Changing patterns of the adult growth hormone deficiency diagnosis documented in a decade-long global surveillance database

Journal of Clinical Endocrinology and Metabolism

Volumn 94, Issue 2, 2009, Pages 392-399

  Webb, Susan M ^a   Strasburger, Christian J ^b   Mo, Daojun ^c   Hartman, Mark L ^c   Melmed, Shlomo ^d   Jung, Heike ^e   Blum, Werner F ^e   Attanasio, Andrea F ^f  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c ELI LILLY AND COMPANY   (United States)

^d CEDARS SINAI MEDICAL CENTER   (United States)

^e LILLY DEUTSCHLAND GMBH   (Germany)

^f Cascina del Rosone   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CLONIDINE; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; LEVODOPA; SOMATOMEDIN BINDING PROTEIN 1;

ADULT; ARTICLE; CLINICAL PRACTICE; CONTROLLED STUDY; CRANIOPHARYNGIOMA; DEMOGRAPHY; DIAGNOSTIC TEST; FEMALE; GROWTH HORMONE DEFICIENCY; HUMAN; HYPOPHYSIS ADENOMA; HYPOPHYSIS DISEASE; IDIOPATHIC DISEASE; MAJOR CLINICAL STUDY; MALE; PITUITARY HEMORRHAGE; PRIORITY JOURNAL;

EID: 59849107735     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2008-0713     Document Type: Article

References (41)

1. Carroll PV, Christ ER, Bengtsson BA, Carlsson L, Christiansen JS, Clemmons D, Hintz R, Ho K, Laron Z, Sizonenko P, Sonksen PH, Tanaka T, Thorner M 1998 Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. Growth Hormone Research Society Scientific Committee. J Clin Endocrinol Metab 83:382-395
2. Attanasio AF, Bates PC, Ho KK, Webb SM, Ross RJ, Strasburger CJ, Bouillon R, Crowe B, Selander K, Valle D, Lamberts SW 2002 Hypopituitary Control and Complications Study International Advisory Board. Human growth hormone replacement in adult hypopituitary patients: long-term effects on body composition and lipid status - 3-year results from the HypoCCS database. J Clin Endocrinol Metab 87:1600-1606
3. Johansson G 2007 Management of adult growth hormone deficiency. Endocr Metab Clin North Am 36:203-220
4. van der Klaauw AA, Romijn JA, Biermasz NR, Smit JW, van Doorn J, Dekkers OM, Roelfsema F, Pereira AM 2006 Sustained effects of recombinant GH replacement after 7 years of treatment in adults with GH deficiency. Eur J Endocrinol 155:701-708
5. Gibney J, Wallace JD, Spinks T, Schnorr L, Ranicar A, Cuneo RC, Lockhart S, Burnand KG, Salomon F, Sonksen PH, Russell-Jones D 1999 The effects of 10 years of recombinant human growth hormone in adult GH deficient patients. J Clin Endocrinol Metab 84:2596-2602
6. Götherström G, Bengtsson BA, Bosaeus BA, Johannsson G, Svensson J 2007 A 10-year, prospective study of the metabolic effects of growth hormone replacement in adults. J Clin Endocrinol Metab 92:1442-1445
7. Salomon F, Cuneo RD, Hesp R, Sönksen PH 1989 The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N Engl J Med 321:1797-1803
8. Binnerts A, Swart GR, Wilson JH, Hoogerbrugge N, Pols HA, Birkenhager JC 1992 The effect of growth hormone administration in growth hormone deficient adults on bone, protein, carbohydrate and lipid homeostasis, as well as on body composition. Clin Endocrinol (Oxf) 37:79-87
9. Bengtsson BA, Eden S, Lonn L, Kvis H, Stokland A, Lindstedt G, Bosaeus I, Tolli J, Sjostrom E, Isaksson OG 1993 Treatment of adults with growth hormone deficiency with recombinant human GH. J Clin Endocrinol Metab 76:309-317
10. Attanasio AF, Lamberts SWJ, Matranga AMC, Birkett MA, Bates PC, Valk NK, Hilsted J, Bengtsson BA, Strasburger CJ 1997 Adult growth hormone (GH)-deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment. J Clin Endocrinol Metab 82:82-88
11. Hoffman AR, Kuntze JE, Baptista J, Baum HBA, Baumann GP, Biller BMK, Clark RV, Cook D, Inzucchi SE, Kleinberg D, Klibanski A, Phillips LS, Ridgway EC, Robbins RJ, Schlechte J, Sharma M, Thorner MO, Vance ML 2004 Growth hormone (GH) replacement therapy in adult-onset GH deficiency: effects on body composition in men and women in a double-blind, randomized, placebo-controlled trial. J Clin Endocrinol Metab 89:2048-2056
12. Chihara K, Koledova E, Shimatsu A, Kato Y, Kohno H, Tanaka T, Teramoto A, Bates PC, Attanasio AF 2004 Adult GH deficiency in Japanese patients: effects of GH treatment in a randomised, placebo-controlled trial. Eur J Endocrinol 151:343-350
13. Chihara K, Koledova E, Shimatsu A, Kato Y, Kohno H, Tanaka T, Teramoto A, Bates PC, Attanasio AF 2005 An individualized GH dose regimen for longterm GH treatment in Japanese patients with adult GH deficiency. Eur J Endocrinol 153:57-65
14. Ghigo E, Aimaretti G, Corneli G 2008 Diagnosis of adult GH deficiency. Growth Horm IGF Res 18:1-16
15. Toogood A 2007 Growth hormone tests: are they all the same? Horm Res 68(Suppl 5):66-67
16. 2008 Humatrope. Summary of product characteristics United Kingdom. http:// emc.medicines.org.uk/emc/assets/c/html/displaydoc.asp?DocumentID=601 [accessed 20 March 2008]
17. 2006 Humatrope [package insert]. Indianapolis: Eli Lilly, Co.
18. 2004 Agenzia Italiana del Farmaco (AIFA). Health Ministries guidelines for treatment of adults with GHD, Ministry of Health, Italy. Nota 39:53
19. 2008 Criterios para la utilizacion racional de la hormona de crecimiento en adultos. Health Ministries guidelines for treatment of adults with GHD, Ministry of Health, Spain. www.msc.es/profesionales/farmacia/pdf/ CriteriosHCAdultos.pdf [accessed 20 March 2008]
20. National Institute for Clinical Excellence (NICE) 2003 Growth hormone deficiency (adults) - human growth hormone. Guidelines of the British National Institute for Clinical Excellence. Technology appraisal August 2003. http:// guidance.nice.org.uk/TA64 [accessed 20 March 2008]
21. Biller BMK, Vance ML, Kleinberg DL, Cook DM, Gordon T 2000 Clinical and reimbursement issues in growth hormone use in adults. Am J Manag Care 6(15 Suppl):S817-S827
22. 1998 Consensus guidelines for the diagnosis and treatment of adult with growth hormone deficiency: summary statement of the Growth Hormone Research Society Workshop on adult growth hormone deficiency. J Clin Endocrinol Metab 83:379-381
23. Molitch ME, Clemmons DR, Malozowski S, Merriam GR, Shalet SM, Vance ML 2006 Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 91: 1621-1634
24. Ho KK 2007 GH Deficiency Consensus Workshop Participants. 2007 Consensus guidelines for the diagnosis and treatment of adults with GH deficiency II: a statement of the GH Research Society in association with the European Society for Pediatric Endocrinology, Lawson Wilkins Society, European Society of Endocrinology, Japan Endocrine Society, and Endocrine Society of Australia. Eur J Endocrinol 157:695-700
25. Gharib H, Cook DM, Saenger PH, Bengtsson BA, Feld S, Nippoldt TB, Rodbard HW, Seibel JA, Vance ML, Zimmerman D, Palumbo PJ, Bergman DA, Garber JR, Hamilton Jr CR, Petal SM, Rettinger HI, Service FJ, Shankar TP, Stoffer SS, Tourletot JB, AACE Growth Hormone Task Force 2003 American Association of Clinical Endocrinologists medical guidelines for clinical practice for growth hormone use in adults and children-2003 update. Endocr Pract 9:64-76
26. Blum WF, Breier BH 1994 Radioimmunoassays for IGFs and IGFBPs. Growth Regul 4(Suppl 1):11-19
27. Hartman ML, Crowe BJ, Biller BMK, Ho KKY, Clemmons DR, Chipman JJ 2002 Which patients do not require a growth hormone (GH) stimulation test for the diagnosis of adult GH deficiency? J Clin Endocrinol Metab 87:477-485
28. Biller BMK, Samuels MH, Zagar A, Cook DM, Arafah BM, Bonert V, Stavrou S, Kleinberg DL, Chipman JJ, Hartman ML 2002 Sensitivity and specificity of six tests for the diagnosis of adult GH deficiency. J Clin Endocrinol Metab 87:2067-2079
29. Blum WF, Schweizer R 2003 Insulin-like growth factors and their binding proteins. In: Ranke M, ed. Diagnostics of endocrine function in children and adolescents. Basel, Switzerland: Karger Publishers; 166-199
30. Corneli G, Di Somma C, Baldelli R, Rovere S, Gasco V, Croce CG, Grottoli S, Maccario M, Colao A, Lombardi G, Ghigo E, Camanni F, Aimaretti G 2005 The cut-off limits of the GH response to GH-releasing hormone-arginine test related to body mass index. Eur J Endocrinol 153:257-264
31. Corneli G, Di Somma C, Prodam F, Bellone J, Bellone S, Gasco V, Baldelli R, Rovere S, Schneider HJ, Gargantini L, Gastaldi R, Ghizzoni L, Valle D, Salerno M, Colao A, Bona G, Ghigo E, Maghnie M, Aimaraetti G 2007 Cut-off limits of the GH response to GHRH plus arginine test and IGF-I levels for the diagnosis of GH deficiency in late adolescents and young adults. Eur J Endocrinol 157:701-708
32. Mattsson AF, Koltowska-Häggström M, Saller B, Gaillard R 2008 Total and cause specific mortality in patients from the KIMS database: direct evidence for a beneficial effect of GH replacement therapy on mortality in adult GH deficient patients. 10th European Congress of Endocrinology, Endocrine Abstracts. www.endocrine-abstracts.org 16:P404
33. Abs R, Feldt-Rasmussen U, Mattson AF, Monson JP, Bengtsson BA, Goth MI, Wilton P, Koltowska-Haggstrom M 2006 Determinants of cardiovascular risk factors in 2589 hypopituitary GH-deficient adults - a KIMS database analysis. Eur J Endocrinol 155:79-80
34. Filipsson H, Monson JP, Koltowska-Haggstrom M, Mattsson A, Johannsson G 2006 The impact of glucocorticoid replacement regimens on metabolic outcome and comorbidity in hypopituitary patients. J Clin Endocrinol Metab 91:3954-3961
35. Murray RD, Adams JE, Shalet SM 2004 Adults with partial growth hormone deficiency have an adverse body composition. J Clin Endocrinol Metab 89: 1586-1591
36. Murray RD, Bidlingmeier M, Strasburger CJ, Shalet SM 2007 The diagnosis of partial GH deficiency in adults with a putative insult to the hypothalamopituitary axis. J Clin Endocrinol Metab 2007 92:1705-1709
37. Colao A, Di Somma C, Spiezia S, Rota F, Pivonello R, Savastano S, Lombardi G 2006 The natural history of partial growth hormone deficiency in adults: a prospective study on the cardiovascular risk and atherosclerosis. J Clin Endocrinol Metab 91:2191-2200
38. Bonert VS, Elashoff JD, Barnettt P, Melmed S 2004 Body mass index determines evoked growth hormone (GH) responsiveness in normal healthy male subjects: diagnostic caveat for adult GH deficiency J Clin Endocrinol Metab 89:3397-3401
39. Williams T, Berelowitz M, Joffe SN, Thorner MO, Rivier J, Vale W, Frohman LA 1984 Impaired growth hormone responses to growth hormone releasing factor in obesity. A pituitary defect reversed with weight reduction. N Engl J Med 311:1403-1407
40. Melmed S 2006 Supplemental growth hormone in healthy adults: the endocrinologist's responsibility. Nat Clin Pract Endocrinol Metab 2:119
41. Zadik Z, Chalew SA, McCarter Jr RJ, Meistas M, Kowarski AA 1985 The influence of age on the 24-hour integrated concentration of growth hormone in normal individuals. J Clin Endocrinol Metab 60:513-516