Gene-gene interaction between interleukin-6 and interleukin-10 reduces AD risk

Neurology

Volumn 63, Issue 6, 2004, Pages 1135-1136

  Infante, J ^a   Sanz, C ^b   Fernandez Luna J L ^b   Llorca, J ^a   Berciano, J ^a   Combarros, O ^a,b  

^a UNIVERSITY OF CANTABRIA   (Spain)

^b HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 6;

ADULT; AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA POLYMORPHISM; FEMALE; GENE INTERACTION; GENE OVEREXPRESSION; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

EID: 4644319999     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.WNL.0000138570.96291.A8     Document Type: Article

References (7)

1. Remarque EJ, Bollen ELEM, Weverling-Rijnsburger AWE, Laterveer JC, Blauw GJ, Westendorp RGJ. Patients with Alzheimer's disease display a pro-inflammatory phenotype. Exp Gerontol 2001;36:171-176.
2. Bhqjak TJ, DeKosky ST, Ganguli M, Kamboh MI. Genetic polymorphisms in the cathepsin D and interleukin-6 genes and the risk of Alzheimer's disease. Neurosci Lett 2000;288:21-24.
3. Pola R, Flex A, Gaetani E, et al. The -174 G/C polymorphism of the interleukin-6 gene promoter is associated with Alzheimer's disease in an Italian population. Neuroreport 2002;13:1645-1647.
4. Lio D, Licastro F, Scola L, et al. Interleukin-10 promoter polymorphism in sporadic Alzheimer's disease. Mol Psychiatry 2003;4:234-238.
5. Depboylu C, Du Y, Müller U, et al. Lack of association of interleukin-10 promoter region polymorphisms with Alzheimer's disease. Neurosci Lett 2003;342:132-134.
6. Fishman D, Faulds G, Jeffery R, et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 1998;102:1369-1376.
7. Kilpinen S, Huhtala H, Hurme M. The combination of the interleukin-1alpha (IL-1alpha-889) genotype and the interleukin-10 (IL-10 ATA) haplotype is associated with increased interleukin-10 (IL-10) plasma levels in healthy individuals. Eur Cytokine Netw 2002;13:66-71.