Effect of ginkgo biloba extract EGb 761 on differential gene expression in the brain

Nutrigenomics

Volumn , Issue , 2005, Pages 341-352

  Cermak, Rainer ^a   Wolffram, Siegfried ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 70549084619     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (51)

1. Holzl J. Die Zusammensetzung von Ginkgo biloba. Pharm Unserer Zeit 1992; 21:215-223.
2. Sticher O. Quality of Ginkgo preparations. Planta Med 1993; 59:2-11.
3. van Beek TA. Chemical analysis of Ginkgo biloba leaves and extracts. J Chromatogr A 2002; 967:21-55.
4. Tang Y, Lou F, Wang J, Li Y, Zhuang S. Coumaroyl flavonol glycosides from the leaves of Ginkgo biloba. Phytochemistry 2001; 58:1251-1256.
5. Bedir E, Tatli II, Khan RA, Zhao JP, Takamatsu S, Walker LA, Goldman P, Khan IA. Biologically active secondary metabolites from Ginkgo biloba. J Agric Food Chem 2002; 50:3150-3155.
6. Hecker H, Johannisson R, Koch E, Siegers CP. In vitro evaluation of the cytotoxic potential of alkylphenols from Ginkgo biloba L. Toxicology 2002; 177:167-177.
7. Kressmann S, Müller WE, Blume HH. Pharmaceutical quality of different Ginkgo biloba brands. J Pharm Pharmacol 2002; 54:661-669.
8. Kleijnen J, Knipschild PG. Ginkgo biloba for cerebral insufficiency. Br J Clin Pharmacol 1992; 34:352-358.
9. Oken BS, Storzbach DM, Kaye JA. The efficacy of Ginkgo biloba on cognitive function in Alzheimer disease. Arch Neurol 1998; 55:1409-1415.
10. Le Bars PL, Kastelan J. Efficacy and safety of a Ginkgo biloba extract. Public Health Nutr 2000; 3:495-499.
11. Le Bars PL, Katz MM, Berman N, Itil TM, Freedman AM, Schatzberg AF. A placebocontrolled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. J Am Med Assoc 1997; 278:1327-1332.
12. Kanowski S, Herrmann WM, Stephan K, Wierich W, Horr R. Proof of efficacy of the Ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia. Pharmacopsychiatry 1996; 29:47-56.
13. Oberpichler H, Sauer D, Rossberg C, Mennel HD, Krieglstein J. PAF antagonist ginkgolide B reduces postischemic neuronal damage in rat brain hippocampus. J Cereb Blood Flow Metab 1990; 10:133-135.
14. Smith PF, MacLennan KM, Darlington CL. The neuroprotective properties of the Ginkgo biloba leaf: a review of the possible relationship to platelet-activating factor (PAF). J Ethnopharmacol 1996; 50:131-139.
15. Xin W, Wei T, Chen C, Ni Y, Zhao B, Hou J. Mechanisms of apoptosis in rat cerebellar granule cells induced by hydroxyl radicals and the effects of EGb761 and its constituents. Toxicology 2000; 148:103-110.
16. Bastianetto S, Ramassamy C, Dore S, Christen Y, Poirier J, Quirion R. The Ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by 8-amyloid. Eur J Neurosci 2000; 12:1882-1890.
17. Bastianetto S, Zheng WH, Quirion R. The Ginkgo biloba extract (EGb 761) protects and rescues hippocampal cells against nitric oxide-induced toxicity: involvement of its flavonoid constituents and protein kinase C. J Neurochem 2000; 74:2268-2277.
18. Wei T, Ni Y, Hou J, Chen C, Zhao B, Xin W. Hydrogen peroxide-induced oxidative damage and apoptosis in cerebellar granule cells: protection by Ginkgo biloba extract. Pharmacol Res 2000; 41:427-433.
19. Scholtyssek H, Damerau W, Wessel R, Schimke I. Antioxidative activity of ginkgolides against superoxide in an aprotic environment. Chem Biol Interact 1997; 106:183-190.
20. Zhang WR, Hayashi T, Kitagawa H, Sasaki C, Sakai K, Warita H, Wang JM, Shiro Y, Uchida M, Abe K. Protective effect of Ginkgo extract on rat brain with transient middle cerebral artery occlusion. Neurol Res 2000; 22:517-521.
21. Clark WM, Rinker LG, Lessov NS, Lowery SL, Cipolla MJ. Efficacy of antioxidant therapies in transient focal ischemia in mice. Stroke 2001; 32:1000-1004.
22. Chandrasekaran K, Mehrabian Z, Spinnewyn B, Drieu K, Fiskum G. Neuroprotective effects of bilobalide, a component of the Ginkgo biloba extract (EGb 761), in gerbil global brain ischemia. Brain Res 2001; 922:282-292.
23. Unal I, Giirsoy-Ozdemir Y, Bolay H, Soylemezoglu F, Saribas O, Dalkara T. Chronic daily administration of selegiline and EGb 761 increases brain’s resistance to ischemia in mice. Brain Res 2002; 917:174-181.
24. DeFeudis FV, Drieu K. Ginkgo biloba extract (EGb 761) and CNS functions: basic studies and clinical applications. Curr Drug Targets 2000; 1:25-58.
25. Yoshikawa T, Naito Y, Kondo M. Ginkgo biloba leaf extract: review of biological actions and clinical applications. Antioxid Redox Signal 1999; 1:469-480.
26. MacLennan KM, Darlington CL, Smith PF. The CNS effects of Ginkgo biloba extracts and ginkgolide B. Prog Neurobiol 2002; 67:235-257.
27. Saliou C, Valacchi G, Rimbach G. Assessing bioflavonoids as regulators of NF-kB activity and inflammatory gene expression in mammalian cells. Methods Enzymol 2001; 335:380-387.
28. Rimbach G, Gohil K, Matsugo S, Moini H, Saliou C, Virgili F, Weber SU, Packer L. Induction of glutathione synthesis in human keratinocytes by Ginkgo biloba extract (EGb761). Biofactors 2001; 15:39-52.
29. Gagne B, Gelinas S, Bureau G, Lagace B, Ramassamy C, Chiasson K, Valastro B, Martinoli MG. Effects of estradiol, phytoestrogens, and Ginkgo biloba extracts against 1-methyl-4-phenyl-pyridine-induced oxidative stress. Endocrine 2003; 21:89-95.
30. Smith JV, Burdick AJ, Golik P, Khan I, Wallace D, Luo Y. Anti-apoptotic properties of Ginkgo biloba extract EGb 761 in differentiated PC12 cells. Cell Mol Biol (Noisy-le-grand) 2002; 48:699-707.
31. Tendi EA, Bosetti F, DasGupta SF, Stella AMG, Drieu K, Rapoport SI. Ginkgo biloba extracts EGb 761 and bilobalide increase NADH dehydrogenase mRNA level and mitochondrial respiratory control ratio in PC12 cells. Neurochem Res 2002; 27:319-323.
32. Chandrasekaran K, Liu LI, Hatanpaa K, Drieu K, Rapoport SI. Stimulation of mitochondrial gene expression by bilobalide, a component of Ginkgo biloba extract (EGb 761). In: Packer L, Christen Y, eds. Ginkgo biloba Extract: Lessons from Cell Biology. Paris: Elsevier, 1998:121-128.
33. Zhuan H, Pin S, Christen Y, Dore S. Induction of heme oxygenase 1 by Ginkgo biloba in neuronal cultures and potential implications in ischemia. Cell Mol Biol (Noisy-le-grand) 2002; 48:647-653.
34. Soulie C, Nicolle A, Christen Y, Ceballos-Picot I. The Ginkgo biloba extract EGb 761 increases viability of hNT human neurons in culture and affects the expression of genes implicated in the stress response. Cell Mol Biol (Noisy-le-grand) 2002; 48:641-646.
35. Wong A, Dukic-Stefanovic S, Gasic-Milenkovic J, Schinzel R, Wiesinger H, Riederer P, Munch G. Anti-inflammatory antioxidants attenuate the expression of inducible nitric oxide synthase mediated by advanced glycation endproducts in murine microglia. Eur J Neurosci 2001; 14:1961-1967.
36. Zheng SX, Zhou LJ, Chen ZL, Yin ML, Zhu XZ. Bilobalide promotes expression of glial cell line-derived neurotrophic factor and vascular endothelial growth factor in rat astrocytes. Acta Pharmacol Sin 2000; 21:151-155.
37. Lapchak PA, Gash DM, Collins F, Hilt D, Miller PJ, Araujo DM. Pharmacological activities of glial cell line-derived neurotrophic factor (GDNF): preclinical development and application to the treatment of Parkinson’s disease. Exp Neurol 1997; 145:309-321.
38. Gutmann H, Bruggisser R, Schaffner W, Bogman K, Botomino A, Drewe J. Transport of amentoflavone across the blood-brain barrier in vitro. Planta Med 2002; 68:804-807.
39. Youdim KA, Dobbie MS, Kuhnle GGC, Proteggente AR, Abbott NJ, Rice-Evans CA. Interaction between flavonoids and the blood -brain barrier: in vitro studies. J Neuro-chem 2003; 85:180-192.
40. Loffler T, Lee SK, Noldner M, Chatterjee SS, Hoyer S, Schliebs R. Effect of Ginkgo biloba extract (EGb761) on glucose metabolism-related markers in streptozotocin-damaged rat brain. J Neural Transm 2001; 108:1457-1474.
41. Didier A, Jourdan F. The Ginkgo biloba extract modulates the balance between proliferation and differentiation in the olfactory epithelium of adult mice following bulbectomy. Cell Mol Biol (Noisy-le-grand) 2002; 48:717-723.
42. Sharma HS, Drieu K, Alm P, Westman J. Role of nitric oxide in blood-brain barrier permeability, brain edema and cell damage following hyperthermic brain injury. An experimental study using EGb-761 and ginkgolide B pretreatment in the rat. Acta Neurochir 2000; 76:81-86.
43. Watanabe CMH, Wolffram S, Ader P, Rimbach G, Packer L, Maguire JJ, Schultz PG, Gohil K. The in vivo neuromodulatory effects of the herbal medicine Ginkgo biloba. Proc Natl Acad Sci USA 2001; 98:6577-6580.
44. Ader P, Wessmann S, Wolffram S. Bioavailability and metabolism of the flavonol quercetin in the pig. Free Radic Biol Med 2000; 28:1056-1067.
45. Cermak R, Landgraf S, Wolffram S. The bioavailability of quercetin in pigs depends on the glycoside moiety and on dietary factors. J Nutr 2003; 133:2802-2807.
46. Iqbal K, Alonso AC, Gong CX, Khatoon S, Pei JJ, Wang JZ, Grundke-Iqbal I. Mechanisms of neurofibrillary degeneration and the formation of neurofibrillary tangles. J Neural Transm 1998; 53(suppl):169-180.
47. Bennecib M, Gong CX, Grundke-Iqbal I, Iqbal K. Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain. FEBS Lett 2000; 485:87-93.
48. Gong CX, Lidsky T, Wegiel J, Zuck L, Grundke-Iqbal I, Iqbal K. Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. J Biol Chem 2000; 275:5535-5544.
49. Nyberg F. Growth hormone in the brain: characteristics of specific brain targets for the hormone and their functional significance. Front Neuroendocrinol 2000; 21:330-348.
50. Porterfield SP. Thyroidal dysfunction and environmental chemicals—potential impact on brain development. Environ Health Perspect 2000; 108:433-438.
51. Tsuzuki K, Fukatsu R, Yamaguchi H, Tateno M, Imai K, Fujii N, Yamauchi T. Transthyretin binds amyloid β-peptides, Ay81-42 and Ay81-40 to form complex in the autop-sied human kidney—possible role of transthyretin for Ab sequestration. Neurosci Lett 2000; 281:171-174.