Studies on the mechanism of phototoxicity of BAY y 3118 and other quinolones

Advances in Experimental Medicine and Biology

Volumn 387, Issue , 1996, Pages 117-120

  Schmidt, U ^a   Schluter G ^a  

^a BAYER AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

8 CHLORO 1 CYCLOPROPYL 7 (2,8 DIAZABICYCLO[4.3.0]NON 8 YL) 6 FLUORO 1,4 DIHYDRO 4 OXO 3 QUINOLINECARBOXYLIC ACID; ALPHA TOCOPHEROL; BAY Y 3114; GLUTATHIONE; LOMEFLOXACIN; NALIDIXIC ACID; OFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RADICAL; SCAVENGER; SPARFLOXACIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG STRUCTURE; GUINEA PIG; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PHOTODEGRADATION; PHOTOTOXICITY; PRIORITY JOURNAL; SKIN; SPECIES DIFFERENCE; TOXICOKINETICS; ULTRAVIOLET A RADIATION;

EID: 0029739914     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4757-9480-9_16     Document Type: Conference Paper

References (6)

1. VOHR, H.W., Bayer AG Pharma Report no.22921 (1994)
2. DAYHAW-BARKER, P. and TRUSCOTT, T.G., Direct detection of singlet oxygnen sensitized by nalidixic acid:The effect of pH and melanin, Photochemistry and Photobiology, 47(5) pp. 765-767 (1988)
3. WAGAI, N. and TAWARA, K., Important role of oxygen metabolites in quinolone antibacterial agent-induced cutaneous phototoxicity in mice, Archives of Toxicology, 65, 495-499 (1991)
4. ROBERTSON, D.G.; EPLING, G.A.; KIELY, J.S; BAILEY, D.L. and SONG, B., Mechanistic studies of the phototoxic potential of PD 117596, a quinolone antibacterial compound, Toxicology and Applied Pharmacology, 111, 221-232 (1991)
5. WAGAI, N. and TAWARA, K., Possible direct role of reactive oxygens in the cause of cutaneous phototoxicity induced by five quinolones in mice. Archives of Toxicology, 66, 392-397 (1992)
6. SHIMODA, K., YOSHIDA, M., WAGAI, N., TAKAYAMA, S. and KATO, M. Phototoxic lesions induced by quinolone antibacterial agents in auricular skin and retina of albino mice. Toxicologic Pathology 21(6) 554-561 (1993)