Fluoroquinolones lower constitutive H2AX and ATM phosphorylation in TK6 lymphoblastoid cells via modulation of the intracellular redox status

Pharmacological Reports

Volumn 61, Issue 4, 2009, Pages 711-718

  Halicka, H Dorota ^a   Smart, Daniel J ^a,b   Traganos, Frank ^a   Williams, Gary M ^a   Darzynkiewicz, Zbigniew ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Cell cycle; Constitutive activation of ATM; Constitutive histone H2AX phosphorylation; DNA double strand breaks; Fluoroquinolones; ROS scavenging

Indexed keywords

ANTIOXIDANT; ATM PROTEIN; BIOLOGICAL MARKER; CIPROFLOXACIN; ENROFLOXACIN; GATIFLOXACIN; GENOMIC DNA; HISTONE H2AX; LOMEFLOXACIN; OFLOXACIN; PHOSPHATIDYLINOSITOL 3 KINASE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; REACTIVE OXYGEN METABOLITE; SERINE;

AGING; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DOUBLE STRANDED DNA BREAK; DRUG STRUCTURE; ENZYME ACTIVATION; GENE MUTATION; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL; MITOCHONDRION; NEOPLASM; OXIDATION REDUCTION STATE; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

EID: 70549098263     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/S1734-1140(09)70124-0     Document Type: Article

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