Etiology, baseline characteristics, and biochemical diagnosis of GH deficiency in the adult: Are there regional variations?

European Journal of Endocrinology

Volumn 161, Issue SUPPL. 1, 2009, Pages

  Brabant, G ^a   Poll, E M ^b   Jonsson P ^c   Polydorou, D ^a   Kreitschmann Andermahr, I ^a,b  

^a CHRISTIE HOSPITAL   (United Kingdom)

^b UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPID; RECOMBINANT GROWTH HORMONE; BIOLOGICAL MARKER; GLUCAGON; HUMAN GROWTH HORMONE; INSULIN; SOMATOMEDIN C;

ADULT; ARTICLE; BIOCHEMISTRY; BODY MASS; CLINICAL FEATURE; CONTROLLED STUDY; CRANIOPHARYNGIOMA; ENDOCRINE FUNCTION TEST; ENDOCRINE SURGERY; EUROPE; FEMALE; GEOGRAPHIC DISTRIBUTION; GROWTH HORMONE DEFICIENCY; HUMAN; HYPOPHYSIS ADENOMA; LABORATORY TEST; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; ONSET AGE; PATHOGENESIS; PHARMACOEPIDEMIOLOGY; PRIORITY JOURNAL; UNITED STATES; BLOOD; BLOOD PRESSURE; COMPARATIVE STUDY; FACTUAL DATABASE; HYPOPITUITARISM; LIPID METABOLISM; METABOLISM; MIDDLE AGED; QUALITY OF LIFE;

ADULT; BIOLOGICAL MARKERS; BLOOD PRESSURE; BODY MASS INDEX; DATABASES, FACTUAL; EUROPE; FEMALE; GLUCAGON; HUMAN GROWTH HORMONE; HUMANS; HYPOPITUITARISM; INSULIN; INSULIN-LIKE GROWTH FACTOR I; LIPID METABOLISM; MALE; MIDDLE AGED; QUALITY OF LIFE; UNITED STATES;

EID: 70450174436     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-09-0273     Document Type: Article

References (33)

1. de Boer H, Blok GJ & Van der Veen EA. Clinical aspects of growth hormone deficiency in adults. Endocrine Reviews 1995 16 63-86.
2. Carroll PV, Christ ER, Bengtsson BA, Carlsson L, Christiansen JS, Clemmons D, Hintz R, Ho K, Laron Z, Sizonenko P, Sönksen PH, Tanaka T & Thorne M. Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. Growth Hormone Research Society Scientific Committee. Journal of Clinical Endocrinology and Metabolism 1998 83 382-395.
3. Shalet SM, Toogood A, Rahim A & Brennan BM. The diagnosis of growth hormone deficiency in children and adults. Endocrine Reviews 1998 19 203-223. (Pubitemid 29114291)
4. Woodhouse LJ, Mukherjee A, Shalet SM & Ezzat S. The influence of growth hormone status on physical impairments, functional limitations, and health-related quality of life in adults. Endocrine Reviews 2006 27 287-317.
5. Stochholm K, Laursen T, Green A, Laurberg P, Andersen M, Kristensen LØ, Feldt-Rasmussen U, Christiansen JS, Frydenberg M & Gravholt CH. Morbidity and GH deficiency: a nationwide study. European Journal of Endocrinology 2008 158 447-457.
6. Stochholm K, Gravholt CH, Laursen T, Laurberg P, Andersen M, Kristensen LØ, Feldt-Rasmussen U, Christiansen JS, Frydenberg M & Green A. Mortality and GH deficiency: a nationwide study. European Journal of Endocrinology 2007 157 9-18.
7. Abs R, Mattsson AF, Bengtsson BA, Feldt-Rasmussen U, Goth MI, Koltowska-Häggström M, Monson JP, Verhelst J & Wilton P. Isolated growth hormone (GH) deficiency in adult patients: baseline clinical characteristics and responses to GH replacement in comparison with hypopituitary patients. A sub-analysis of the KIMS database. Growth Hormone and IGF Research 2005 15 349-359. (Pubitemid 41408413)
8. Webb SM, Strasburger CJ, Mo D, Hartman ML, Melmed S, Jung H, Blum WF & Attanasio AF. Changing patterns of the adult growth hormone deficiency diagnosis documented in a decade-long global surveillance database. Journal of Clinical Endocrinology and Metabolism 2009 94 392-399.
9. Rosen T, Eden S, Larson G, Wilhelmsen L & Bengtsson BA. Cardiovascular risk factors in adult patients with growth hormone deficiency. Acta Endocrinologica 1993 129 195-200. (Pubitemid 23295679)
10. Bülow B, Hagmar L, Mikoczy Z, Nordström CH & Erfurth EM. Increased cerebrovascular mortality in patients with hypopituitarism. Clinical Endocrinology 1997 46 75-81. (Pubitemid 27072849)
11. Verhelst J & Abs R. Long-term growth hormone replacement therapy in hypopituitary adults. Drugs 2002 62 2399-2412. (Pubitemid 35316388)
12. Monson JP & Jönsson P. Aspects of growth hormone (GH) replacement in elderly patients with GH deficiency: data from KIMS. Hormone Research 2003 60 112-120. (Pubitemid 37107337)
13. Höybye C, Jönsson P, Monson JP, Koltowska-Häggström M, Hana V, Geffner M & Abs R. Impact of the primary aetiology upon the clinical outcome of adults with childhood-onset GH deficiency. European Journal of Endocrinology 2007 157 589-596. (Pubitemid 350187375)
14. Verhelst J, Kendall-Taylor P, Erfurth EM, Price DA, Geffner M, Koltowska-Häggström M, Jönsson PJ, Wilton P & Abs R. Baseline characteristics and response to 2 years of growth hormone (GH) replacement of hypopituitary patients with GH deficiency due to adult-onset craniopharyngioma in comparison with patients with nonfunctioning pituitary adenoma: data from KIMS (Pfizer International Metabolic Database). Journal of Clinical Endocrinology and Metabolism 2005 90 4636-4643. (Pubitemid 41166526)
15. Kendall-Taylor P, Jönsson PJ, Abs R, Erfurth EM, Koltowska- Häggström M, Price DA & Verhelst J. The clinical, metabolic and endocrine features and the quality of life in adults with childhood-onset craniopharyngioma compared with adult-onset craniopharyngioma. European Journal of Endocrinology 2005 152 557-567. (Pubitemid 40575801)
16. Maiter D, Abs R, Johannsson G, Scanlon M, Jönsson PJ, Wilton P & Koltowska-Häggström M. Baseline characteristics and response to GH replacement of hypopituitary patients previously irradiated for pituitary adenoma or craniopharyngioma: data from the Pfizer International Metabolic Database. European Journal of Endocrinology 2006 155 253-260. (Pubitemid 44269441)
17. Achterberg PW, Kramers PG & van Oers HA. European community health monitoring: the EUPHIX-model. Scandinavian Journal of Public Health 2008 36 676-684.
18. van der Klaauw AA, Biermasz NR, Feskens EJ, Bos MB, Smit JW, Roelfsema F, Corssmit EP, Pijl H, Romijn JA & Pereira AM. The prevalence of the metabolic syndrome is increased in patients with GH deficiency, irrespective of long-term substitution with recombinant human GH. European Journal of Endocrinology 2007 156 455-462. (Pubitemid 46672646)
19. Abs R, Feldt-Rasmussen U, Mattsson AF, Monson JP, Bengtsson BA, Goth MI, Wilton P & Koltowska-Häggström M. Determinants of cardiovascular risk in 2589 hypopituitary GH-deficient adults - a KIMS database analysis. European Journal of Endocrinology 2006 155 79-90. (Pubitemid 44109069)
20. Maison P, Balkau B, Souberbielle JC, Cunin P, Vol S, Macquin- Mavier I & Eschwege E. Evidence for distinct effects of GH and IGF-I in the metabolic syndrome. Diabetic Medicine 2007 24 1012-1018.
21. Colao A, Di Somma C, Spiezia S, Savastano S, Rota F, Savanelli MC & Lombardi G. Growth hormone treatment on atherosclerosis: results of a 5-year open, prospective, controlled study in male patients with severe growth hormone deficiency. Journal of Clinical Endocrinology and Metabolism 2008 93 3416-3424.
22. Moock J, Albrecht C, Friedrich N, Völzke H, Nauck M, Koltowska- Häggström M, Kohlmann T & Wallaschofski H. Health-related quality of life and IGF-1 in GH-deficient adult patients on GH replacement therapy: analysis of the German KIMS data and the Study of Health in Pomerania. European Journal of Endocrinology 2009 160 17-24.
23. Saller B, Mattsson AF, Kann PH, Koppeschaar HP, Svensson J, Pompen M & Koltowska-Häggström M. Healthcare utilization, quality of life and patient-reported outcomes during two years of GH replacement therapy in GH-deficient adults - comparison between Sweden, The Netherlands and Germany. European Journal of Endocrinology 2006 154 843-850. (Pubitemid 43997723)
24. Aimaretti G, Corneli G, Baldelli R, Di Somma C, Gasco V, Durante C, Ausiello L, Rovere S, Grottoli S, Tamburrano G & Ghigo E. Diagnostic reliability of a single IGF-I measurement in 237 adults with total anterior hypopituitarism and severe GH deficiency. Clinical Endocrinology 2003 59 56-61. (Pubitemid 36774108)
25. Hartman ML, Crowe BJ, Biller BM, Ho KK, Clemmons DR & Chipman JJ. Which patients do not require a GH stimulation test for the diagnosis of adult GH deficiency? Journal of Clinical Endocrinology and Metabolism 2002 87 477-485.
26. Casanueva FF, Pombo M, Leal A, Popovic V & Dieguez C. Biochemical diagnosis of growth hormone deficiency in adults. In Growth Hormone Deficiency in Adults - 10 Years of KIMS, ch 9, pp 91-101. Eds R Abs & U Feldt-Rasmussen. Oxford: Oxford PharmaGenesis Ltd, 2004.
27. Molitch ME, Clemmons DR, Malozowski S, Merriam GR, Shalet SM, Vance ML & Stephens PA. Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society Clinical Practice Guideline. Journal of Clinical Endocrinology and Metabolism 2006 91 1621-1634.
28. Pfeifer M, Kanc K, Verhovec R & Kocijancic A. Reproducibility of the insulin tolerance test (ITT) for assessment of growth hormone and cortisol secretion in normal and hypopituitary adult men. Clinical Endocrinology 2001 54 17-22. (Pubitemid 32158700)
29. Hoeck HC, Vestergaard P, Jakobsen PE & Laurberg P. Test of growth hormone secretion in adults: poor reproducibility of the insulin tolerance test. European Journal of Endocrinology 1995 133 305-312.
30. Brabant G, Krogh Rasmussen A, Biller BM, Buchfelder M, Feldt- Rasmussen U, Forssmann K, Jonsson B, Koltowska-Häggström M, Maiter D, Saller B & Toogood A. Clinical implications of residual growth hormone (GH) response to provocative testing in adults with severe GH deficiency. Journal of Clinical Endocrinology and Metabolism 2007 92 2604-2609. (Pubitemid 47037364)
31. Popovic V, Pekic S, Doknic M, Micic D, Damjanovic S, Zarkovic M, Aimaretti G, Corneli G, Ghigo E, Deiguez C & Casanueva FF. The effectiveness of arginine C GHRH test compared with GHRH C GHRP-6 test in diagnosing growth hormone deficiency in adults. Clinical Endocrinology 2003 59 251-257. (Pubitemid 36918662)
32. Corneli G, Di SC, Baldelli R, Rovere S, Gasco V, Croce CG, Grottoli S, Maccario M, Colao A, Lombardi G, Ghigo E, Camanni F & Aimaretti G. The cut-off limits of the GH response to GH-releasing hormone-arginine test related to body mass index. European Journal of Endocrinology 2005 153 257-264. (Pubitemid 41174451)
33. Biller BM, Samuels MH, Zagar A, Cook DM, Arafah BM, Bonert V, Stavrou S, Kleinberg DL, Chipman JJ & Hartman ML. Sensitivity and specificity of six tests for the diagnosis of adult GH deficiency. Journal of Clinical Endocrinology and Metabolism 2002 87 2067-2079. (Pubitemid 34521490)