molecular mechanisms of lymphocyte homing. Annu Rev Immunol. 10:561-591.
33. Pruett S, Hebert P, Lapointe JM, Reagan W, Lawton M, Kawabata TT. 2007. Characterization of the action of drug-induced stress response on the immune system: evaluation of biomarkers for drug-induced stress in rats. J Immunotoxicol. 4(1):25-38.
34. Reeves GP. 1997. Components of the AIN-93 diets as improvements in the AIN-76A diet American society for nutritional sciences (symposium: animal diets for nutritional and toxicological research). J Nutr. 127: 838s-841s.
35. Robbana-Barnat S, Loridon-Rosa B, Cohen H, Lafarge-Frayssinet C, Neish GA, Frayssient C. 1987. Protein synthesis inhibition and cardiac lesions associated with deoxynivalenol ingestion in mice. Food Addit Contam. 4:49-55.
36. Roscoe V, Lombaert GA, Huzel V, Neumann G, Melietio J, Kitchen D, Kotello S, Krakalovich T, Trelka R, Scott PM. 2008. Mycotoxins in breakfast cereals from the Canadian retail market: A 3-year survey. Food Addit Contam. 25(3): 347-55.
37. Rotter BA, Thompson BK, Lessard M, Trenholm HL, Tryphonas H. 1994. Influence of low-level exposure to Fusarium mycotoxins on selected immunological and hematological parameters in young swine. Fundam Appl Toxicol. 23:117-124.
38. Schollenberger M, Jara HT, Suchy S, Drochner W, Muller HM. 2002. Fusarium toxins in wheat flour collected in an area in southwest Germany. Int J Food Microbiol. 72(1-2):85-9.
39. Stefano GB, Peter D. 2001. Cell surface estrogen receptors coupled to cNOS mediate immune and vascular tissue regulation: therapeutic implications. Med Sci Monit. 7:1066-1074.
40. Sundstol Eriksen G, Pettersson H, Lundh T. 2004. Comparative cytotoxicity of deoxynivalenol, nivalenol, their acetylated derivatives and de-epoxy metabolites. Food Chem Toxicol. 42:619-624.
41. Trucksess MW, Thomas F, Young K, Stack ME, Fulgueras WJ, Page SW. 1995. Survey of deoxynivalenol in US 1993 wheat and barley crops by enzyme-linked immunosorbent assay. J AOAC Int. 78:631-636.
42. Tryphonas H, Iverson F, So Y, Nera EA, McGuire PF, O'Grady L, Clayson DB, Scott PM. 1986. Effects of deoxynivalenol (vomitoxin) on the humoral and cellular immunity of mice. Toxicol Lett. 30(2):137-50.
43. Ueno Y, Umemori K, Niimi E, Tanuma S, Nagata S, Sugamata M, lhara T, Sekijima M, Kawai K, Ueno I, Tashiro F. 1995. Induction of apoptosis by T-2 toxin and other natural toxins in HL-60 human promyelotic leukemia cells. Nat Toxins. 3:129-137.
44. Uzarski RL, Pestka JJ. 2003. Comparative susceptibility of B cells with different lineages to cytotoxicity and apoptosis induction by translational inhibitors. J Toxicol Environ Health A. 66:2105-2118.
45. Worrell NR, Mallett AK, Cook WM, Baldwin NC, Shepherd MJ. 1989. The role of gut micro-organisms in the metabolism of deoxynivalenol administered to rats. Xenobiotica. 19:25-32.
46. Wu X, Murphy P, Cunnick J, Hendrich S. 2007. Synthesis and characterization of deoxynivalenol glucuronide: its comparative immunotoxicity with deoxynivalenol. Food Chem Toxicol. 45:1846-1855.
47. Zhu J, Emerson SG. 2002. Hematopoietic cytokines, transcription factors and lineage commitment. Oncogene. 21:3295-3313.