메뉴 건너뛰기




Volumn 30, Issue 5-6, 2009, Pages 276-285

Co-expression of p53 and bcl-2 proteins in human papillomavirus-induced premalignant lesions of the uterine cervix: Correlation with progression to malignancy

Author keywords

Bcl 2; Cervical cancer; Human papillomavirus; P53; Squamous intraepithelial lesion

Indexed keywords

BIOTIN; PEROXIDASE; PROTEIN BCL 2; PROTEIN P53; REGULATOR PROTEIN; STREPTAVIDIN; VIRUS DNA;

EID: 70450173171     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1159/000259911     Document Type: Article
Times cited : (7)

References (48)
  • 1
    • 0026444642 scopus 로고
    • Detection of human papillomavirus in cervical scrapes by the polymerase chain reaction in relation to cytology: Possible implications for cervical cancer screening
    • Meijer CJ, Van den Brule AJ, Snijders PJ, Helmerhorst T, Kenemans P, Walboomers JM: Detection of human papillomavirus in cervical scrapes by the polymerase chain reaction in relation to cytology: possible implications for cervical cancer screening. IARC Sci Publ 1992; 119: 271-281.
    • (1992) IARC Sci Publ , vol.119 , pp. 271-281
    • Meijer, C.J.1    Van Den Brule, A.J.2    Snijders, P.J.3    Helmerhorst, T.4    Kenemans, P.5    Walboomers, J.M.6
  • 2
    • 0033709552 scopus 로고    scopus 로고
    • Human papillomavirus infections in women with HIV disease: Prevalence, risk, and management
    • Jay N, Moscicki AB: Human papillomavirus infections in women with HIV disease: prevalence, risk, and management. AIDS Read 2000; 10: 659-668.
    • (2000) AIDS Read , vol.10 , pp. 659-668
    • Jay, N.1    Moscicki, A.B.2
  • 3
    • 0032940888 scopus 로고    scopus 로고
    • Human papillomavirus vaccines for cervical cancer
    • Murakami M, Gurski KJ, Steller MA: Human papillomavirus vaccines for cervical cancer. J Immunother 1999; 22: 212-218.
    • (1999) J Immunother , vol.22 , pp. 212-218
    • Murakami, M.1    Gurski, K.J.2    Steller, M.A.3
  • 4
    • 0032510076 scopus 로고    scopus 로고
    • Natural history of cervicovaginal papillomavirus infection in young women
    • Ho GY, Bierman R, Beardsley L, Chang CJ, Burk RD: Natural history of cervicovaginal papillomavirus infection in young women. N Engl J Med 1998; 338: 423-428.
    • (1998) N Engl J Med , vol.338 , pp. 423-428
    • Ho, G.Y.1    Bierman, R.2    Beardsley, L.3    Chang, C.J.4    Burk, R.D.5
  • 6
    • 1342300675 scopus 로고    scopus 로고
    • Physical state and expression of HPV DNA in benign and dysplastic cervical tissue: Different levels of viral integration are correlated with lesion grade
    • Hudelist G, Manavi M, Pischinger KI, Watkins-Riedel T, Singer CF, Kubista E, Czerwenka KF: Physical state and expression of HPV DNA in benign and dysplastic cervical tissue: different levels of viral integration are correlated with lesion grade. Gynecol Oncol 2004; 92: 873-880.
    • (2004) Gynecol Oncol , vol.92 , pp. 873-880
    • Hudelist, G.1    Manavi, M.2    Pischinger, K.I.3    Watkins-Riedel, T.4    Singer, C.F.5    Kubista, E.6    Czerwenka, K.F.7
  • 7
    • 28844508294 scopus 로고    scopus 로고
    • Clinical utility of HPV-DNA detection: Triage of minor cervical lesions, follow-up of women treated for high-grade CIN: An update of pooled evidence
    • Arbyn M, Paraskevaidis E, Martin-Hirsch P, Prendiville W, Dillner J: Clinical utility of HPV-DNA detection: triage of minor cervical lesions, follow-up of women treated for high-grade CIN: an update of pooled evidence. Gynecol Oncol 2005; 99(suppl):S7-S11.
    • (2005) Gynecol Oncol , vol.99 , Issue.SUPPL.
    • Arbyn, M.1    Paraskevaidis, E.2    Martin-Hirsch, P.3    Prendiville, W.4    Dillner, J.5
  • 8
    • 0032781685 scopus 로고    scopus 로고
    • Decreased programmed cell death in the uterine cervix associated with high risk human papillomavirus infection
    • Nair P, Nair MK, Jayaprakash PG, Pillai MR: Decreased programmed cell death in the uterine cervix associated with high risk human papillomavirus infection. Pathol Oncol Res 1999; 5: 95-103.
    • (1999) Pathol Oncol Res , vol.5 , pp. 95-103
    • Nair, P.1    Nair, M.K.2    Jayaprakash, P.G.3    Pillai, M.R.4
  • 9
  • 10
    • 0141645604 scopus 로고    scopus 로고
    • Co-overexpression of p53 and Bcl-2 proteins in HPV-induced squamous cell carcinoma of the uterine cervix
    • Grace VM, Shalini JV, Iekha TT, Devaraj SN, Devaraj H: Co-overexpression of p53 and Bcl-2 proteins in HPV-induced squamous cell carcinoma of the uterine cervix. Gynecol Oncol 2003; 91: 51-58.
    • (2003) Gynecol Oncol , vol.91 , pp. 51-58
    • Grace, V.M.1    Shalini, J.V.2    Iekha, T.T.3    Devaraj, S.N.4    Devaraj, H.5
  • 11
    • 0025876591 scopus 로고
    • The p53 tumour suppressor gene
    • Levine AJ, Momand J, Finlay CA: The p53 tumour suppressor gene. Nature 1991; 351: 453-456.
    • (1991) Nature , vol.351 , pp. 453-456
    • Levine, A.J.1    Momand, J.2    Finlay, C.A.3
  • 12
    • 0027034519 scopus 로고
    • The Bcl-2 oncogene and apoptosis
    • Hockenbery DM: The Bcl-2 oncogene and apoptosis. Semin Immunol 1992; 4: 413-420.
    • (1992) Semin Immunol , vol.4 , pp. 413-420
    • Hockenbery, D.M.1
  • 13
    • 0030938772 scopus 로고    scopus 로고
    • Apoptosis and cancer mechanisms
    • Pan H, Yin C, Van Dyke T: Apoptosis and cancer mechanisms. Cancer Surveys 1997; 29: 305-327.
    • (1997) Cancer Surveys , vol.29 , pp. 305-327
    • Pan, H.1    Yin, C.2    Van Dyke, T.3
  • 14
    • 0028352434 scopus 로고
    • The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
    • Waga S, Hannon GJ, Beach D, Stillman B: The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature 1994; 369: 574-578.
    • (1994) Nature , vol.369 , pp. 574-578
    • Waga, S.1    Hannon, G.J.2    Beach, D.3    Stillman, B.4
  • 15
    • 0030744827 scopus 로고    scopus 로고
    • Role of p53 tumor suppressor gene and Fas/Apo-1 in induction of apoptosis and differentiation of cancer cells
    • Takahashi R: Role of p53 tumor suppressor gene and Fas/Apo-1 in induction of apoptosis and differentiation of cancer cells. Leukemia 1997; 11: 331-333.
    • (1997) Leukemia , vol.11 , pp. 331-333
    • Takahashi, R.1
  • 17
    • 0028862440 scopus 로고
    • Expression and prognostic significance of Bcl-2 in ovarian tumours
    • Henriksen R, Wilander E, Oberg K: Expression and prognostic significance of Bcl-2 in ovarian tumours. Br J Cancer 1995; 72: 1324-1329.
    • (1995) Br J Cancer , vol.72 , pp. 1324-1329
    • Henriksen, R.1    Wilander, E.2    Oberg, K.3
  • 18
    • 0030007232 scopus 로고    scopus 로고
    • Immunohistochemical detection of p53, Bcl-2 and retinoblastoma proteins in follicular lymphoma
    • Nguyen PL, Zukerberg LR, Benedict WF, Harris NL: Immunohistochemical detection of p53, Bcl-2 and retinoblastoma proteins in follicular lymphoma. Am J Clin Pathol 1996; 105: 538-543.
    • (1996) Am J Clin Pathol , vol.105 , pp. 538-543
    • Nguyen, P.L.1    Zukerberg, L.R.2    Benedict, W.F.3    Harris, N.L.4
  • 21
    • 0034897124 scopus 로고    scopus 로고
    • Cell cycle aberrations in the pathogenesis of squamous cell carcinoma of the uterine cervix
    • Clarke B, Chetty R: Cell cycle aberrations in the pathogenesis of squamous cell carcinoma of the uterine cervix. Gynecol Oncol 2001; 82: 238-246.
    • (2001) Gynecol Oncol , vol.82 , pp. 238-246
    • Clarke, B.1    Chetty, R.2
  • 23
    • 0029899181 scopus 로고    scopus 로고
    • Molecular thanatopsis: A discourse on the Bcl-2 family and cell death
    • Yang E, Korsmeyer SJ: Molecular thanatopsis: a discourse on the Bcl-2 family and cell death. Blood 1996; 88: 386-401.
    • (1996) Blood , vol.88 , pp. 386-401
    • Yang, E.1    Korsmeyer, S.J.2
  • 24
    • 0025173902 scopus 로고
    • The use of general primers in the polymerase chain reaction permits the detection of a broad spectrum of human papillomavirus genotypes
    • Snijders PJ, Van den Brule AJ, Schrijnemakers HF, Snow G, Meijer CJ, Walboomers JM: The use of general primers in the polymerase chain reaction permits the detection of a broad spectrum of human papillomavirus genotypes. J Gen Virol 1990; 71: 173-181.
    • (1990) J Gen Virol , vol.71 , pp. 173-181
    • Snijders, P.J.1    Van Den Brule, A.J.2    Schrijnemakers, H.F.3    Snow, G.4    Meijer, C.J.5    Walboomers, J.M.6
  • 25
    • 0026696242 scopus 로고
    • General primer polymerase chain reaction in combination with sequence analysis for identification of potentially novel human papillomavirus genotypes in cervical lesions
    • Van den Brule AJ, Snijders PJ, Raaphorst PM, Schrijnemakers HF, Delius H, Gissmann L, Meijer CJ, Walboomers JM: General primer polymerase chain reaction in combination with sequence analysis for identification of potentially novel human papillomavirus genotypes in cervical lesions. J Clin Microbiol 1992; 30: 1716-1721.
    • (1992) J Clin Microbiol , vol.30 , pp. 1716-1721
    • Van Den Brule, A.J.1    Snijders, P.J.2    Raaphorst, P.M.3    Schrijnemakers, H.F.4    Delius, H.5    Gissmann, L.6    Meijer, C.J.7    Walboomers, J.M.8
  • 26
    • 0002523110 scopus 로고
    • PCR detection of genital human papillomavirus
    • Persing D, Smith TF, Tenover FC, White TJ (eds): Washington, ASM Press
    • Bauer HM, Manos MM: PCR detection of genital human papillomavirus; in Persing D, Smith TF, Tenover FC, White TJ (eds): Diagnostic Molecular Microbiology. Washington, ASM Press, 1993, pp 407-413.
    • (1993) Diagnostic Molecular Microbiology , pp. 407-413
    • Bauer, H.M.1    Manos, M.M.2
  • 27
    • 23244438005 scopus 로고    scopus 로고
    • Elevated 10-year risk of cervical precancer and cancer in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of type-specific HPV testing in clinical practice
    • Khan MJ, Castle PE, Lorincz AT, Wacholder S, Sherman M, Scott DR, Rush BB, Glass AG, Schiffman M: Elevated 10-year risk of cervical precancer and cancer in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of type-specific HPV testing in clinical practice. J Natl Cancer Inst 2005; 97: 1072-1079.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1072-1079
    • Khan, M.J.1    Castle, P.E.2    Lorincz, A.T.3    Wacholder, S.4    Sherman, M.5    Scott, D.R.6    Rush, B.B.7    Glass, A.G.8    Schiffman, M.9
  • 28
    • 33747167086 scopus 로고    scopus 로고
    • Immunohistochemical and functional biomarkers of value in female genital tract lesions
    • McCluggage WG: Immunohistochemical and functional biomarkers of value in female genital tract lesions. Int J Gynecol Pathol 2006; 25: 101-120.
    • (2006) Int J Gynecol Pathol , vol.25 , pp. 101-120
    • McCluggage, W.G.1
  • 29
    • 34248594717 scopus 로고    scopus 로고
    • Prognosis of adenocarcinoma of the uterine cervix: P53 expression correlates with higher incidence of mortality
    • Baalbergen A, Ewing-Graham PC, Eijkemans MJ, Helmerhors TJM: Prognosis of adenocarcinoma of the uterine cervix: p53 expression correlates with higher incidence of mortality. Int J Cancer 2007; 121: 106-110.
    • (2007) Int J Cancer , vol.121 , pp. 106-110
    • Baalbergen, A.1    Ewing-Graham, P.C.2    Eijkemans, M.J.3    Helmerhors, T.J.M.4
  • 30
    • 0027164121 scopus 로고
    • P53 CM-1 expression is not associated with prognosis in uterine cervical carcinoma
    • Oka K, Nakano T, Arai T: p53 CM-1 expression is not associated with prognosis in uterine cervical carcinoma. Cancer 1993; 72: 160-164.
    • (1993) Cancer , vol.72 , pp. 160-164
    • Oka, K.1    Nakano, T.2    Arai, T.3
  • 31
    • 0027098180 scopus 로고
    • Frequent occurrence of p53 gene mutations in uterine cancers at advanced clinical stage and with aggressive histological phenotypes
    • Tsuda H, Hirohashi S: Frequent occurrence of p53 gene mutations in uterine cancers at advanced clinical stage and with aggressive histological phenotypes. Jpn J Cancer Res 1992; 83: 1184-1191.
    • (1992) Jpn J Cancer Res , vol.83 , pp. 1184-1191
    • Tsuda, H.1    Hirohashi, S.2
  • 33
    • 73749083580 scopus 로고    scopus 로고
    • Association of p16, p53, Ki-67 expressions with high-risk human papilloma virus infection in cervical intraepithelial neoplasia (in Chinese)
    • Shi J, Zheng JS, Yin F, Hu WW, Huang XJ, Zhou XL: Association of p16, p53, Ki-67 expressions with high-risk human papilloma virus infection in cervical intraepithelial neoplasia (in Chinese). Nan Fang Yi Ke Da Xue Xue Bao 2007; 27: 515-517.
    • (2007) Nan Fang Yi Ke da Xue Xue Bao , vol.27 , pp. 515-517
    • Shi, J.1    Zheng, J.S.2    Yin, F.3    Hu, W.W.4    Huang, X.J.5    Zhou, X.L.6
  • 35
    • 22944486725 scopus 로고    scopus 로고
    • An immunohistochemical comparison between low-grade and high-grade ovarian serous carcinomas: Significantly higher expression of p53, MIB1, BCL2, HER-2/neu, and C-KIT in high-grade neoplasms
    • O'Neill CJ, Deavers MT, Malpica A, Foster H, McCluggage WG: An immunohistochemical comparison between low-grade and high-grade ovarian serous carcinomas: significantly higher expression of p53, MIB1, BCL2, HER-2/neu, and C-KIT in high-grade neoplasms. Am J Surg Pathol 2005; 29: 1034-1041.
    • (2005) Am J Surg Pathol , vol.29 , pp. 1034-1041
    • O'Neill, C.J.1    Deavers, M.T.2    Malpica, A.3    Foster, H.4    McCluggage, W.G.5
  • 37
    • 0033552585 scopus 로고    scopus 로고
    • The role of the E6-p53 interaction in the molecular pathogenesis of HPV
    • Thomas M, Pim D, Banks L: The role of the E6-p53 interaction in the molecular pathogenesis of HPV. Oncogene 1999; 15: 7690-7700.
    • (1999) Oncogene , vol.15 , pp. 7690-7700
    • Thomas, M.1    Pim, D.2    Banks, L.3
  • 38
    • 0028347587 scopus 로고
    • Modulation of transcriptional regulatory properties of p53 by HPV E6
    • Crook T, Fisher C, Masterson PJ, Vousden KH: Modulation of transcriptional regulatory properties of p53 by HPV E6. Oncogene 1994; 9: 1225-1230.
    • (1994) Oncogene , vol.9 , pp. 1225-1230
    • Crook, T.1    Fisher, C.2    Masterson, P.J.3    Vousden, K.H.4
  • 40
    • 0033158714 scopus 로고    scopus 로고
    • Analysis of Bcl-2, Bax and Survivin genes in uterine cancer
    • Saitoh Y, Yaginuma Y, Ishikawa M: Analysis of Bcl-2, Bax and Survivin genes in uterine cancer. Int J Oncol 1999; 15: 137-141.
    • (1999) Int J Oncol , vol.15 , pp. 137-141
    • Saitoh, Y.1    Yaginuma, Y.2    Ishikawa, M.3
  • 44
    • 0028879906 scopus 로고
    • The possible role of Bcl-2 expression in the progression of tumors of the uterine cervix
    • Saegusa M, Takano Y, Hashimura M, Shoji Y, Okayasu I: The possible role of Bcl-2 expression in the progression of tumors of the uterine cervix. Cancer 1995; 76: 2297-2303.
    • (1995) Cancer , vol.76 , pp. 2297-2303
    • Saegusa, M.1    Takano, Y.2    Hashimura, M.3    Shoji, Y.4    Okayasu, I.5
  • 45
    • 0028149786 scopus 로고
    • Checkpoints of dueling dimers foil death wishes
    • Oltvai ZN, Korsmeyer SJ: Checkpoints of dueling dimers foil death wishes. Cell 1994; 79: 189-192.
    • (1994) Cell , vol.79 , pp. 189-192
    • Oltvai, Z.N.1    Korsmeyer, S.J.2
  • 46
    • 0029996069 scopus 로고    scopus 로고
    • Clinical implications of the p53 gene
    • Sidransky D, Hollstein M: Clinical implications of the p53 gene. Annu Rev Med 1996; 47: 285-301.
    • (1996) Annu Rev Med , vol.47 , pp. 285-301
    • Sidransky, D.1    Hollstein, M.2
  • 47
    • 4444261662 scopus 로고    scopus 로고
    • Prognostic significance of Bax, Bcl-2, and p53 expressions in cervical squamous cell carcinoma treated by radiotherapy
    • Wootipoom V, Lekhyananda N, Phungrassami T, Boonyaphiphat P, Thongsuksai P: Prognostic significance of Bax, Bcl-2, and p53 expressions in cervical squamous cell carcinoma treated by radiotherapy. Gynecol Oncol 2004; 94: 636-642.
    • (2004) Gynecol Oncol , vol.94 , pp. 636-642
    • Wootipoom, V.1    Lekhyananda, N.2    Phungrassami, T.3    Boonyaphiphat, P.4    Thongsuksai, P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.