Decomposition of 3′-azido-2′,3′-dideoxythymidine 5′-monophosphate (AZTMP) prodrugs in biological media studied by on-line solid-phase extraction coupled to liquid chromatography mass spectrometry

Biomedical Chromatography

Volumn 23, Issue 11, 2009, Pages 1160-1168

  Lefebvre, Isabelle ^a   Beltran, Thierry ^a   Peyrottes, Suzanne ^a   Périgaud, Christian ^a  

^a UNIVERSITÉ DE MONTPELLIER   (France)

Author keywords

LC MS; On line solid phase extraction; Prodrug; Zidovudine

Indexed keywords

BIOMOLECULES; COLUMN CHROMATOGRAPHY; EXTRACTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHASE SEPARATION;

BIOLOGICAL MEDIA; COLUMN-SWITCHING HPLC; HPLC METHOD; LC/MS; LIQUID CHROMATOGRAPHY - MASS SPECTROMETRIES; MONONUCLEOTIDES; ON-LINE SOLID PHASE EXTRACTION; PRODRUGS; PRONUCLEOTIDES; ZIDOVUDINE;

METABOLITES;

3' AZIDO 2',3' DIDEOXYTHYMIDINE 5' MONOPHOSPHATE; UNCLASSIFIED DRUG; ZIDOVUDINE; ZIDOVUDINE DERIVATIVE; 3' AZIDO 3' DEOXYTHYMIDINE 5'PHOSPHATE; 3'-AZIDO-3'-DEOXYTHYMIDINE 5'PHOSPHATE; BIOLOGICAL PRODUCT; DIDEOXYNUCLEOTIDE; DRUG DERIVATIVE; PRODRUG; PYRIMIDINE NUCLEOTIDE;

ANALYTIC METHOD; ANTIVIRAL ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DRUG DECOMPOSITION; DRUG DETERMINATION; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LIPOPHILICITY; METABOLITE; QUANTITATIVE STUDY; SOLID PHASE EXTRACTION; VIRUS REPLICATION; DRUG STABILITY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SOLUBILITY;

BIOLOGICAL PRODUCTS; CHROMATOGRAPHY, LIQUID; DIDEOXYNUCLEOTIDES; DRUG STABILITY; MASS SPECTROMETRY; PRODRUGS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; SOLUBILITY; THYMINE NUCLEOTIDES; ZIDOVUDINE;

EID: 70450270750     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1238     Document Type: Article

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