P63 directly induces expression of Alox12, a regulator of epidermal barrier formation

Experimental Dermatology

Volumn 18, Issue 12, 2009, Pages 1016-1021

  Kim, Soeun ^a   Choi, Irene F ^b   Quante, Jessica R ^b   Zhang, Lei ^b   Roop, Dennis R ^b   Koster, Maranke I ^b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Alox12; Epidermal barrier; Epidermal development; P63

Indexed keywords

LIPOXYGENASE; PROTEIN ALOX12; PROTEIN P63; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DEVELOPMENTAL STAGE; EPIDERMIS; GENE INDUCTION; GENE INTERACTION; MOUSE; NEWBORN; NONHUMAN; PERINATAL PERIOD; PERMEABILITY BARRIER; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SKIN FUNCTION; SKIN PERMEABILITY;

ANIMALS; ARACHIDONATE 12-LIPOXYGENASE; CALCIUM; CELL DIFFERENTIATION; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; DNA; DOWN-REGULATION; ENZYME INDUCTION; EPIDERMIS; GENES, REPORTER; I-KAPPA B KINASE; KERATINOCYTES; LUCIFERASES; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MIFEPRISTONE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHOPROTEINS; POINT MUTATION; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RESPONSE ELEMENTS; SKIN; TRANS-ACTIVATORS; TRANSDUCTION, GENETIC;

EID: 70849098307     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/j.1600-0625.2009.00894.x     Document Type: Article

References (40)

1. Koch P J, Zhou Z, Roop D R, Elias P M, Feingold K R. Cornified envelope and corneocyte-lipid envelope. Skin Barrier 2004, 97-110. In, eds, Marcel Dekker, Inc, New York
2. Elias P M, Feingold K R. Lipids and the epidermal water barrier: metabolism, regulation, and pathophysiology. Semin Dermatol 1992, 11:176-182.
3. Segre J. Complex redundancy to build a simple epidermal permeability barrier. Curr Opin Cell Biol 2003, 15:776-782.
4. Cartlidge P. The epidermal barrier. Semin Neonatol 2000, 5:273-280.
5. Elias P M, Hatano Y, Williams M L. Basis for the barrier abnormality in atopic dermatitis: outside-inside-outside pathogenic mechanisms. J Allergy Clin Immunol 2008, 121:1337-1343.
6. Elias P M, Williams M L, Holleran W M, Jiang Y J, Schmuth M. Thematic review series: skin lipids. Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism. J Lipid Res 2008, 49:697-714.
7. Brash A R. Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate. J Biol Chem 1999, 274:23679-23682.
8. Eckl K M, Krieg P, Kuster W. Mutation spectrum and functional analysis of epidermis-type lipoxygenases in patients with autosomal recessive congenital ichthyosis. Hum Mutat 2005, 26:351-361.
9. Yu Z, Schneider C, Boeglin W E, Brash A R. Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3. Biochim Biophys Acta (BBA) - Mol Cell Biol Lipids 2005, 1686:238-247.
10. Jobard F, Lefevre C, Karaduman A. Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1. Hum Mol Genet 2002, 11:107-113.
11. Johnson E N, Nanney L B, Virmani J, Lawson J A, Funk C D. Basal transepidermal water loss is increased in platelet-type 12-lipoxygenase deficient mice. J Invest Dermatol 1999, 112:861-865.
12. Hussain H, Shornick L P, Shannon V R. Epidermis contains platelet-type 12-lipoxygenase that is overexpressed in germinal layer keratinocytes in psoriasis. Am J Physiol Cell Physiol 1994, 266:C243-C253.
13. Takahashi Y, Reddy G R, Ueda N, Yamamoto S, Arase S. Arachidonate 12-lipoxygenase of platelet-type in human epidermal cells. J Biol Chem 1993, 268:16443-16448.
14. Heidt M, Furstenberger G, Vogel S, Marks F, Krieg P. Diversity of mouse lipoxygenases: identification of a subfamily of epidermal isozymes exhibiting a differentiation-dependent mRNA expression pattern. Lipids 2000, 35:701-707.
15. Koster M I, Kim S, Mills A A, DeMayo F J, Roop D R. p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev 2004, 18:126-131.
16. Yang A, Schweitzer R, Sun D. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 1999, 398:714-718.
17. Mills A A, Zheng B, Wang X J, Vogel H, Roop D R, Bradley A. p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 1999, 398:708-713.
18. Yang A, Kaghad M, Wang Y. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell 1998, 2:305-316.
19. Koster M I, Roop D R. Sorting out the p63 signaling network. J Invest Dermatol 2008, 128:1617-1619.
20. Dohn M, Zhang S, Chen X. p63alpha and DeltaNp63alpha can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes. Oncogene 2001, 20:3193-3205.
21. Helton E S, Zhu J, Chen X. The Unique NH2-terminally deleted ({Delta}N) residues, the PXXP motif, and the PPXY motif are required for the transcriptional activity of the {Delta}N variant of p63. J Biol Chem 2006, 281:2533-2542.
22. Koster M I, Dai D, Marinari B. p63 induces key target genes required for epidermal morphogenesis. Proc Natl Acad Sci U S A 2007, 104:3255-3260.
23. Yuspa S H, Kilkenny A E, Steinert P M, Roop D R. Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro. J Cell Biol 1989, 109:1207-1217.
24. Hu Y, Baud V, Oga T, Kim K I, Yoshida K, Karin M. IKKalpha controls formation of the epidermis independently of NF-kappaB. Nature 2001, 410:710-714.
25. Truong A B, Kretz M, Ridky T W, Kimmel R, Khavari P A. p63 regulates proliferation and differentiation of developmentally mature keratinocytes. Genes Dev 2006, 20:3185-3197.
26. Yang A, Zhu Z, Kapranov P. Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells. Mol Cell 2006, 24:593-602.
27. Della Gatta G, Bansal M, Ambesi-Impiombato A, Antonini D, Missero C, di Bernardo D. Direct targets of the TRP63 transcription factor revealed by a combination of gene expression profiling and reverse engineering. Genome Res 2008, 18:939-948.
28. Birkaya B, Ortt K, Sinha S. Novel in vivo targets of DeltaNp63 in keratinocytes identified by a modified chromatin immunoprecipitation approach. BMC Mol Biol 2007, 8:43.
29. Osada M, Park H L, Nagakawa Y. Differential recognition of response elements determines target gene specificity for p53 and p63. Mol Cell Biol 2005, 25:6077-6089.
30. Zeng S X, Dai M S, Keller D M, Lu H. SSRP1 functions as a co-activator of the transcriptional activator p63. EMBO J 2002, 21:5487-5497.
31. MacPartlin M, Zeng S, Lee H. p300 regulates p63 transcriptional activity. J Biol Chem 2005, 280:30604-30610.
32. Ihrie R A, Marques M R, Nguyen B T. Perp is a p63-regulated gene essential for epithelial integrity. Cell 2005, 120:843-856.
33. Marinari B, Ballaro C, Koster M I. IKKα is a p63 transcriptional target involved in the pathogenesis of ectodermal dysplasias. J Invest Dermatol 2009, 129:60-69.
34. Nguyen B C, Lefort K, Mandinova A. Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation. Genes Dev 2006, 20:1028-1042.
35. Menon G K, Elias P M, Lee S H, Feingold K R. Localization of calcium in murine epidermis following disruption and repair of the permeability barrier. Cell Tissue Res 1992, 270:503-512.
36. Elias P M, Nau P, Hanley K. Formation of the epidermal calcium gradient coincides with key milestones of barrier ontogenesis in the rodent. J Invest Dermatol 1998, 110:399-404.
37. Elias P M, Ahn S K, Denda M. Modulations in epidermal calcium regulate the expression of differentiation-specific markers. J Invest Dermatol 2002, 119:1128-1136.
38. Yuki T, Haratake A, Koishikawa H, Morita K, Miyachi Y, Inoue S. Tight junction proteins in keratinocytes: localization and contribution to barrier function. Exp Dermatol 2007, 16:324-330.
39. Jackson B, Tilli C M L J, Hardman M J. Late cornified envelope family in differentiating epithelia-response to calcium and ultraviolet irradiation. J Investig Dermatol 2005, 124:1062-1070.
40. King K E, Ponnamperuma R M, Gerdes M J. Unique domain functions of p63 isotypes that differentially regulate distinct aspects of epidermal homeostasis. Carcinogenesis 2006, 27:53-63.