Increase of NADPH-diaphorase expression in hypothalamus of Stat4 knockout mice

Korean Journal of Physiology and Pharmacology

Volumn 13, Issue 5, 2009, Pages 337-341

  Hong, Mee Sook ^a   Song, Jeong Yoon ^b   Yun, Dong Hwan ^a   Cho, Jeong Je ^c   Chung, Joo Ho ^a  

^a Kyung Hee University   (South Korea)

^b Kyung Hee University College of Medicine   (South Korea)

^c Kyung Hee University Hospital   (South Korea)

Author keywords

Body weight; Food intake; Hypothalamus; Knockout mice; Nitric oxide synthase; Stat4

Indexed keywords

NEURONAL NITRIC OXIDE SYNTHASE; PROTEIN FOS; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; STAT4 PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; FOOD INTAKE; HYPOTHALAMUS; HYPOTHALAMUS NUCLEUS; KNOCKOUT MOUSE; MALE; MOUSE; NERVE CELL; NONHUMAN; PROTEIN EXPRESSION; REGULATORY MECHANISM; THALAMUS MIDLINE NUCLEUS; UPREGULATION;

EID: 70450218395     PISSN: 12264512     EISSN: None     Source Type: Journal    
DOI: 10.4196/kjpp.2009.13.5.337     Document Type: Article

References (25)

1. Bredt DS. Endogenous nitric oxide synthesis: biological functions and pathophysiology. Free Radic Res 31: 577-596, 1999.
2. Copeland NG, Gilbert DJ, Schindler C, Zhong Z, Wen Z, Darnell JE Jr, Mui AL, Miyajima A, Quelle FW, Ihle JN, Jenkins NA Distribution of the mammalian Stat gene family in mouse chromosomes. Genomics 29: 225-228, 1995.
3. Darnell JE Jr. STATs and gene regulation. Science 277: 1630-1635, 1997.
4. Darnell JE Jr, Kerr IM, Stark GM. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264: 1415-1421, 1994.
5. Dawson TM, Dawson VL, Snyder SH. A novel neuronal messenger molecule in brain: the free radical, nitric oxide. Ann Neurol 32: 297-311, 1992.
6. Fenton JI, Nuñez NP, Yakar S, Perkins SN, Hard NG, Hursting SD. Diet-induced adiposity alters the serum profile of inflammation in C57BL/6N mice as measured by antibody array. Diabetes Obes Metab 11: 343-354, 2009.
7. Frucht DM, Aringer M, Galon J, Danning C, Brown M, Fan S, Centola M, Wu CY, Yamada N, El Gabalawy H, O'Shea JJ. Stat4 is expressed in activated peripheral blood monocytes, dendritic cells, and macrophages at sites of Th1-mediated inflammation. J Immunol 164: 4659-4664, 2000. (Pubitemid 30238065)
8. Hoey T, Zhang S, Schmidt N, Yu Q, Ramchandani S, Xu X, Naeger LK, Sun YL, Kaplan MH. Distinct requirements for the naturally occurring splice forms Stat4alpha and Stat4beta in IL-12 responses. EMBO J 22: 4237-4248, 2003. (Pubitemid 37021751)
9. Kaplan MH, Sun YL, Hoey T, Grusby MJ. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382: 174-177, 1996. (Pubitemid 26242885)
10. Kataoka TR, Komazawa N, Morii E, Oboki K, Nakano T. Involvement of connective tissue-type mast cells in Th1 immune responses via Stat4 expression. Blood 105: 1016-1020, 2005.
11. Kim MJ, Kim Y, Choe BK, Kim SA, Lee HJ, Kim JW, Huh Y, Kim C, Chung JH. Differential expression of nicotinamide adenine dinucleotide phosphate-diaphorase in hypothalamic areas of obese Zucker rats. Neurosci Lett 292: 60-62, 2000.
12. Min SS. Effects of nos inhibitors on arthritis and arthritic pain in rats. Korean J Physiol Pharmacol 11: 253-257, 2007.
13. Moncada S. The 1991 Ulf von Euler Lecture. The L-arginine: nitric oxide pathway. Acta Physiol Scand 145: 201-227, 1992.
14. Moncada S, Palmer RM, Higgs EA Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43: 109-142, 1991.
15. Morley JE, Flood JF. Competitive antagonism of nitric oxide synthase causes weight loss in mice. Life Sci 51: 1285-1289, 1992.
16. Morley JE, Flood JF. Effect of competitive antagonism of NO synthase on weight and food intake in obese and diabetic mice. Am J Physiol 266: R164-168, 1994.
17. Morley JE, Flood JF. Evidence that nitric oxide modulates food intake in mice. Life Sci 49: 707-711, 1991.
18. Morley JE, Mattammal MB. Nitric oxide synthase levels in obese Zucker rats. Neurosci Lett 209: 137-139, 1996. (Pubitemid 26157806)
19. Raman K, Kaplan MH, Hogaboam CM, Berlin A, Lukacs NW. STAT4 signal pathways regulate inflammation and airway physiology changes in allergic airway inflammation locally via alteration of chemokines. J Immunol 170: 3859-3865, 2003. (Pubitemid 36359257)
20. Reiss CS, Komatsu T, Barna M, Bi Z. Interleukin-12 promotes enhanced recovery from viral infection of neurons in the central nervous system. Ann NY Acad Sci 795: 257-265, 1996. (Pubitemid 27029574)
21. Scherer-Singler U, Vincent SR, Kimura H, McGeer EG. Demonstration of a unique population of neurons with NADPH-diaphorase histochemistry. J Neurosci Methods 9: 229-234, 1983. (Pubitemid 14217618)
22. Squadrito F, Calapai G, Altavilla D, Cucinotta D, Zingarelli B, Campo GM, Arcoraci V, Sautebin L, Mazzaglia G, Caputi AP. Food deprivation increases brain nitric oxide synthase and depresses brain serotonin levels in rats. Neuropharmacology 33: 83-86, 1994. (Pubitemid 24086912)
23. Squadrito F, Calapai G, Cucinotta D, Altavilla D, Zingarelli B, Ioculano M, Urna G, Sardella A, Campo GM, Caputi AP. Anorectic activity of NG-nitro-L-arginine, an inhibitor of brain nitric oxide synthase, in obese Zucker rats. Eur J Pharmacol 230: 125-128, 1993. (Pubitemid 23024993)
24. Thierfelder WE, van Deursen JM, Yamamoto K, Tripp RA, Sarawar SR, Carson RT, Sangster MY, Vignali DA, Doherty PC, Grosveld GC, Ihle JN. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 382: 171-174, 1996. (Pubitemid 26242884)
25. Yang EK. Role of angiotensin II and nitric oxide in the rat paraventricular nucleus. Korean J Physiol Pharmacol 5: 41-46, 2001. (Pubitemid 32229810)