Design, synthesis, and pharmacological evaluation of some 2-[4-morpholino]-3-aryl-5-substituted thiophenes as novel anti-inflammatory agents: Generation of a novel anti-inflammatory pharmacophore

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 17, 2004, Pages 4667-4671

  Pillai, Ajay D ^a   Rathod, Parendu D ^b   Xavier, Franklin P ^b   Vasu, Kamala K ^b   Padh, Harish ^b   Sudarsanam, Vasudevan ^b  

^a M S RAMAIAH UNIVERSITY OF APPLIED SCIENCES   (India)

^b Thaltej Gandhinagar Hwy T ^*  (India)

Author keywords

Carrageenin; Pharmacophore; Rat paw edema; Thiophene

Indexed keywords

5 (3,5 DIMETHYL 4 METHOXY 2 PYRIDYL) 2 (4 MORPHOLINO) 3 (4 THIOMETHYLPHENYL)THIOPHENE; 5 (3,5 DIMETHYL 4 METHOXY 2 PYRIDYL) 2 (4 MORPHOLINO) 3 PHENYLTHIOPHENE; 5 (4 ACETYLAMINOBENZOYL) 2 (4 MORPHOLINO) 3 (4 CHLOROPHENYL)THIOPHENE; 5 (4 ACETYLAMINOBENZOYL) 2 (4 MORPHOLINO) 3 PHENYLTHIOPHENE; 5 (4 CHLOROBENZOYL) 2 (4 MORPHOLINO) 3 (4 CHLOROPHENYL)THIOPHENE; 5 (4 CHLOROBENZOYL) 2 (4 MORPHOLINO) 3 (4 METHYLTHIOPHENYL)THIOPHENE; 5 (4 CHLOROBENZOYL) 2 (4 MORPHOLINO) 3 PHENYLTHIOPHENE; 5 (4 METHYLMERCAPTOBENZOYL) 2 (4 MORPHOLINO) 3 (4 CHLOROPHENYL)THIOPHENE; 5 (4 METHYLMERCAPTOBENZOYL) 2 (4 MORPHOLINO) 3 (4 METHYLTHIOPHENYL) THIOPHENE; 5 (4 METHYLMERCAPTOBENZOYL) 2 (4 MORPHOLINO) 3 PHENYLTHIOPHENE; 5 (4 METHYLSULFONYLBENZOYL) 2 (4 MORPHOLINO) 3 (4 CHLOROPHENYL)THIOPHENE; 5 (4 METHYLSULFONYLBENZOYL) 2 (4 MORPHOLINO) 3 (4 METHYLTHIOPHENYL) THIOPHENE; 5 (4 METHYLSULFONYLBENZOYL) 2 (4 MORPHOLINO) 3 PHENYLTHIOPHENE; ANTIINFLAMMATORY AGENT; IBUPROFEN; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL COMPOSITION; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; MALE; NONHUMAN; PAW EDEMA; PHARMACOPHORE; RAT; SUBSTITUTION REACTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; DISEASE MODELS, ANIMAL; DRUG DESIGN; EDEMA; IBUPROFEN; MORPHOLINES; PYRIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS; SULFONES; THIOPHENES;

EID: 3843137260     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.06.028     Document Type: Article

References (4)

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2. Pillai, A. D. Ph.D. Dissertation, Bhavngar University, 2002
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4. C.A. Winter, E.A. Risley, and G.W. Nuss Proc. Soc. Exp. Biol. Med. 111 1962 544 547