메뉴 건너뛰기




Volumn 34, Issue 10, 2009, Pages 554-564

Erlotinib (Tarceva) for the treatment of non-small-cell lung cancer and pancreatic cancer

Author keywords

EGFR mutation; Erlotinib; Non small cell lung cancer; Pancreatic cancer

Indexed keywords

CARBOPLATIN; CETUXIMAB; CISPLATIN; DOCETAXEL; ERLOTINIB; GEFITINIB; GEMCITABINE; PACLITAXEL; PANITUMUMAB; PEMETREXED; PLACEBO;

EID: 70450248381     PISSN: 10521372     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (32)

References (63)
  • 1
  • 2
    • 0034722889 scopus 로고    scopus 로고
    • The EGF receptor family as targets for cancer therapy
    • DOI 10.1038/sj.onc.1204082
    • Mendelsohn J, Baselga J. The EGF receptor family as targets for cancer therapy. Oncogene 2000;19(56):6550-6565. (Pubitemid 32197693)
    • (2000) Oncogene , vol.19 , Issue.56 , pp. 6550-6565
    • Mendelsohn, J.1    Baselga, J.2
  • 3
    • 22044445517 scopus 로고    scopus 로고
    • Erlotinib in previously treated non-small-cell lung cancer
    • Shepherd FA, Rodrigues Pereira J, et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 2005;353(2):123-132.
    • (2005) N Engl J Med , vol.353 , Issue.2 , pp. 123-132
    • Shepherd, F.A.1    Rodrigues Pereira, J.2
  • 5
    • 84869677953 scopus 로고    scopus 로고
    • Drugs@FDA. Available at: Accessed January 14, 2009
    • FDA. Drugs@FDA. Available at: www.accessdata.fda.gov/scripts/cder/ drugsatfda/index.cfm?fuseaction=Search.DrugDetails. Accessed January 14, 2009.
  • 6
    • 84869688064 scopus 로고    scopus 로고
    • Available at Accessed January 13, 2009
    • National Comprehensive Cancer Network (NCCN). Drugs & Biologics Compendium. Available at www.nccn.org/professionals/drug-compendium/content/ contents.asp. Accessed January 13, 2009.
    • Drugs & Biologics Compendium
  • 7
    • 0041435762 scopus 로고    scopus 로고
    • Available at: Accessed May 23, 2009
    • American Cancer Society. Cancer facts and figures 2009. Available at: www.cancer.org/downloads/STT/500809web.pdf. Accessed May 23, 2009.
    • Cancer Facts and Figures 2009
  • 8
    • 33947498978 scopus 로고    scopus 로고
    • Molecular predictors of response to epidermal growth factor receptor antagonists in non-small-cell lung cancer
    • DOI 10.1200/JCO.2006.07.3585
    • Sequist LV, Bell DW, Lynch TJ, Haber DA. Molecular predictors of response to epidermal growth factor receptor antagonists in non-small-cell lung cancer. J Clin Oncol 2007;25(5):587-595. (Pubitemid 350002967)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.5 , pp. 587-595
    • Sequist, L.V.1    Bell, D.W.2    Lynch, T.J.3    Haber, D.A.4
  • 9
    • 51649120733 scopus 로고    scopus 로고
    • KRAS status and efficacy in the first-line treatment of patients with metastatic colorectal cancer (mCRC) treated with FOLFIRI with or without cetuximab: The CRYSTAL experience
    • Abstract 2
    • Van Cutsem E, Lang I, D'haens G, et al. KRAS status and efficacy in the first-line treatment of patients with metastatic colorectal cancer (mCRC) treated with FOLFIRI with or without cetuximab: The CRYSTAL experience (Abstract 2). J Clin Oncol 2008;26(May 20 Suppl).
    • (2008) J Clin Oncol , vol.26 , Issue.MAY 20 SUPPL.
    • Van Cutsem, E.1    Lang, I.2    D'haens, G.3
  • 10
    • 54949085398 scopus 로고    scopus 로고
    • K-ras mutations and benefit from cetuximab in advanced colorectal cancer
    • Karapetis CS, Khambata-Ford S, Jonker DJ, et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 2008;359(17):1757-1765.
    • (2008) N Engl J Med , vol.359 , Issue.17 , pp. 1757-1765
    • Karapetis, C.S.1    Khambata-Ford, S.2    Jonker, D.J.3
  • 12
    • 64049086849 scopus 로고    scopus 로고
    • Impact of EGFR and KRAS genotype on outcomes in a clinical trial registry of NSCLC patients initially treated with erlotinib or gefitinib
    • Abstract 8035
    • Jackman DM, Sequist LV, Cioffredi L, et al. Impact of EGFR and KRAS genotype on outcomes in a clinical trial registry of NSCLC patients initially treated with erlotinib or gefitinib (Abstract 8035). J Clin Oncol 2008;26(May 20 Suppl).
    • (2008) J Clin Oncol , vol.26 , Issue.MAY 20 SUPPL.
    • Jackman, D.M.1    Sequist, L.V.2    Cioffredi, L.3
  • 13
    • 27544503230 scopus 로고    scopus 로고
    • Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
    • DOI 10.1016/S0140-6736(05)67625-8, PII S0140673605676258
    • Thatcher N, Chang A, Parikh P, et aL Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet 2005;366(9496):1527-1537. (Pubitemid 41540110)
    • (2005) Lancet , vol.366 , Issue.9496 , pp. 1527-1537
    • Thatcher, N.1    Chang, A.2    Parikh, P.3    Pereira, J.R.4    Ciuleanu, T.5    Von Pawel, J.6    Thongprasert, S.7    Tan, E.H.8    Pemberton, K.9    Archer, V.10    Carroll, K.11
  • 17
    • 33745645399 scopus 로고    scopus 로고
    • Salvage therapy for advanced non-small cell lung cancer: Factors influencing treatment selection
    • DOI 10.1634/theoncologist.11-6-655
    • Ramalingam S, Sandler AB. Salvage therapy for advanced non-small cell lung cancer: Factors influencing treatment selection. Oncologist 2006;11(6):655-665. (Pubitemid 43967620)
    • (2006) Oncologist , vol.11 , Issue.6 , pp. 655-665
    • Ramalingam, S.1    Sandler, A.B.2
  • 18
    • 33745928129 scopus 로고    scopus 로고
    • Smoking history and epidermal growth factor receptor expression as predictors of survival benefit from erlotinib for patients with non-small-cell lung cancer in the National Cancer Institute of Canada Clinical Trials Group Study br.21
    • Clark GM, Zborowski DM, Santabarbara P, et al. Smoking history and epidermal growth factor receptor expression as predictors of survival benefit from erlotinib for patients with non-small-cell lung cancer in the National Cancer Institute of Canada Clinical Trials Group study BR.21. Clin Lung Cancer 2006;7(6):389-394. (Pubitemid 44043548)
    • (2006) Clinical Lung Cancer , vol.7 , Issue.6 , pp. 389-394
    • Clark, G.M.1    Zborowski, D.M.2    Santabarbara, P.3    Ding, K.4    Whitehead, M.5    Seymour, L.6    Shepherd, F.A.7
  • 20
    • 66749127822 scopus 로고    scopus 로고
    • The global TRUST study of erlotinib in advanced non-small-cell lung cancer (NSCLC)
    • Abstract 19000
    • Groen H, Arrieta OG, Riska H, et al. The global TRUST study of erlotinib in advanced non-small-cell lung cancer (NSCLC) (Abstract 19000). J Clin Oncol 2008;26(May 20 Suppl).
    • (2008) J Clin Oncol , vol.26 , Issue.MAY 20 SUPPL.
    • Groen, H.1    Arrieta, O.G.2    Riska, H.3
  • 23
    • 34447129570 scopus 로고    scopus 로고
    • Correlation between development of rash and efficacy in patients treated with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib in two large phase III studies
    • DOI 10.1158/1078-0432.CCR-06-2610
    • Wacker B, Nagrani T, Weinberg J, et al. Correlation between development of rash and efficacy in patients treated with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib in two large phase III studies. Clin Cancer Res 2007;13(13):3913-3921. (Pubitemid 47037599)
    • (2007) Clinical Cancer Research , vol.13 , Issue.13 , pp. 3913-3921
    • Wacker, B.1    Nagrani, T.2    Weinberg, J.3    Witt, K.4    Clark, G.5    Cagnoni, P.J.6
  • 24
    • 70450277975 scopus 로고    scopus 로고
    • May Available at Accessed June 11, 2009
    • FDA. Tarceva (erlotinib), May 2009. Available at www.fda.gov/Safety/ MedWatch/Safetylnformation/SafetyAlertsforHumanMedicalProducts/ucm150596.htm. Accessed June 11, 2009.
    • (2009) Tarceva (Erlotinib)
  • 25
    • 46049114551 scopus 로고    scopus 로고
    • Final survival and safety results from a multicenter, open-label, phase 3b trial of erlotinib in patients with advanced nonsmall cell lung cancer
    • DOI 10.1002/cncr.23490
    • Spigel DR, Lin M, O'Neill V, Hainsworth JD. Final survival and safety results from a multicenter, open-label, phase 3b trial of erlotinib in patients with advanced non-small cell lung cancer. Cancer 2008;112(12):2749-2755. (Pubitemid 351969220)
    • (2008) Cancer , vol.112 , Issue.12 , pp. 2749-2755
    • Spigel, D.R.1    Lin, M.2    O'Neill, V.3    Hainsworth, J.D.4
  • 26
    • 67650996763 scopus 로고    scopus 로고
    • Efficacy of erlotinib in patients with advanced non-small-cell lung cancer relative to clinical characteristics: Subset analyses from the TRUST study
    • Abstract 8081
    • Allan S, Bosquee L, Franke A, et al. Efficacy of erlotinib in patients with advanced non-small-cell lung cancer relative to clinical characteristics: Subset analyses from the TRUST study (Abstract 8081). J Clin Oncol 2008;26(May 20 Suppl):444s.
    • (2008) J Clin Oncol , vol.26 , Issue.MAY 20 SUPPL.
    • Allan, S.1    Bosquee, L.2    Franke, A.3
  • 27
    • 84869667202 scopus 로고    scopus 로고
    • Second-line erlotinib in patients with advanced non-small-cell lung cancer: Results from a large, open-label study
    • Abstract 19002
    • Crinò L, Moyer M, Eberhardt W, et al. Second-line erlotinib in patients with advanced non-small-cell lung cancer: Results from a large, open-label study (Abstract 19002). J Clin Oncol 2008;26 (May 20 Suppl):706s.
    • (2008) J Clin Oncol , vol.26 , Issue.MAY 20 SUPPL.
    • Crinò, L.1    Moyer, M.2    Eberhardt, W.3
  • 31
    • 59649106861 scopus 로고    scopus 로고
    • The risk of febrile neutropenia in patients with non-small-cell lung cancer treated with docetaxel: A systematic review and meta-analysis
    • Wailoo A, Sutton A, Morgan A. The risk of febrile neutropenia in patients with non-small-cell lung cancer treated with docetaxel: A systematic review and meta-analysis. Br J Cancer 2009;100(3): 436-441.
    • (2009) Br J Cancer , vol.100 , Issue.3 , pp. 436-441
    • Wailoo, A.1    Sutton, A.2    Morgan, A.3
  • 34
    • 37549072095 scopus 로고    scopus 로고
    • V.2. Available at: Accessed January 13, 2009
    • National Comprehensive Cancer Network (NCCN). Clinical Practice Guidelines in Oncology: Non-Small Cell Lung Cancer, V.2.2009. Available at: www.nccn.org/professionals/physician-gls/PDF/nscl.pdf. Accessed January 13, 2009.
    • (2009) Clinical Practice Guidelines in Oncology: Non-Small Cell Lung Cancer
  • 35
    • 52049090365 scopus 로고    scopus 로고
    • Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group study BR.21
    • Zhu CQ, da Cunha Santos G, Ding K, et al. Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group study BR.21. J Clin Oncol 2008;26(26):4268-4275.
    • (2008) J Clin Oncol , vol.26 , Issue.26 , pp. 4268-4275
    • Zhu, C.Q.1    Da Cunha Santos, G.2    Ding, K.3
  • 36
    • 70450281708 scopus 로고    scopus 로고
    • Biomarker status correlates with clinical benefit: Phase 2 study of single-agent erlotinib (E) or e intercalated with carboplatin and paclitaxel (ECP) in an EGFR biomarker-selected NSCLC population
    • Abstract 11
    • Hirsch FR, Dziadziuszko R, Camidge DR, et al. Biomarker status correlates with clinical benefit: Phase 2 study of single-agent erlotinib (E) or E intercalated with carboplatin and paclitaxel (ECP) in an EGFR biomarker-selected NSCLC population (Abstract 11). J Thorac Oncol 2008;3(Suppl 4):S263-S305.
    • (2008) J Thorac Oncol , vol.3 , Issue.SUPPL. 4
    • Hirsch, F.R.1    Dziadziuszko, R.2    Camidge, D.R.3
  • 40
    • 27244443759 scopus 로고    scopus 로고
    • Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: A southwest oncology group study
    • DOI 10.1200/JCO.2005.01.2823
    • Hirsch FR, Varella-Garcia M, McCoy J, et al. Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: A Southwest Oncology Group study. J Clin Oncol 2005; 23(28):6838-6845. (Pubitemid 46260270)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.28 , pp. 6838-6845
    • Hirsch, F.R.1    Varella-Garcia, M.2    McCoy, J.3    West, H.4    Xavier, A.C.5    Gumerlock, P.6    Bunn Jr., P.A.7    Franklin, W.A.8    Crowley, J.9    Gandara, D.R.10
  • 41
    • 62549097885 scopus 로고    scopus 로고
    • Gefitinib (g) vs. carboplatin/paclitaxel (c/p) in clinically selected chemonaïve patients with advanced non-small-cell lung cancer (NSCLC) in Asia (IPASS): Randomized, open-label, phase III study
    • Abstract
    • Mok TS, Leong S, Liu X, et al. Gefitinib (g) vs. carboplatin/paclitaxel (c/p) in clinically selected chemonaïve patients with advanced non-small-cell lung cancer (NSCLC) in Asia (IPASS): Randomized, open-label, phase III study (Abstract). J Thorac Oncol 2008;3(11 Suppl 4):S263-S305.
    • (2008) J Thorac Oncol , vol.3 , Issue.11 SUPPL. 4
    • Mok, T.S.1    Leong, S.2    Liu, X.3
  • 42
    • 34548626275 scopus 로고    scopus 로고
    • Evaluation of erlotinib in advanced non-small cell lung cancer: Impact on the budget of a U.S. health insurance plan
    • Ramsey SD, Clarke L, Kamath TV, Lubeck D. Evaluation of erlotinib in advanced non-small cell lung cancer: Impact on the budget of a U.S. health insurance plan. J Manag Care Pharm 2006;12(6):472-478. (Pubitemid 47400588)
    • (2006) Journal of Managed Care Pharmacy , vol.12 , Issue.6 , pp. 473-478
    • Ramsey, S.D.1    Clarke, L.2    Kamath, T.V.3    Lubeck, D.4
  • 43
    • 50849117805 scopus 로고    scopus 로고
    • Comparative clinical and economic outcomes of treatments for refractory non-small cell lung cancer (NSCLC)
    • Carlson JJ, Reyes C, Oestreicher N, et al Comparative clinical and economic outcomes of treatments for refractory non-small cell lung cancer (NSCLC). Lung Cancer 2008;61(3):405-415.
    • (2008) Lung Cancer , vol.61 , Issue.3 , pp. 405-415
    • Carlson, J.J.1    Reyes, C.2    Oestreicher, N.3
  • 45
    • 33646568784 scopus 로고    scopus 로고
    • Patterns of cancer incidence, mortality, and prevalence across five continents: Defining priorities to reduce cancer disparities in different geographic regions of the world
    • DOI 10.1200/JCO.2005.05.2308
    • Kamangar F, Dores GM, Anderson WF. Patterns of cancer incidence, mortality, and prevalence across five continents: Defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol 2006;24(14):2137-2150. (Pubitemid 46655601)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.14 , pp. 2137-2150
    • Kamangar, F.1    Dores, G.M.2    Anderson, W.F.3
  • 48
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
    • Burris HA 3rd, Moore MJ, Andersen J, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial. J Clin Oncol 1997;15(6):2403-2413.
    • (1997) J Clin Oncol , vol.15 , Issue.6 , pp. 2403-2413
    • Burris III, H.A.1    Moore, M.J.2    Andersen, J.3
  • 49
    • 43549094700 scopus 로고    scopus 로고
    • New therapeutic directions for advanced pancreatic cancer: Targeting the epidermal growth factor and vascular endothelial growth factor pathways
    • Burris H 3rd, Rocha-Lima C. New therapeutic directions for advanced pancreatic cancer: Targeting the epidermal growth factor and vascular endothelial growth factor pathways. Oncologist 2008;13(3):289-298.
    • (2008) Oncologist , vol.13 , Issue.3 , pp. 289-298
    • Burris III, H.1    Rocha-Lima, C.2
  • 50
    • 0036682041 scopus 로고    scopus 로고
    • Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group trial E2297
    • DOI 10.1200/JCO.2002.11.149
    • Berlin JD, Catalano P, Thomas JP, et al. Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297. J Clin Oncol 2002; 20(15):3270-3275. (Pubitemid 34831525)
    • (2002) Journal of Clinical Oncology , vol.20 , Issue.15 , pp. 3270-3275
    • Berlin, J.D.1    Catalano, P.2    Thomas, J.P.3    Kugler, J.W.4    Haller, D.G.5    Benson III, A.B.6
  • 51
    • 34249738700 scopus 로고    scopus 로고
    • Rash as a surrogate marker for efficacy of epidermal growth factor receptor inhibitors in lung cancer
    • Perez-Soler R. Rash as a surrogate marker for efficacy of epidermal growth factor receptor inhibitors in lung cancer. Clin Lung Cancer 2006;8(Suppl 1):S7-S14.
    • (2006) Clin Lung Cancer , vol.8 , Issue.SUPPL. 1
    • Perez-Soler, R.1
  • 52
    • 0001412078 scopus 로고    scopus 로고
    • Acne-like rash predicts response in patients treated with cetuximab (IMC-225) plus irinotecan (CPT-11) in CPT-11 refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR)
    • Abstract 559
    • Saltz L, Rubin MS, Hochster H et al. Acne-like rash predicts response in patients treated with cetuximab (IMC-225) plus irinotecan (CPT-11) in CPT-11 refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR) (Abstract 559). Clin Cancer Res 2001;7:3766s.
    • (2001) Clin Cancer Res , vol.7
    • Saltz, L.1    Rubin, M.S.2    Hochster, H.3
  • 53
    • 43749091034 scopus 로고    scopus 로고
    • Budget impact model of adding erlotinib to a regimen of gemcitabine for the treatment of locally advanced, nonresectable or metastatic pancreatic cancer
    • DOI 10.1016/j.clinthera.2008.04.016, PII S0149291808001550
    • Danese MD, Reyes C, Northridge K, et al. Budget impact model of adding erlotinib to a regimen of gemcitabine for the treatment of locally advanced nonresectable or metastatic pancreatic cancer. Clin Ther 2008;30(4):775-784. (Pubitemid 351689042)
    • (2008) Clinical Therapeutics , vol.30 , Issue.4 , pp. 775-784
    • Danese, M.D.1    Reyes, C.2    Northridge, K.3    Lubeck, D.4    Lin, C.-Y.5    O'Connor, P.6
  • 54
    • 70349475409 scopus 로고    scopus 로고
    • SATURN: A double-blind, randomized, phase III study of maintenance erlotinib versus placebo following nonprogression with first-line platinum-based chemotherapy in patients with advanced NSCLC
    • Abstract 8001
    • Cappuzzo F, Ciuleanu T, Stelmakh L, et al. SATURN: A double-blind, randomized, phase III study of maintenance erlotinib versus placebo following nonprogression with first-line platinum-based chemotherapy in patients with advanced NSCLC (Abstract 8001). J Clin Oncol 2009;27(Suppl):15s.
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL.
    • Cappuzzo, F.1    Ciuleanu, T.2    Stelmakh, L.3
  • 55
    • 84869672253 scopus 로고    scopus 로고
    • National Institutes of Health. ClinicalTrials.gov. Available at Accessed January 13, 2009
    • National Institutes of Health. ClinicalTrials.gov. Available at www.clinicaltrials.gov. Accessed January 13, 2009.
  • 56
    • 2442523996 scopus 로고    scopus 로고
    • Enhanced cytotoxicity of docetaxel OSI-774 combination in non-small cell lung carcinoma (NSCLC)
    • Abstract 2661
    • Gumerlock PH, Pryde BJ, Kimura T, et al. Enhanced cytotoxicity of docetaxel OSI-774 combination in non-small cell lung carcinoma (NSCLC) (Abstract 2661). J Clin Oncol 2003;22(May 20 Suppl).
    • (2003) J Clin Oncol , vol.22 , Issue.MAY 20 SUPPL.
    • Gumerlock, P.H.1    Pryde, B.J.2    Kimura, T.3
  • 57
    • 16344392867 scopus 로고    scopus 로고
    • Pulsatile administration of the epidermal growth factor receptor inhibitor gefitinib is significantly more effective than continuous dosing for sensitizing tumors to paclitaxel
    • DOI 10.1158/1078-0432.CCR-04-1347
    • Solit DB, She Y, Lobo J, et al. Pulsatile administration of the epidermal growth factor receptor inhibitor gefitinib is significantly more effective than continuous dosing for sensitizing tumors to paclitaxel. Clin Cancer Res 2005;11(5):1983-1989. (Pubitemid 40471864)
    • (2005) Clinical Cancer Research , vol.11 , Issue.5 , pp. 1983-1989
    • Solit, D.B.1    She, Y.2    Lobo, J.3    Kris, M.G.4    Scher, H.I.5    Rosen, N.6    Sirotnak, F.M.7
  • 58
    • 56349142373 scopus 로고    scopus 로고
    • FAST-ACT: A phase II randomized double-blind trial of sequential erlotinib and chemotherapy as 1st-line treatment in patients with stage IIIB/IV non-small cell lung cancer
    • Abstract 8031
    • Lee J-S, Ignacio J, Yu C-J, et al. FAST-ACT: A phase II randomized double-blind trial of sequential erlotinib and chemotherapy as 1st-line treatment in patients with stage IIIB/IV non-small cell lung cancer (Abstract 8031). J Clin Oncol 2008;26(May 20 Suppl).
    • (2008) J Clin Oncol , vol.26 , Issue.MAY 20 SUPPL.
    • Lee, J.-S.1    Ignacio, J.2    Yu, C.-J.3
  • 59
    • 84869671654 scopus 로고    scopus 로고
    • Lung cancer and erlotinib: Which patients benefit?
    • (October 21, 2008). Available at Accessed January 16, 2009
    • Winstead ER. Lung cancer and erlotinib: Which patients benefit? NCI Cancer Bull, 2008;5 (October 21, 2008). Available at www.cancer.gov/ ncicancerbulletin/NCI-Cancer-Bulletin-102108/page6. Accessed January 16, 2009.
    • (2008) NCI Cancer Bull , vol.5
    • Winstead, E.R.1
  • 60
    • 65649132497 scopus 로고    scopus 로고
    • A phase III, multicenter, placebo-controlled, double-blind, randomized clinical trial to evaluate the efficacy of bevacizumab (Avastin) in combination with erlotinib (Tarceva) compared with erlotinib alone for treatment of advanced non-small cell lung cancer after failure of standard first-line chemotherapy (BETA)
    • Abstract
    • Hainsworth J, Herbst R. A phase III, multicenter, placebo-controlled, double-blind, randomized clinical trial to evaluate the efficacy of bevacizumab (Avastin) in combination with erlotinib (Tarceva) compared with erlotinib alone for treatment of advanced non-small cell lung cancer after failure of standard first-line chemotherapy (BETA) (Abstract). J Thorac Oncol 2008;3(11 Suppl 4):S263-S305.
    • (2008) J Thorac Oncol , vol.3 , Issue.11 SUPPL. 4
    • Hainsworth, J.1    Herbst, R.2
  • 61
    • 70349477817 scopus 로고    scopus 로고
    • A randomized double-blind, placebo-controlled, phase III trial (ATLAS) comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy with B for first-line treatment of locally advanced recurrent, or metastatic non-small cell lung cancer (NSCLC)
    • Abstract LBA8002
    • Miller VA, O'Connor P, Soh C, et al. A randomized double-blind, placebo-controlled, phase III trial (ATLAS) comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy with B for first-line treatment of locally advanced recurrent, or metastatic non-small cell lung cancer (NSCLC) (Abstract LBA8002). J Clin Oncol 2009;27(Suppl):18s.
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL.
    • Miller, V.A.1    O'Connor, P.2    Soh, C.3
  • 62
    • 37849044904 scopus 로고    scopus 로고
    • A phase I study of erlotinib in combination with gemcitabine and radiation in locally advanced, non-operable pancreatic adenocarcinoma
    • Duffy A, Kortmansky J, Schwartz GK, et al. A phase I study of erlotinib in combination with gemcitabine and radiation in locally advanced, non-operable pancreatic adenocarcinoma. Ann Oncol 2008;19(1):86-91.
    • (2008) Ann Oncol , vol.19 , Issue.1 , pp. 86-91
    • Duffy, A.1    Kortmansky, J.2    Schwartz, G.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.