Loss of heterozygosity at 1p-19q induces a global change in oligodendroglial tumor gene expression

Journal of Neuro-Oncology

Volumn 95, Issue 3, 2009, Pages 343-354

  Ferrer Luna, Rubén ^a   Mata, Manuel ^b   Núñez, Lina ^c   Calvar, Jorge ^c   Dasí, Francisco ^d   Arias, Eugenia ^c   Piquer, José ^e   Cerdá Nicolás, Miguel ^a   Taratuto, Ana Lía ^c   Sevlever, Gustavo ^c   Celda, Bernardo ^a   Martinetto, Horacio ^f  

^a UNIVERSITY OF VALENCIA   (Spain)

^b HOSPITAL GENERAL UNIVERSITARIO DE VALENCIA   (Spain)

^c FLENI   (Argentina)

^d HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^e HOSPITAL DE LA RIBERA   (Spain)

^f INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Genomic alterations; Loss of heterozygosity; Microarray; Oligodendroglial tumors

Indexed keywords

ARF PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; EPIDERMAL GROWTH FACTOR RECEPTOR; NOTCH2 RECEPTOR; PROTEIN P53; RNA;

ADOLESCENT; ADULT; AGED; ARTICLE; ASTROCYTOMA; CANCER TISSUE; CELL MIGRATION; CELL PROLIFERATION; CHILD; CHROMOSOME 19Q; CHROMOSOME 1P; CLINICAL ARTICLE; GENE AMPLIFICATION; GENE DELETION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC ANALYSIS; GENOME; GLIOMA; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; INFLAMMATION; MICROARRAY ANALYSIS; NERVOUS SYSTEM DEVELOPMENT; OLIGODENDROGLIOMA; PRESCHOOL CHILD; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; TRISOMY;

ADOLESCENT; ADULT; AGED; BRAIN NEOPLASMS; CHILD, PRESCHOOL; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 1; CHROMOSOMES, HUMAN, PAIR 19; CLUSTER ANALYSIS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LOSS OF HETEROZYGOSITY; MIDDLE AGED; OLIGODENDROGLIOMA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 70450225464     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-009-9944-y     Document Type: Article

References (32)

1. Louis D, Ohgaki H, Wiestler O, Cavenee W (eds) (2007) World Health Organization classification of tumors of the nervous system. IARC/WHO, Lyon, pp 13-67
2. S Coons P Johnson B Scheithauer A Yates D Pearl 1997 Improving diagnostic accuracy and interobserver concordance in the classification and grading of primary gliomas Cancer 79 1381 1393 10.1002/(SICI)1097-0142(19970401)79: 7<1381::AID-CNCR16>3.0.CO;2-W 9083161 (Pubitemid 27143246)
3. J Cairncross D Macdonald 1988 Successful chemotherapy for recurrent malignat oligodendroglioma Ann Neurol 23 360 364 10.1002/ana.410230408 3382171
4. D Macdonald L Gaspar J Cairncross 1990 Successful chemotherapy for newly diagnosed aggressive oligodendroglioma Ann Neurol 27 573 574 10.1002/ana.410270519 2360797
5. G Reifenberger D Louis 2003 Oligodendroglioma: toward molecular definitions in diagnostic neuro-oncology J Neuropathol Exp Neurol 62 111 126 12578221
6. J Cairncross K Ueki M Zlatescu D Lisle D Finkelstein R Hammond J Silver P Stark D Macdonald D Ramsay D Louis 1998 Specific genetic predictors of chemoterapeutic response and survival in patients with anaplastic oligodendrogliomas J Natl Cancer Inst (Bethesda) 90 1473 1478 10.1093/jnci/90.19.1473
7. J Smith A Perry T Borel H Lee J O'Fallon S Hosek D Kimmel A Yates P Burger B Scheithauer R Jenkins 2000 Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas, and mixed oligosatrocytomas J Clin Oncol 18 636 645 10653879
8. C Griffin P Burger L Morsberger R Yonescu S Swierczynski J Weingart K Murphy 2006 Identification of der(1;19)(q10;p10) in five oligodendrogliomas suggests mechanism of concurrent 1p and 19q loss J Neuropathol Exp Neurol 65 988 994 10.1097/01.jnen.0000235122.98052.8f 17021403 (Pubitemid 44521799)
9. M Watson A Perry V Budhjara C Hicks W Shannon K Rich 2001 Gene expression profiling with oligonucleotides microarrays distinguish WHO grade of oligodendrogliomas Cancer Res 61 1825 1829 11280731
10. C Nutt D Mani R Betensky P Tamayo J Cairncross C Ladd U Pohl C Hatmann M McLauglin T Batchelor P Black A von Deimling S Pomeroy T Golub D Louis 2003 Gene expression based classification of malignant gliomas correlates better with survival than histological classification Cancer Res 63 1602 1607 12670911
11. P French S Swagemakers J Nagel M Kouwenhoven E Brouwer P van der Spek T Luider J Kros M van den Bent P Sillevis Smitt 2005 Gene expression profiles associated with treatment response in oligodendrogliomas Cancer Res 65 11335 11344 10.1158/0008-5472.CAN-05-1886 16357140 (Pubitemid 41821690)
12. B Tews J Felsberg C Hartmann A Kunitz M Hahn G Toedt K Neben L Hummerich A von Deimling G Reifenberger P Lichter 2006 Identification of novel oligodendroglioma-associated candidate tumor supressor genes in 1p36 and 19q13 using microarrays-based expression profiling Int J Cancer 119 792 800 10.1002/ijc.21901 16550607 (Pubitemid 44051441)
13. A Mukasa K Ueki S Matsumoto S Tsutsumi R Nishikawa T Fujimaki A Asai T Kirino H Aburatani 2002 Distinction in gene expression profile of oligodendrogliomas with and without allelic loss of 1p Oncogene 21 3961 3968 10.1038/sj.onc.1205495 12037678 (Pubitemid 34679237)
14. C Li W Wong 2001 Model based analysis of oligonucleotide arrays: expression index computation and outlier detection Proc Natl Acad Sci 98 31 36 10.1073/pnas.011404098 11134512 (Pubitemid 32095858)
15. S Dudoit J Fridlyand T Speed 2002 Comparision of discrimination methods for the classification of tumours using gene expression data J Am Stat Assoc 97 457 10.1198/016214502753479248
16. F Al-Shahrour P Minguez J Tárraga D Montaner E Alloza J Vaquerizas L Conde C Blaschke J Vera J Dopazo 2006 BABELOMICS: a systems biology perspective in the functional annotation of genome-scale experiments Nucleic Acids Res (Web Server issue) 34 W472 W476 10.1093/nar/gkl172 (Pubitemid 44529816)
17. J Nigro M Takahashi D Ginzinger M Law S Passe R Jenkins K Aldape 2001 Detection of 1p and 19q loss in oligodendroglioma by quantitative microsatellite analysis, a real-time quantitative polymerase chain reaction assay Am J Pathol 158 1253 1262 11290543
18. P Berggren R Kumar S Sakano L Hemminki T Wada G Steineck J Adolfsson P Larsson U Norming H Wijkström K Hemminki 2003 Detecting homozygous deletions in the CDKN2A(p16(INK4a))/ARF(p14(ARF)) gene in urinary bladder cancer using real-time quantitative PCR Clin Cancer Res 9 235 242 12538475
19. R Soong B Iacopetta 1997 A rapid and nonisotopic method for the screening and sequencing of p53 gene mutations in formalin-fixed, paraffin-embedded tumors Mod Pathol 10 252 258 9071734
20. Y Ino R Betensky M Zlatescu H Sasaki D Macdonald A Stemmer-Rachamimov D Ramsay J Cairncross D Louis 2001 Molecular subtypes of anaplastic oligodendroglioma: implications for patient management at diagnosis Clin Cancer Res 7 839 845 11309331
21. A Idbaih Y Marie G Pierron C Brennetot K Hoang-Xuan M Kujas K Mokhtari M Sanson J Lejeune A Aurias O Delattre J Delattre 2005 Two types of chromosme 1p losses with opposite significance in gliomas Ann Neurol 58 483 487 10.1002/ana.20607 16130103 (Pubitemid 41266639)
22. M Zlatescu A Yazdi H Sasaki J Megyesi R Betensky D Louis J Cairncross 2001 Tumor location and growth pattern correlate with genetic signature in oligodendroglial neoplasms Cancer Res 61 6713 6715 11559541
23. Q Lu T Sun Z Zhu N Ma M García C Stiles D Rowitch 2002 Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection Cell 109 75 86 10.1016/S0092-8674(02)00678-5 11955448 (Pubitemid 34327518)
24. C Farina F Aloisi E Meini 2007 Astrocytes are active players in cerebral innate immunity Trends Immunol 28 138 145 10.1016/j.it.2007.01.005 17276138 (Pubitemid 46283692)
25. D Widera A Kaus C Kaltschmidt B Kaltschmidt 2007 Neural stem cells, inflammation and NF-kappaB: basic principle of maintenance and repair or origin of brain tumours? J Cell Mol Med 12 459 470 10.1111/j.1582-4934.2007.00208.x 18182066
26. V Clement P Sánchez N de Tribolet I Radovanovic A Ruiz i Altaba 2007 HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity Curr Biol 17 165 172 10.1016/j.cub.2006.11.033 17196391 (Pubitemid 46107823)
27. O Dressen A Brivanlou 2007 Signaling pathways in cancer and embryonic stem cells Stem Cell Rev 3 7 17 10.1007/s12015-007-0004-8 (Pubitemid 47472808)
28. M Benetkiewicz A Idbaih P Cousin B Boisselier Y Marie E Criniere K Hoang-Xuan J Delattre M Sanson O Delattre 2009 NOTCH2 is neither rearranged nor mutated in t(1;19) positive oligodendrogliomas PLoS ONE 4 e4107 10.1371/journal.pone.0004107 19119320
29. F Radtke R Kenneth 2003 The role of notch in tumorigenesis: oncogene or tumour suppressor Nat Rev Cancer 3 756 767 10.1038/nrc1186 14570040
30. S Morrison S Perez Z Qiao J Verdi C Hicks G Weinmaster D Anderson 2000 Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells Cell 101 499 510 10.1016/S0092-8674(00) 80860-0 10850492
31. A Kanner S Staugaitis E Castilla O Chernova R Prayson M Vogelbaum G Stevens D Peereboom J Suh S Lee R Tubbs G Barnett 2006 The impact of genotype on outcome in oligodendroglioma: validation of the loss of chromosome arm 1p as an important factor in clinical decision making J Neurosurg 104 542 550 10.3171/jns.2006.104.4.542 16619658
32. L Mariani G Deiana E Vassella A Fathi M Arnold Murtin I Vijtai J Weis P Siegenthaler M Schobesberger M Reinert 2006 Loss of heterozygosity 1p36 and 19q13 is a prognostic factor for overall survival in patients with diffuse WHO grade 2 gliomas treated without chemotherapy J Clin Oncol 24 4758 4763 10.1200/JCO.2006.05.9238 16966689 (Pubitemid 46630940)