Functional recovery after the repair of transected cervical roots in the chronic stage of injury

Journal of Neurotrauma

Volumn 26, Issue 10, 2009, Pages 1795-1804

  Huang, Ming Chao ^a,b,c   Lo, Ming Jei ^a   Lin, Yi Lo ^a   Chang, Shao En ^a   Huang, Wen Chung ^a,b   Kuo, Wen Chun ^a   Tsai, May Jywan ^a   Kuo, Huai Sheng ^a   Shih, Yang Hsin ^a,b,c   Cheng, Henrich ^a,b  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

AFGF; Cervical roots; Functional recovery; Nerve graft

Indexed keywords

ACIDIC FIBROBLAST GROWTH FACTOR; FIBRIN GLUE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATROPHY; CELL SURVIVAL; CERVICAL SPINAL CORD; CHRONIC DISEASE; CONTROLLED STUDY; CONVALESCENCE; DRUG EFFECT; FEMALE; MOTONEURON; NERVE FIBER REGENERATION; NERVE ROOT INJURY; NERVE TRANSECTION; NERVE TRANSPLANTATION; NONHUMAN; OUTCOME ASSESSMENT; RAT; SENSORIMOTOR FUNCTION; SPINAL CORD DORSAL HORN; TREATMENT OUTCOME;

ANIMALS; CELL SURVIVAL; CERVICAL VERTEBRAE; CHOLERA TOXIN; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; FEMALE; FIBRIN TISSUE ADHESIVE; FIBROBLAST GROWTH FACTORS; HORSERADISH PEROXIDASE; INTERCOSTAL NERVES; MOTOR NEURONS; NERVE DEGENERATION; NERVE REGENERATION; NEURONAL TRACT-TRACERS; NEUROSURGICAL PROCEDURES; POSTERIOR HORN CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; RHIZOTOMY; SPINAL CORD; SPINAL NERVE ROOTS; TISSUE TRANSPLANTATION; TREATMENT OUTCOME;

EID: 70450191623     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.2008.0529     Document Type: Article

References (46)

1. Abercrombie, M. (1946). Estimation of nuclear population from microtome sections. Anat. Rec. 94, 239-1147
2. Bertelli, J.A., Taleb,M., Saadi, A.,Mira, J.C., and Pecot-Dechavassine, M. (1995). The rat brachial plexus and its terminal branches: An experimentalmodel for the study of peripheral nerve regeneration. Microsurgery 16, 77-85.
3. Birch, R. (1998). Traumatic lesions of the brachial plexus, in: Surgical disorders of the peripheral nerves. R. Birch, G. Bonney, and C. B. Wynn Parry (eds). Churchill Livingstone: Edinburgh London, pps. 157-207.
4. Boyd, J.G., and Gordon, T. (2003a). Glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor sustain the axonal regeneration of chronically axotomized motoneurons in vivo. Exp. Neurol. 183, 610-619.
5. Boyd, J.G., and Gordon, T. (2003b). Neurotrophic factors and their receptors in axonal regeneration and functional recovery after peripheral nerve injury. Mol. Neurobiol. 27, 277-324.
6. Carlstedt, T., Grane, P., Hallin, R.G., and Noren, G. (1995). Return of function after spinal cord implantation of avulsed spinal nerve roots. Lancet 346, 1323-1325.
7. Carlstedt, T., Linda, H., Cullheim, S., and Risling, M. (1986). Reinnervation of hind limb muscles after ventral root avulsion and implantation in the lumbar spinal cord of the adult rat. Acta Physiol. Scand. 128, 645-646.
8. Carlstedt, T.P., Hallin, R.G., Hedstrom, K.G., and Nilsson- Remahl, I.A. (1993). Functional recovery in primates with brachial plexus injury after spinal cord implantation of avulsed ventral roots. J. Neurol. Neurosurg. Psychiatry 56, 649-654.
9. Chai, H., Wu, W., So, K.F., and Yip, H.K. (2000). Survival and regeneration of motoneurons in adult rats by reimplantation of ventral root following spinal root avulsion. Neuroreport 11, 1249-1252.
10. Chuang, T.Y., Huang, M.C., Chen, K.C., Chang, Y.C., Yen, Y.S., Lee, L.S., and Cheng, H. (2002). Forelimb muscle activity following nerve graft repair of ventral roots in the rat cervical spinal cord. Life Sci. 71, 487-496.
11. Corfas, G., Velardez, M.O., Ko, C.P., Ratner, N., and Peles, E. (2004). Mechanisms and roles of axon-Schwann cell interactions. J. Neurosci. 24, 9250-9260.
12. Cullheim, S., Carlstedt, T., Linda, H., Risling, M., and Ulfhake, B. (1989). Motoneurons reinnervate skeletal muscle after ventral root implantation into the spinal cord of the cat. Neuroscience 29, 725-733.
13. Fu, S.Y., and Gordon, T. (1995a). Contributing factors to poor functional recovery after delayed nerve repair: Prolonged axotomy. J. Neurosci. 15, 3876-3885.
14. Fu, S.Y., and Gordon, T. (1995b). Contributing factors to poor functional recovery after delayed nerve repair: Prolonged denervation. J. Neurosci. 15, 3886-3895.
15. Giacobini, M.M., Hoffer, B.J., Zerbe, G., and Olson, L. (1991). Acidic and basic fibroblast growth factors augment growth of fetal brain tissue grafts. Exp. Brain Res. 86, 73-81.
16. Giannini, C., and Dyck, P.J. (1990). The fate of Schwann cell basement membranes in permanently transected nerves. J. Neuropathol. Exp. Neurol. 49, 550-563.
17. Glasby, M.A., and Hems, T.E. (1995). Repairing spinal roots after brachial plexus injuries. Paraplegia 33, 359-361.
18. Gordon, T., Sulaiman, O., and Boyd, J.G. (2003). Experimental strategies to promote functional recovery after peripheral nerve injuries. J. Peripher. Nerv. Syst. 8, 236-250.
19. Gu, H.Y., Chai, H., Zhang, J.Y., Yao, Z.B., Zhou, L.H., Wong, W.M., Bruce, I.C., and Wu, W.T. (2005). Survival, regeneration and functional recovery of motoneurons after delayed reimplantation of avulsed spinal root in adult rat. Exp. Neurol. 192, 89-99.
20. Guest, J. (1996). The potential for human Schwann cell grafts to influence spinal cord regeneration in the nude rat. Ph.D. Thesis, University of Miami.
21. Hoke, A., Sun, H.S., Gordon, T., and Zochodne, D.W. (2001). Do denervated peripheral nerve trunks become ischemic? The impact of chronic denervation on vasa nervorum. Exp. Neurol. 172, 398-406.
22. Houghton, A.K., Valdez, J.G., and Westlund, K.N. (1998). Peripheral morphine administration blocks the development of hyperalgesia and allodynia after bone damage in the rat. Anesthesiology 89, 190-201.
23. Hsu, S.P., Shih, Y.H., Huang, M.C., Chuang, T.Y., Huang, W.C., Wu, H.M., Lin, P.H., Lee, L.S., and Cheng, H. (2004). Repair of multiple cervical root avulsion with sural nerve graft. Injury 35, 896-907.
24. Huang, M.C., Chang, P.T., Tsai, M.J., Kuo, H.S., Kuo, W.C., Lee, M.J., Lo, M.J., Lee, I.H., Huang, W.C., Lee, L.M., Shih, Y.H., Lee, L.S., and Cheng, H. (2007). Sensory and motor recovery after repairing transected cervical roots. Surg. Neurol. 68, S1, 17-24.
25. Huang, M.C., Chen, K.C., Chuang, T.Y., Chang, W.C., Lee, L.S., Huang, W.C., and Cheng, H. (2003). Cervical root repair in adult rats after transection: recovery of forelimb motor function. Exp. Neurol. 180, 101-109.
26. Jivan, S., Novikova, L.N., Wiberg, M., and Novikov, L.N. (2006). The effects of delayed nerve repair on neuronal survival and axonal regeneration after seventh cervical spinal nerve axotomy in adult rats. Exp. Brain Res. 170, 245-254.
27. Klagsbrun, M. (1989). The fibroblast growth factor family: Structural and biological properties. Prog. Growth Factor Res. 1, 207-235.
28. Lee, L.M., Huang, M.C., Chuang, T.Y., Lee, L.S., Cheng, H., and Lee, I.H. (2004). Acidic FGF enhances functional regeneration of adult dorsal roots. Life Sci. 74, 1937-1943.
29. Li, H., Terenghi, G., and Hall, S.M. (1997). Effects of delayed reinnervation on the expression of c-erbB receptors by chronically denervated rat Schwann cells in vivo. Glia 20, 333-347.
30. Liuzzi, F.J., and Lasek, R.J. (1987). Astrocytes block axonal regeneration in mammals by activating the physiological stop pathway. Science 237, 642-645.
31. Low, H.L., Nogradi, A., Vrbova, G., and Greensmith, L. (2003). Axotomized motoneurons can be rescued from cell death by peripheral nerve grafts: The effect of donor age. J. Neuropathol. Exp. Neurol. 62, 75-87.
32. Lundborg, G., Dahlin, L., Danielsen, N., and Zhao, Q. (1994). Trophism, tropism, and specificity in nerve regeneration. J. Reconstr. Microsurg. 10, 345-354.
33. Ma, J., Novikov, L.N., Kellerth, J.O., and Wiberg, M. (2003). Early nerve repair after injury to the postganglionic plexus: An experimental study of sensory and motor neuronal survival in adult rats. Scand. J. Plast. Reconstr. Surg. Hand Surg. 37, 1-9.
34. Ma, J., Novikov, L.N., Wiberg, M., and Kellerth, J.O. (2001). Delayed loss of spinal motoneurons after peripheral nerve injury in adult rats: A quantitative morphological study. Exp. Brain Res. 139, 216-223.
35. Millesi, H. (1988). Brachial plexus injuries. Nerve grafting. Clin. Orthop. Relat. Res. 36-42.
36. Narakas, A.O. (1993). Lesions found when operating traction injuries of the brachial plexus. Clin. Neurol. Neurosurg. 95 Suppl, S56-64.
37. Nishi, R. (1994). Neurotrophic factors: Two are better than one. Science 265, 1052-1053.
38. Ornitz, D.M., Xu, J., Colvin, J.S., McEwen, D.G., MacArthur, C.A., Coulier, F., Gao, G., and Goldfarb, M. (1996). Receptor specificity of the fibroblast growth factor family. J. Biol. Chem. 271, 15292-15297.
39. Plantman, S., Novikova, L., Novikov, L., Hammarberg, H., Wallquist, W., Kellerth, J.O., and Cullheim, S. (2005). Integrin messenger RNAs in the red nucleus after axotomy and neurotrophic administration. Neuroreport 16, 709-713.
40. Seki, T., and Fehlings, M.G. (2008). Mechanistic insights into posttraumatic syringomyelia based on a novel in vivo animal model. Laboratory investigation. J. Neurosurg. Spine 8, 365-375.
41. Tandrup, T., Woolf, C.J., and Coggeshall, R.E. (2000). Delayed loss of small dorsal root ganglion cells after transection of the rat sciatic nerve. J. Comp. Neurol. 422, 172-180.
42. Terenghi, G. (1999). Peripheral nerve regeneration and neurotrophic factors. J. Anat. 194 (Pt 1), 1-14.
43. Terzis, J.K., Vekris, M.D., and Soucacos, P.N. (1999). Outcomes of brachial plexus reconstruction in 204 patients with devastating paralysis. Plast. Reconstr. Surg. 104, 1221-1240.
44. Thomeer, R.T., and Malessy, M.J. (1993). Surgical repair of brachial plexus injury. Clin. Neurol. Neurosurg. 95 Suppl, S65-72.
45. Wu, W., Chai, H., Zhang, J., Gu, H., Xie, Y., and Zhou, L. (2004). Delayed implantation of a peripheral nerve graft reduces motoneuron survival but does not affect regeneration following spinal root avulsion in adult rats. J. Neurotrauma 21, 1050-1058.
46. You, S., Petrov, T., Chung, P.H., and Gordon, T. (1997). The expression of the low affinity nerve growth factor receptor in long-term denervated Schwann cells. Glia 20, 87-100.