A slow ATP-induced conformational change limits the rate of DNA binding but not the rate of β clamp binding by the Escherichia coli γ complex clamp loader

Journal of Biological Chemistry

Volumn 284, Issue 46, 2009, Pages 32147-32157

  Thompson, Jennifer A ^a   Paschall, Christopher O ^a   O'Donnell, Mike ^b   Bloom, Linda B ^a,c  

^a UNIVERSITY OF FLORIDA   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c UNIVERSITY OF FLORIDA HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASSOCIATION RATE CONSTANTS; BINDING ASSAYS; CLAMP LOADER; CONFORMATIONAL CHANGE; DNA BINDING; DNA POLYMERASE; DNA SYNTHESISS; FLUORESCENCE INTENSITIES; PRE-INCUBATION; PROCESSIVITY; RATE LIMITING; REACTION CYCLES; TERNARY COMPLEX;

DNA; ESCHERICHIA COLI; FLUORESCENCE; GENES; LOADERS; LOADING; NUCLEIC ACIDS; RATE CONSTANTS;

COMPLEXATION;

ADENOSINE TRIPHOSPHATE; BACTERIAL PROTEIN; COMPLEX CLAMP LOADER; UNCLASSIFIED DRUG;

ARTICLE; BETA CHAIN; BINDING AFFINITY; BINDING ASSAY; BINDING KINETICS; CONTROLLED STUDY; ENZYME CONFORMATION; ESCHERICHIA COLI; FLUORESCENCE; GAMMA CHAIN; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN STRUCTURE;

ADENOSINE TRIPHOSPHATE; BINDING SITES; DNA POLYMERASE III; DNA REPLICATION; DNA, BACTERIAL; ESCHERICHIA COLI; KINETICS; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN SUBUNITS;

ESCHERICHIA COLI;

EID: 70450265205     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.045997     Document Type: Article

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