A promiscuous conformational switch in the secondary multidrug transporter MdfA

Journal of Biological Chemistry

Volumn 284, Issue 47, 2009, Pages 32296-32304

  Fluman, Nir ^a   Cohen Karni, Devora ^a   Weiss, Tali ^a   Bibi, Eitan ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE TRANSPORT; BINDING POCKETS; CONFORMATIONAL BEHAVIOR; CONFORMATIONAL CHANGE; CONFORMATIONAL RESPONSE; CONFORMATIONAL SWITCHES; DIFFERENT SUBSTRATES; MEMBRANE PROTEINS; MULTIDRUG TRANSPORTERS; TOXIC COMPOUNDS;

BINDING ENERGY; BINDING SITES; ESCHERICHIA COLI; PROTEINS;

SUBSTRATES;

GLYCOPROTEIN P;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; COVALENT BOND; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; PROTEIN TRANSPORT; STRUCTURE ANALYSIS;

BINDING SITES; BIOLOGICAL TRANSPORT; CELL MEMBRANE; DETERGENTS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ENDOPEPTIDASE K; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MALEIMIDES; MEMBRANE TRANSPORT PROTEINS; MODELS, CHEMICAL; MOLECULAR CONFORMATION; POLYETHYLENE GLYCOLS; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

ESCHERICHIA COLI;

EID: 70450240786     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.050658     Document Type: Article

References (36)

1. Higgins, C. F. (2007) Nature 446, 749-757
2. Saier, M. H., Jr., and Paulsen, I. T. (2001) Semin. Cell Dev. Biol. 12, 205-213
3. Fluman, N., and Bibi, E. (2009) Biochim. Biophys. Acta 1794, 738-747
4. Venter, H., Shahi, S., Balakrishnan, L., Velamakanni, S., Bapna, A., Woebking, B., and van Veen, H. W. (2005) Biochem. Soc. Trans. 33, 1008-1011
5. Ambudkar, S. V., Lelong, I. H., Zhang, J., Cardarelli, C. O., Gottesman, M. M., and Pastan, I. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 8472-8476
6. Adler, J., and Bibi, E. (2004) J. Biol. Chem. 279, 8957-8965
7. Sigal, N., Cohen-Karni, D., Siemion, S., and Bibi, E. (2006) J. Mol. Microbiol. Biotechnol. 11, 308-317
8. Saier, M. H., Jr., Beatty, J. T., Goffeau, A., Harley, K. T., Heijne, W. H., Huang, S. C., Jack, D. L., Jähn, P. S., Lew, K., Liu, J., Pao, S. S., Paulsen, I. T., Tseng, T. T., and Virk, P. S. (1999) J. Mol. Microbiol. Biotechnol. 1, 257-279
9. Lewinson, O., and Bibi, E. (2001) Biochemistry 40, 12612-12618
10. Kubista, M., Sjoback, R., Eriksson, S., and Albinsson, B. (1994) Analyst 119, 417-419
11. Sigal, N., Vardy, E., Molshanski-Mor, S., Eitan, A., Pilpel, Y., Schuldiner, S., and Bibi, E. (2005) Biochemistry 44, 14870-14880
12. Kosower, E. M., and Kosower, N. S. (1995) Methods Enzymol. 251, 133-148
13. Dunham, T. D., and Farrens, D. L. (1999) J. Biol. Chem. 274, 1683-1690
14. Adler, J., Lewinson, O., and Bibi, E. (2004) Biochemistry 43, 518-525
15. Edgar, R., and Bibi, E. (1999) EMBO J. 18, 822-832
16. Adler, J., and Bibi, E. (2005) J. Biol. Chem. 280, 2721-2729
17. Adler, J., and Bibi, E. (2002) J. Bacteriol. 184, 3313-3320
18. Mitchell, B. A., Paulsen, I. T., Brown, M. H., and Skurray, R. A. (1999) J. Biol. Chem. 274, 3541-3548
19. Loo, T. W., Bartlett, M. C., and Clarke, D. M. (2003) J. Biol. Chem. 278, 39706-39710
20. Neyfakh, A. A. (2002) Mol. Microbiol. 44, 1123-1130
21. Vazquez-Laslop, N., Zheleznova, E. E., Markham, P. N., Brennan, R. G., and Neyfakh, A. A. (2000) Biochem. Soc. Trans. 28, 517-520
22. Nagano, K., and Nikaido, H. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 5854-5858
23. Cole, S. P., and Deeley, R. G. (2006) Trends. Pharmacol. Sci. 27, 438-446
24. Mao, Q., Deeley, R. G., and Cole, S. P. (2000) J. Biol. Chem. 275, 34166-34172
25. Bolhuis, H., van Veen, H. W., Brands, J. R., Putman, M., Poolman, B., Driessen, A. J., and Konings, W. N. (1996) J. Biol. Chem. 271, 24123-24128
26. Bolhuis, H., van Veen, H. W., Molenaar, D., Poolman, B., Driessen, A. J., and Konings, W. N. (1996) EMBO J. 15, 4239-4245
27. Loo, T. W., and Clarke, D. M. (1997) J. Biol. Chem. 272, 709-712
28. Loo, T. W., and Clarke, D. M. (1998) J. Biol. Chem. 273, 14671-14674
29. Loo, T. W., Bartlett, M. C., and Clarke, D. M. (2006) J. Biol. Chem. 281, 29436-29440
30. Loo, T. W., Bartlett, M. C., and Clarke, D. M. (2007) J. Biol. Chem. 282, 32043-32052
31. Loo, T. W., Bartlett, M. C., and Clarke, D. M. (2008) J. Biol. Chem. 283, 24860-24870
32. Loo, T. W., Bartlett, M. C., and Clarke, D. M. (2009) J. Biol. Chem. 284, 24074-24087
33. Smirnova, I., Kasho, V., Choe, J. Y., Altenbach, C., Hubbell, W. L., and Kaback, H. R. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 16504-16509
34. Hollenstein, K., Dawson, R. J., and Locher, K. P. (2007) Curr. Opin. Struct. Biol. 17, 412-418
35. Toyoshima, C. (2008) Arch. Biochem. Biophys. 476, 3-11
36. Edgar, R., and Bibi, E. (1997) J. Bacteriol. 179, 2274-2280