Molecular determinant of regioselective hydroxylation of docetaxel by CYP3A4

Molecular and Cellular Pharmacology

Volumn 1, Issue 2, 2009, Pages 76-84

  Monsarrat, Bernard ^a   Thoison, Odile ^b   Dubois, Joelle ^b   Cresteil, Thierry ^b  

^a INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^b INSTITUT DE CHIMIE DES SUBSTANCES NATURELLES   (France)

Author keywords

Biotransformation; CYP2C; CYP3A4; Docetaxel; Human liver; Paclitaxel

Indexed keywords

10 BUTANOYLDOCETAXEL; 10 NONANOYLDOCETAXEL; 10 OCTANOYLDOCETAXEL; ACETIC ACID DERIVATIVE; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; DOCETAXEL; DRUG METABOLITE; PACLITAXEL; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG HYDROXYLATION; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER MICROSOME; MASS SPECTROMETRY; OXIDATION; SUBSTITUTION REACTION;

EID: 70849102369     PISSN: None     EISSN: 19381247     Source Type: Journal    
DOI: 10.4255/mcpharmacol.09.09     Document Type: Article

References (13)

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