Rac1 contributes to actin organization in glomerular podocytes

Nephron - Experimental Nephrology

Volumn 114, Issue 3, 2010, Pages

  Attias, Ortal ^a   Jiang, Ruihua ^a   Aoudjit, Lamine ^a   Kawachi, Hiroshi ^b   Takano, Tomoko ^a  

^a MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

Author keywords

Glomerular podocytes; Rac1; Rho GTPases

Indexed keywords

IQ MOTIF CONTAINING GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN 1; NEPHRIN; PUROMYCIN AMINONUCLEOSIDE; RAC1 PROTEIN;

ACTIN FILAMENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; LAMELLIPODIUM; MALE; MOUSE; NEPHROSIS; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ACTINS; ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; CYTOSKELETON; ENZYME ACTIVATION; KIDNEY GLOMERULUS; MALE; MEMBRANE PROTEINS; MICE; NEPHROSIS; PODOCYTES; PUROMYCIN AMINONUCLEOSIDE; RAC1 GTP-BINDING PROTEIN; RAS GTPASE-ACTIVATING PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RHOA GTP-BINDING PROTEIN;

EID: 70849084553     PISSN: 16602129     EISSN: None     Source Type: Journal    
DOI: 10.1159/000262317     Document Type: Article

References (26)

1. Wiggins RC: The spectrum of podocytopathies: a unifying view of glomerular diseases. Kidney Int 2007;71:1205-1214.
2. Burridge K, Wennerberg K: Rho and Rac take center stage. Cell 2004;116:167-179.
3. Narumiya S, Ishizaki T, Watanabe N: Rhoeffectors and reorganization of actin cytoskeleton. FEBS Lett 1997;410:68-72.
4. Togawa A, Miyoshi J, Ishizaki H, et al: Progressive impairment of kidneys and reproductive organs in mice lacking Rho GDIalpha. Oncogene 1999;18:5373-5380.
5. Shibata S, Nagase M, Yoshida S, et al: Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease. Nat Med 2008;14:1370-1376.
6. Asanuma K, Yanagida-Asanuma E, Faul C, Tomino Y, Kim K, Mundel P: Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling. Nat Cell Biol 2006;8:485-491.
7. Yanagida-Asanuma E, Asanuma K, Kim K, et al: Synaptopodin protects against proteinuria by disrupting Cdc42:IRSp53:Mena signaling complexes in kidney podocytes. Am J Pathol 2007;171:415-427.
8. Gao SY, Li CY, Chen J, et al: Rho-ROCK signal pathway regulates microtubule-based process formation of cultured podocytes - inhibition of ROCK promoted process elongation. Nephron Exp Nephrol 2004;97:49-61.
9. Leeuwen FN, Kain HE, Kammen RA, et al: The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; opposing roles for the small GTPases Rac and Rho. J Cell Biol 1997;139:797-807.
10. Li H, Lemay S, Aoudjit L, et al: SRC-family kinase Fyn phosphorylates the cytoplasmic domain of nephrin and modulates its interaction with podocin. J Am Soc Nephrol 2004;15:3006-3015.
11. Jadeski L, Mataraza JM, Jeong HW, et al: IQGAP1 stimulates proliferation and enhances tumorigenesis of human breast epithelial cells. J Biol Chem 2008;283:1008-1017.
12. Endlich N, Kress KR, Reiser J, et al: Podocytes respond to mechanical stress in vitro. J Am Soc Nephrol 2001;12:413-422.
13. Harada R, Vadnais C, Sansregret L, et al: Genome-wide location analysis and expression studies reveal a role for p110 CUX1 in the activation of DNA replication genes. Nucleic Acids Res 2008;36:189-202.
14. Li H, Zhu J, Aoudjit L, Latreille M, Kawachi H, Larose L, Takano T: Rat nephrin modulates cell morphology via the adaptor protein Nck. Biochem Biophys Res Commun 2006;349:310-316.
15. Zhu J, Sun N, Aoudjit L, et al: Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes. Kidney Int 2008;73:556-566.
16. Mundel P, Reiser J, Zuniga Mejia Borja A, et al: Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines. Exp Cell Res 1997;236:248-258.
17. Shankland SJ, Pippin J W, Reiser J, et al: Podocytes in culture: past, present, and future. Kidney Int 2007;72:26-36.
18. Jones N, Blasutig IM, Eremina V, Ruston JM, Bladt F, Li H, Huang H, Larose L, Li SS, Takano T, Quaggin SE, Pawson T: Nck adaptor proteins link nephrin to the actin cyto-skeleton of kidney podocytes. Nature 2006;440:818-823.
19. Liu XL, Kilpelainen P, Hellman U, Sun Y, Wartiovaara J, Morgunova E, Pikkarainen T, Yan K, Jonsson AP, Tryggvason K: Characterization of the interactions of the nephrin intracellular domain. FEBS J 2005;272:228-243.
20. Brown MD, Sacks DB: IQGAP1 in cellular signaling: bridging the GAP. Trends Cell Biol 2006;16:242-249.
21. Jalink K, van Corven EJ, Hengeveld T, et al: Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho. J Cell Biol 1994;126:801-810.
22. Kozma R, Sarner S, Ahmed S, et al: Rho family GTPases and neuronal growth cone remodelling: relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid. Mol Cell Biol 1997;17:1201-1211.
23. Kurokawa K, Nakamura T, Aoki K, et al: Mechanism and role of localized activation of Rho-family GTPases in growth factor-stimulated fibroblasts and neuronal cells. Biochem Soc Trans 2005;33:631-634.
24. Verma R, Kovari I, Soofi A, Nihalani D, Patrie K, Holzman LB: Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization. J Clin Invest 2006;116:1346-1359.
25. Briggs MW, Sacks DB: IQGAP proteins are integral components of cytoskeletal regulation. EMBO Rep 2003;4:571-574.
26. Reiser J, Oh J, Shirato I, et al: Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and alpha3 integrin. J Biol Chem 2004;279:34827-34832.